01. Louder Than Words
02. Torture
03. What You Need
04. Here Comes The Reign
05. World On Fire
06. Save Your Life
07. Sunday
08. String Theory
09. Come Back To Me
Instrumental Bonus Tracks Version (Download Only)
10. Louder Than Words (Intrumental)
11. Torture (Intrumental)
12. What You Need (Intrumental)
13. Here Comes The Reign (Intrumental)
14. World On Fire (Intrumental)
15. Save Your Life (Intrumental)
16. Sunday (Intrumental)
17. String Theory (Intrumental)
18. Come Back To Me (Intrumental)
Les Friction is Helmut Vonlitchen & Nihl Finch
Vocals: Paint
The year is 2048 AD. Humans are now able to leave their earthly home and travel to other dimensions. While traveling, a shell of their body remains on earth and functions at a reduced capacity.
However, with the sweetness of life often there follows the bitterness of mortality..... my brother, Franz, passed away in May. It was entirely unexpected. / As for me, I will begin to rebuild what was washed away, albeit in a form other than ES Posthumus. / Franz was an extraordinary talent...Most of all, however, I will miss his wit and humor... -Helmut Vonlichten.
Les Frictionのサウンド・ディレクションは事実、es.Posthumusを踏襲したものでありながら、『Furious』と評されるほどに、かつてないほど激情的で、叩き付けるような刺々しい響きに彩られる。新メンバーであるNihl Finchの指導のもと、神々しく、時に扇情的なPaintの歌声は、それ自体でフィルム・スコアとして流用可能なオペラチックな楽曲に、どこか時代回帰的な作用をもたらしている。
Les Frictionも全く斬新な方向性を築いているとは言えず、むしろ"Makara"の頃から顕著であった、Hans ZimmerやCraig Armstrongなどに代表されるハリウッド・スコア風の楽曲への接近が、ここに来て確信に至ったと言えるほどに、ESPとしての独創性を欠いていると評することも出来るかもしれない。
"Louder Than Words"は、アルバムのリード・トラックとして総ての要素が注ぎ込まれた会心作ではあるが、それでも豊穣な音楽世界を代弁するには及ばない。ここに刻まれた9つの楽曲の辿るドラマの連続性こそが、ストーリーテラーであるLes Frictionの輪郭をなぞる唯一の道程なのだ。
数少ないポップ・トラックである"What You Need"や"Sunday" ("Louder…"のメロディが一部引用）においても、Posthumus時代からのトレードマークである特徴的なクレッシェンドが登場する。（ただ、この技法自体は、1990年代中期のTrailer Musicプロダクションにおいて既に確立されていたものだと、私は記憶している。）
また今作では、とりわけ"World on Fire"などに顕著な様に、映画本編にも使用されていそうな最先端のサウンド・エフェクト、プログラミングが施されている部位が多く聴き取れ、このプロジェクトが、ESPの"進化形"であると銘打ったコンセプトを一際印象づけている。
(※ダウンロード盤限定の"Instrumental"は若干楽曲構成やミキシングが異なる。）
そして物語は、私が慟哭を禁じ得なかった"Come Back to Me"へと至る。
ピタゴラス哲学の教示『音楽は相反するあらゆるものの共鳴』は、es.Posthumusの挙げた作曲コンセプトの一つであった。そしてES,Posthumus = "Experimental Sounds, all things Past"という名に倣う如く、Vonlichten兄弟の物語は一つ幕を閉じ、そして今また、見えざる彼岸に向かい合って創作を交わしているのだ。
If I sing with Angels,
Will you hear me?
If I sing with Angels,
Will you cross the line?
I hear your voice but you're not here.
I walk the halls and I'm alone.
You're not coming home.
I'm holding out 'til we're out of time.
Would you pierce the veil?
Would you cross the line?
I can feel you here, souls redefined.
I can't let go of our design.
Would you pierce the veil?
Would you cross the line?
(Cumulative rainfall anomalies and vegetation index anomalies for East Africa, Sudan and Southern Africa.)
□ GinnyBarbour:
#PLoS NTDs: Climate Teleconnections and Recent Patterns of Human and Animal Disease Outbreaks dx.plos.org/10.1371/journa…
東・南アフリカ及びスーダンの気候変動と疾病発生の時空間パターン相関。
Extremes in climate conditions forced by the El Niño/Southern Oscillation (ENSO) lead to severe droughts or floods, ideal ecological conditions for disease vectors to emerge, and may result in epizootics and epidemics of Rift Valley fever and chikungunya.
However, the immune status of livestock (Rift Valley fever) and human (chikungunya) populations is a factor that is largely unknown but very likely plays a role in the spatial-temporal patterns of these disease outbreaks. As the frequency and severity of extremes in climate increase, the potential for globalization of vectors and disease is likely to accelerate. Understanding the underlying patterns of global and regional climate variability and their impacts on ecological drivers of vector-borne diseases is critical in long-range planning of appropriate disease and disease-vector response, control, and mitigation strategies.
□ FX: an RNA-Seq analysis tool on the cloud. >> http://fx.gmi.ac.kr/
クラウド上で並列実行可能なRNA-Seqツール。ローカルHadoopクラスタ上でインストール可能
GMI-SNU FX: X is a user-Frendly RNA-Seq gene eXpression analysis tool, empowered by the concept of cloud-computing. With FX, you can simply upload your RNA-Seq raw FASTQ data on the cloud, and let the computing infra to do the heavy analysis.
The BioWeatherMap initiative is a global, grassroots, distributed environmental sensing effort aimed at answering some very basic questions about the geographic and temporal distribution patterns of microbial life.
□ Improved prediction of RNA tertiary structure with insights into native state dynamics
We propose RSIM, an improved RNA fragment assembly method that preserves RNA global secondary structure while sampling conformations. This approach enhances the quality of predicted RNA tertiary structure, provides insights into the native state dynamics, and generates a powerful visualization of the RNA conformational space. RSIM is available for download from http://www.github.com/jpbida/rsim.
□ 直接シミュレーション・モンテカルロ法に分子間ポテンシャルを実装するという提案。あらゆる球面体モデルに適用可能。 Direct simulation Monte Carlo method for an arbitrary intermolecular potential http://ow.ly/8FQ4p
□ A Semantic Problem Solving Environment for Integrative Parasite Research: Identification of Intervention Targets for Trypanosoma cruzi
The SPSE uses biomedical ontologies as the core knowledge resource and data model along with related Semantic Web technologies. Early in this project we realized the importance of provenance to scientists' data analysis needs. Hence, domain-specific (i.e., semantic) provenance [13] has been tightly integrated within the SPSE. The SPSE provides an environment for researchers to query the data as well as the associated provenance information, all stored in a RDF triples, with or without external databases, using a visual query tool.
The server includes four sets of tools: 'Slicer detector' for detecting sRNAs targeting input genes, 'dRNA mapper' for detecting degradome (d)RNA products derived from input genes, 'preMIR detector' for identifying miRNA precursor (MIR) or tasiRNA precursor (TAS) of input sRNAs, and 'sRNA mapper' for mapping sRNAs onto input genes.
□ SOAP3: Ultra-fast GPU-based parallel alignment tool for short reads
SOAP3 is the first short read alignment tool that leverages the multi-processors in a graphic processing unit (GPU) to achieve a drastic improvement in speed. We adapted the compressed full-text index (BWT) used by SOAP2 in view of the advantages and disadvantages of GPU.
□ emblebies:
Web Services (via REST/SOAP) for several EMBOSS sequence translation tools are now available at the EBI: bit.ly/coZ99k
□ sebhtml:
I finished porting the Ray genome assembler to the plugin architecture of RayPlatform. github.com/sebhtml/ray/tr… #Ray #RayPlatform #illumina
□ Understanding Big Data: Analytics for Enterprise Class Hadoop and Streaming Data
FedX is a practical framework for transparent access to Linked Data sources through a federation. It incorporates new sophisticated optimization techniques combined with effective variants of existing techniques and is thus a highly scalable solution for practical federated query processing.
These recent developments show that the importance of the public database resources, which is obvious to any biologist, needs to be constantly highlighted to the national and international financing bodies.
In Europe, coordination of the bioinformatics infrastructure is planned through the EU-sponsored ELIXIR (European Life Sciences Infrastructure for Biological Information, http://www.elixir-europe.org) project, which aims at guaranteeing seamless access to biological information by integrating data generators and data centers throughout Europe.
□ Sagebio:
Developing predictive molecular maps of human disease through community-based modeling bit.ly/whMR8T #openscience #bigdata
Sage Bionetworks Commons project, including the efforts made to date in building a computational platform and a data and model repository that includes the associated analysis tools, as well as the development of data sharing rules and policies. We explain how this environment will drive us toward the generation of better maps of disease and become a forum for reproducible and reusable data and analyses.
Community involvement will be necessary to address the many concerns that such a complex endeavor will encounter, including ways to incentivize data sharing, to promote the appropriate attribution for the data generators and map builders and to address policy issues associated with the protection of human data. Engagement of stakeholders across different constituencies to drive the development of the policies and resources necessary for the project is crucial
To make full use of research data, the bioscience community needs to adopt technologies and reward mechanisms that support interoperability and promote the growth of an open 'data commoning' culture. Here we describe the prerequisites for data commoning and present an established and growing ecosystem of solutions using the shared 'Investigation-Study-Assay' framework to support that vision.
The ISA Commons is a growing community that uses the ISA metadata tracking framework to facilitate standards-compliant collection, curation, management and reuse of datasets in an increasingly diverse set of life science domains.
High-content screening for RNAi can provide a rich source of high-dimensional phenotypic data to explore the effects of knockdown in a variety of ways that move beyond simple threshold-based selection methods.
“We developed a series of tiered models in order to refine groups into finer populations, allowing us to apply gene ontology (GO) enrichment analysis methods to provide functional annotations and hence prioritize genes for follow-up analysis.”
□ SAGRudd:
Molecular Diagnosis of Infantile Mitochondrial Disease with Targeted Next-Generation Sequencing = #awesome j.mp/y5WE1P
We performed “MitoExome” sequencing of the mitochondrial DNA (mtDNA) and exons of ~1000 nuclear genes encoding mitochondrial proteins and prioritized rare mutations predicted to disrupt function. Because patients and healthy control individuals harbored a comparable number of such heterozygous alleles, we could not prioritize dominant-acting genes… The results underscore the potential and challenges of deploying NGS in clinical settings.
sequencing technology is evolving at a much faster pace. At present, the per-base cost of sequencing is dropping by about half every five months, and this trend shows no sign of slowing down. Also, by some estimates, there are 1,700 high-throughput sequencers in operation across the globe, sequencing more than a million human genomes ? upwards of 13 petabases ? per year. Factor in all of these variables, and the logarithmic graphs start looking like signs of a data-management doomsday.
As I was exploring open data sources, I came across USA spending. This site contains information on US government contract awards and other disbursements, such as grants and loans.
First, we note that 15.7 billion dollars in federal contracts were obligated to vendors in the state of Maryland in the fiscal year 2011. Next, we note that about 11.5% of the total federal money allocated in contracts went to Lockheed Martin! In fact, the top 10 companies in terms of dollar value of contracts received were given 41% of all the contracted dollars, which amounts to about 6.5 billion dollars. The top 100 contractors received 72% of all contracted dollars.
□ boolean3 (beta) an R package for modeling causal complexity
Additional theoretical content can be found at the Boolean Statistics homepage. Braumoeller and Carson have a 2011 paper titled “Political Irrelevance, Democracy, and the Limits of Militarized Conflict” in the Journal of Conflict Resolution that provides a useful example of the approach.
Labcyte Inc., the developer of acoustic liquid handling, and QIAGEN, the leading global provider of sample and assay technologies, announced today that QIAGEN FlexiPlate siRNA reagent libraries are now available in Labcyte Echo® qualified microplates. These microplates enable researchers to use the Echo® liquid handler to miniaturize the transfer of small interfering RNA reagents.
□ plantbiology:
Current Biology 'Rapid Establishment of Genetic Incompatibility through Natural Epigenetic Variation' ow.ly/8Idhn
The Hackerspace Global Grid was borne out of a call to action at the Chaos Communication Congress in Berlin, where hackers of all stripes gather to mull the issues of the day as they relate to their craft. Hacker activist Nick Farr?motivated by legislation like the Stop Online Piracy Act (SOPA) in the U.S.?called on the community to contribute to a project that would remove the power of censorship from governments and corporations by creating an uncensored Internet in the free frontier of space.
One of the nice things about working in a world-class ecology group is the statistical rigor with which ecologists analyse their results. Unfortunately, this rigor is often missing in computational intelligence…
リードトラック"Face to Face"における生音のコラージュや、"Fieldwork"のストリングス・ループ、"Swoon"で聴かれるIDM系のドープなチルアウトも、Wilsonが所謂"DJ Track Maker"ではなく、一個のコンポーザーとしての姿勢で、その独自の低音法にマークを印証している。
RISP is Richard Devine’s most advanced exploration of experimental acoustic space to date, now available from Detroit Underground. These compositions were created and initially sequenced on the Euro rack modular and Elektron Octatrack machines.
Advanced media technology driven by algorithm-based generative time structures forge new pathways to critical discourse across six tracks. Expect new forms of becoming especially reflection, restfulness and peaceful integration subsequent to witnessing crazy, chaotic, seemingly broken machines talking to one another, somehow harmonized via Richard Devine’s remarkable human/alien sound design.
These recent developments show that the importance of the public database resources, which is obvious to any biologist, needs to be constantly highlighted to the national and international financing bodies.
In Europe, coordination of the bioinformatics infrastructure is planned through the EU-sponsored ELIXIR (European Life Sciences Infrastructure for Biological Information, http://www.elixir-europe.org) project, which aims at guaranteeing seamless access to biological information by integrating data generators and data centers throughout Europe.
Our analysis is readily applicable to various types of noise control and to different types of system; for example, we can orthogonally control the mean and noise levels and can control system dynamics such as noisy oscillations. As an illustration we applied our method to HIV and yeast gene expression systems and metabolic networks. The oscillatory signal control was applied to p53 oscillations from DNA damage.
Furthermore, we showed that the efficiency of orthogonal control can be enhanced by applying extrinsic noise and feedback. Our noise control analysis can be applied to any stochastic model belonging to continuous time Markovian systems such as biological and chemical reaction systems, and even computer and social networks. We anticipate the proposed analysis to be a useful tool for designing and controlling synthetic gene networks.
This independence was shown to be rooted to a certain network structure satisfying Feinberg's deficiency zero theorem [24]?[26]. We will show that when such species independence occurs, the orthogonal control of mean and noise levels is not possible, but that the application of extrinsic noise or feedback could help achieve orthogonal control.
Amazon Web Services (AWS) has launched a fully managed NoSQL database service in the cloud called DynamoDB that aims to provide seamless scalability on the fly. AWS is claiming that their new service will offload administrative tasks such as hardware provisioning, setup, configuration, replication, software patching, and cluster scaling.
APART, a novel automated computational pipeline, providing a complete workflow for the reliable detection of RNA processing products from next-generation-sequencing data. The major features include efficient handling of non-unique reads, detection of novel stable ncRNA transcripts and processing products and annotation of known transcripts based on multiple sources of information.
To disclose the potential of APART, we have analyzed a cDNA library derived from small ribosome-associated RNAs in Saccharomyces cerevisiae. By employing the APART pipeline, we were able to detect and confirm by independent experimental methods multiple novel stable RNA molecules differentially processed from well known ncRNAs, like rRNAs, tRNAs or snoRNAs, in a stress-dependent manner.
Ultra-deep RNA sequencing has become a powerful approach for genome-wide analysis of pre-mRNA alternative splicing. We develop MATS (multivariate analysis of transcript splicing), a Bayesian statistical framework for flexible hypothesis testing of differential alternative splicing patterns on RNA-Seq data.
MATS uses a multivariate uniform prior to model the between-sample correlation in exon splicing patterns, and a Markov chain Monte Carlo (MCMC) method coupled with a simulation-based adaptive sampling procedure to calculate the P-value and false discovery rate (FDR) of differential alternative splicing. Importantly, the MATS approach is applicable to almost any type of null hypotheses of interest, providing the flexibility to identify differential alternative splicing events that match a given user-defined pattern.
The solutions streamline data acquisition and automate data review and are expected to accelerate the use of mass spec technologies by simplifying the workflows. The partnership is also expected to ensure better results in clinical research, forensic toxicology, and pre-clinical and clinical trials of new drugs
□ rnomics:
Fine-Scale Temporal Dynamics of a Fragmented Lotic Microbial Ecosystem: Microbial ecosystemsbit.ly/ADIwzS
Scaling is an important concept in landscape ecology, where it is usually used in a geographical, rather than temporal perspective34. A lesson from experiment described in this study is that a bacterial community can change drastically and rapidly and yet have an equally rapid recovery. Our data emphasize the need for a re-evaluation of the time scale of microbial sampling experiments beyond diurnal cycles, especially in dynamic environments such as fresh water streams, lakes and irrigated soil.
□ rnomics:
Increased sensitivity of next generation sequencing-based expression profiling after globin reduction in... bit.ly/zM2ZMU #BMC
We have removed globin transcripts from 6 human whole blood RNA samples with a human globin reduction kit and compared them with the same non-reduced samples using deep Serial Analysis of Gene Expression.The reduction of globin transcripts in whole blood samples constitutes a reproducible and reliable method that can enrich data obtained from next generation sequencing-based expression profiling.
Here, we review the technological developments and experimental designs that have enabled differential network mapping at very large scales and highlight biological insight that has been derived from this type of analysis. We argue that differential network mapping, which allows for the interrogation of previously unexplored interaction spaces, will become a standard mode of network analysis in the future, just as differential gene expression and protein phosphorylation studies are already pervasive in genomic and proteomic analysis.
□ Merck4Bio:
Single-celled #organism can evolve multicellularity within months bit.ly/zTl26q
The origin of multicellular life, one of the most important developments in Earth’s history, could have occurred with surprising speed, US researchers have shown. In the lab, a single-celled yeast (Saccharomyces cerevisiae) took less than 60 days to evolve into many-celled clusters that behaved as individuals. The clusters even developed a primitive division of labour, with some cells dying so that others could grow and reproduce.
TriLink BioTechnologies today said that Sigma-Aldrich will sell and distribute the firm's CleanAmp dNTPs globally.
The San Diego-based firm said that its CleanAmp dNTPs, which are designed for hot-start PCR, are an "ideal complement to Sigma-Aldrich's product and service offerings." It added that the latest advancement in CleanAMP dNTP chemistry provides "improved amplicon yield in endpoint PCR and earlier Cq values in fast cycling real-time PCR."
Financial and other terms of the agreement were not disclosed.
□ genetics_blog:
Interesting results in genomeweb survey: exome arrays > GWAS; RNA-seq, people plan to spend more $ on #bioinformatics genomeweb.com/forward/emailr… Survey Finds Exome Arrays on the Upswing as GWAS, Gene Expression Apps Decline
□ OxfordJNLsJapan:
【科学・社会】学界におけるリサーチツールの共有：日本でのケーススタディ oxford.ly/wrr8VH Sharing research tools in academia: the case of Japan
Although studies in the US have indicated that the trend of academic capitalism or commercialization deters material transfer, our results show limited negative impact in this regard. Second, this study examines the use of central repositories of research tools as a means to the wider dissemination of such tools. The results suggest that entrepreneurial scientists and scientists in public research organizations are more willing to provide their research tools through this publicly accessible system.
As genome sequence data sets continue to grow, there is a pressing need to develop accurate yet memory-efficient means of assembling genomesde novo. Using new computational tools, the authors assembled a human genome using less than 64 gigabytes of memory.
□ SAGRudd:
BamView: visualizing and interpretation of next-generation sequencing read alignments = #awesome j.mp/zB6kKT
BamView allows the user to study NGS data in the context of the sequence and annotation of the reference genome. Single nucleotide polymorphism (SNP) density and candidate SNP sites can be highlighted and investigated, and read-pair information can be used to discover large structural insertions and deletions. The application will also calculate simple analyses of the read mapping, including reporting the read counts and reads per kilobase per million mapped reads (RPKM) for genes selected by the user.
□ NatureRevGenet:
Review (in GWAS Series). G. Gibson on 20 arguments for and vs two main models for the genetic basis of complex traits: bit.ly/wKWAOd
Genome-wide association studies have greatly improved our understanding of the genetic basis of disease risk. The fact that they tend not to identify more than a fraction of the specific causal loci has led to divergence of opinion over whether most of the variance is hidden as numerous rare variants of large effect or as common variants of very small effect. Here I review 20 arguments for and against each of these models of the genetic basis of complex traits and conclude that both classes of effect can be readily reconciled.
international drug conventions protect public health, or otherwise, and concludes that national policies aligned with risks of different drugs are needed. The authors state: “The cultural positions of different drugs vary enough to preclude universal policies on how to deal with all illicit or indeed licit drugs. From the perspective of public health, we need to move towards a control system that is more aligned with the risks that different drugs pose to users and shows an understanding of the effects of different regulatory approaches on drug use and harm.”
The on-line version of the article included interactive features like this interactive map showing where your household ranks in the country and in local regions. The print edition, however, included some different (and necessarily static) representations of US wealth data, such as this map of where the wealthiest 1% live
□ CODEX: Exploration of semantic changes between ontology versions
The CODEX (Complex Ontology Diff Explorer) application allows for determining semantic (complex) changes between two versions of an ontology. The application is based on a general diff algorithm called COntoDiff (Complex Ontology Diff) which applies rules to iteratively compute the most compact (semantically richest) diff between two ontology versions.
□ PLoS:
Analysis of 500 scholarly article tweets 88% discuss it 9% are author/publisher originated 27% use conclusions bit.ly/AEsIwD #scio12
I could annotate each probeset ID with a gene symbol, gene name, Ensembl ID, and have that Ensembl ID hyperlink out to the Ensembl genome browser.
□ GeneticAlliance:
Calling all social science researchers! Improve your genetics literacy with a new online course from NCHPEG & NIH: ow.ly/8wKJb
The nature/nurture debate has confounded research on social and behavioral phenotypes since the late nineteenth century. This program takes the position that the debate is unhelpful and misleading, because no gene operates outside of an environment - beginning with the environment of the cell and extending to the influences of the external world.
We consider the sparse Fourier transform problem: given a complex vector x of length n, and a parameter k, estimate the k largest (in magnitude) coefficients of the Fourier transform of x. The problem is of key interest in several areas, including signal processing, audio/image/video compression, and learning theory.
We propose a new algorithm for this problem. The algorithm leverages techniques from digital signal pro- cessing, notably Gaussian and Dolph-Chebyshev filters. The resulting algorithm is structurally simpler than its predecessors. As a consequence, we are able to extend considerably the range of sparsity, k, for which the algorithm is faster than FFT, both in theory and practice.
□ Trends_Endo_Met:
“Article of the Future” video showing an improved, intuitive and interactive interfacethe Science Direct redesign! articleofthefuture.com
The Article of the Future project- an ongoing initiative aiming to revolutionize the traditional format of the academic paper in regard to three key elements: presentation, content and context.
□ FutureProofNSW:
Future Proof: System migrations to archives (a research paper from the digital archives team) bit.ly/xL0fzj #archives
This research paper discusses three problems with using the term transfer to describe the processes that precede ingest into the digital archives and recommends instead the adoption of a project-based, system migration approach.
□ 4pdf:
an introduction to systems biology design principles of biological circuits: bit.ly/xzpWR9
□ elsevierjp:
RT @Luke0629 これ面白そう。愛情と誠実に関する生物学的心理学研究の総論。"Love is more than just a kiss: A neurobiological perspective of love … bit.ly/xaowhm
□ thinkgeek:
Physics paper finds Death Star could destroy Earth, but not Jupiter: j.mp/w0R1xo Good to know. #science
デス・スターは地球を破壊出来るけど、木星は無理？惑星の重力結合エネルギーを上回るジュール量から試算。地球では2.25x10^32J、木星ではその千倍必要
□ DBCLS: LinkedData Study Meeting.
□ dbcls:
第3回LinkedData勉強会 の中継を開始します (Broadcasting live at ustre.am/fg0g)
1. About Us
2. Beyond Vision
3. Breathing Sunlight
4. Eternal Fantasy
5. Floating Clouds
6. I Hear Your Voice
7. Intro
8. Sad In Joy
9. The Nighttime
10. Where Do We Go From Here
11. Fallacy Of Faith
12. Whispered Lullaby
All music composed by:
Adriaan Baussens (Belgium)
Ioannis Sioutis (Greece)
Enigma系Electronicaデュオ、Twins in Mindのニューアルバム・リリースに先駆けたコンペティションが行われています。
Information technology has become a ubiquitous presence. By visualizing the processes that underlie our interactions with this technology we can trace what happens to the information we feed into the network.
□ Experimental demonstration of a universally valid error?disturbance uncertainty relation in spin measurements
A correct formulation of the error?disturbance uncertainty relation, taking recoil into account, is essential for a deeper understanding of the uncertainty principle, as Heisenberg’s original relation is valid only under specific circumstances. A new error?disturbance relation, derived using the theory of general quantum measurements, has been claimed to be universally valid.
Here, we report a neutron-optical experiment that records the error of a spin-component measurement as well as the disturbance caused on another spin-component. The results confirm that both error and disturbance obey the new relation but violate the old one in a wide range of an experimental parameter.
Ion Torrent will sell the tabletop machine, called the Ion Proton Sequencer, for $99,000 to $149,000, making it affordable for large medical practices or clinics; existing sequencers cost up to $750,000.
□ DailyNewsGW:
Illumina Introduces One-Day Genome Sequencer; New Business Groups: read more bit.ly/wnCoS5
The firm's announcement comes on the same day that competitor Life Technologies introduced its Ion Proton Sequencer, a new instrument designed to sequence an entire human genome in a day for $1,000.
Illumina didn't provide the reagents costs for sequencing a whole genome with the new system, called the HiSeq 2500.
□ portablegenomic:
Life Technologies Rises Most Since 2009 on New Gene-Sequencing Machine - Bloomberg bloom.bg/xN3tgq via @BloombergNews
□ Synbiota:
A great article! It's what's next! “@raymondmccauley: The @WSJ highlights real work by biohackers at @BioCuriousLab: lnkd.in/tn-pqE”
The research team will now thoroughly analyze the data gathered in this second round of data collection. In parallel, the team has started to implement a simulator for testing the identified local rules of interaction in such a Crowdsourcing/Open Innovation context and other findings, comparing them with empirical data from other disciplines (e.g., management science).
Darwin Core continues to be integrated into new research communities. For example, the Nordic Genetic Resource Center (NordGen; http://www.nordgen.org) and Bioversity International (formerly IPGRI) (http://www.bioversityinternational.org) have sought to take advantage of Darwin Core on behalf of the European plant genetic resources and genebank community and, at the same time, share rich discipline-specific genetic resource information.
□ Darwin2009:
Molecular Ecology Special Issue: Social systems: demographic and genetic issues ow.ly/8skby
Animal societies are built on the two pillars of direct and indirect fitness; the former arise through cooperation and reciprocity, and the latter stem from kin selection and biological altruism. The exact role and correct interpretation of kin selection and inclusive fitness have been much debated recently…
□ pvanbaarlen:
Very impressive: Genetic Co-Occurrence Network across 600 Microbes - functional coupling of genes to synthetic biology bit.ly/zujWiO
□ emblebi:
New computational technique reveals hidden genetic variants - Nature Genetics article w/ colleagues at TGAC and WTCHG: bit.ly/wtF1ID
Cortex makes it possible to compare many genomes using colour-coded de Bruijn graphs, and has already revealed new biological insights. For example, it was used in a joint assembly of over 150 genomes from the 1000 Genomes Project to show that each person has around 1.4 million DNA bases that differ from the “reference genome”; a significant amount of this divergence has a biological function.
Our approach is to apply cutting-edge genomic technologies to observe the flux of genetic variation -- the Earth's "biocode" -- across human and natural ecosystems. We link these genetic data to other biophysical and socioeconomic data and integrate the resulting information in predictive models. These models aim to map the quality and distribution of biodiversity and the ecosystem services it provides under various scenarios of human activity.
□ synt_biology:
What happened to personalized medicine? : Nature Biotechnology : Nature Publishing Group bit.ly/xIUZVl
Personalized medicine falls a long way short of the predictive and preventative healthcare paradigm it once promised.
□ Equinox:
Ever wonder what your genes are trying to tell you? A new service exclusively at Equinox helps translate: buzz.mw/_3pdGu #Qblog
I handed my specimen to Berenc, who forwarded it on to Existence Genetics (EG), an LA-based company that developed what it calls a Nexus DNA Gene Chip, which purportedly can detect a large number of disease-causing variations in the human genome.
□ PathwayGenomics:
Pathway scientist collaborates with Salk Institute, helps discover gene crucial to lung and brain development cot.ag/zTwrif
The course covers Stochastic Programming, Optimization Methods in Finance (Quadratic and Integer Programming and Linear and Nonlinear Programming), Sparse Principal Components Analysis, and Kernel-Based Learning. There is also includes an introduction to the new ROI (R Optimization Infrastructure) package, which provides a unified interface to the many solvers available in R. Course slides (in English), R code and example data are all available at the course website linked below.
□ Optimization in Finance: Linear and Nonlinear Programming (Stefan Kerbi)
>> http://t.co/7il35kXr [pdf]
・ asset liability management
・ portfolio selection (mean variance optimization)
・ risk management and again portfolio selection (actually the same: only variance substituted by a different risk measure)
・ pricing of options and hedging with derivatives, finding of arbitrage possibilities
・ via the intermediate purpose of statistics (e.g. ML-estimation)
□ SpringerSysBio:
Check out newly published Introduction to #Data Mining for the #Life #Sciences bit.ly/xGxByz. Great for beginners! #bioinformatics
□ ayrrisbio:
#BigData in small places - Nature posts article regarding how to work with large data sets systematically bit.ly/wJlEOu HT @Kamou
In our experience, many biologists initially approach bioinformatics methods as a set of black box tricks in which the basic rules of rigorous experimentation somehow don't apply. Perhaps it is the mathematical comfort zone provided by E-scores and P-values that gives a false sense of absolute accuracy to the results of bioinformatics analyses, but it is puzzling how careful bench biologists turn into naive experimentalists once they sit at the computer.
Bioinformaticians can have the strongest effect on proper use of bioinformatics practices by helping in the design and execution of experiments and controls.
□ Twitterなどソーシャルメディアを辿って感染症の拡がりを即時的に追跡 / Correlation of socialmedia & epidemiology / Tracking infectious diseases on Twitter http://bit.ly/xnevnY
Thousand Mile Stare CD Album
01. Windbreaks
02. Thousand Mile Stare
03. Playing Fields feat. Kate Walsh
04. Going Deep (moogmonkey remix)
05. Goldfish
06. Flotsum & Jetsum
07. Super Mouflon
08. Going Deep (Original mix)
09. Fin des Jours
Demo USB/Cassette
01. What am I doing here prt 1 (early demo male vox)
02. Santanas
03. Where do i start (rough demo)
04. Jumbo
05. Playing Fields (beatless demo)
06. Stoned/hybrid (acoustic idea)
07. La Luna
08. The Bee
09. Flyover
10. 1000 mile (initial sketch)
11 1000 mile (alternate melody)
12 Offshore (live intro demo)
13 MoJavé
All Mixed Up
01. Offshore (Man called Adam Remix)
02. What am I doing here Prt 1 (McAuley & Walsh Remix)
03. Hiding all the Stars (Michael Woods Remix)
04. Locking Down (Dum Dum Project feat. The 1Shanti Remix)
05. Bruised Water (Adam K & Soha Dub)
06. Come Tomorrow (Soul Seekerz Dirty Dub)
07. Autumn Tactics (Thrillseekers Remix)
08. Come Back (Shockone Remix)
09. Where do I start (Armin Van Burren Remix)
10. Poppiholla (Freakazoid Remix)
11. Locking down (Niraj Feat Teymour Housego Remix)
“Thousand Mile Stare - the album, the remix album and the demo's form a very rounded picture of the artist, or artistry, which really equates to talent and bloody hard work.” -Louis, excerpt from A4 Booklet.
Chicane - Nick Bracegirdleをトランス・レジェンドの系譜に含めることに吝かでない向きも多いだろうが、今作のブックレットにあるように、彼の音楽性をジャンルで定義づけること自体ナンセンスだと認める人々もまた、クラブ・カルチャーとは無縁な所で多数存在することも確かだ。
一曲目"Windbreaks"は、お家芸の爽やか系アンビエント。どこか懐かしい感情を煽るベルの音色に誘われて、雲間から射す光のようなアトモスフィアが世界に色を与える。メロディラインが前作の"What Am I Doing Here?"からの引用。後半のドラムの疾走感が、これまでのイントロトラックと一線を画す。
track.2は表題曲。Solarstoneの"7 Cities"のリメイクといって良いほどソックリ。"Demos"では、序盤のピアノリフのスケッチや変遷が確認出来る。"Flotsum & Jetsum"でも、"Where do i start"の旋律がリユースされており、Chicaneの豊穣なインスピレーションと、その試行の数々を目の当たりに出来る。
Alternatively, it may be desirable to cloak the occurrence of an event over a finite time period, and the idea of temporal cloaking has been proposed in which the dispersion of the material is manipulated in time, producing a ‘time hole’ in the probe beam to hide the occurrence of the event from the observer.
□ strataconf:
How we communicate information: Visualization & Interface sessions at #Strataconf can help you do it right bit.ly/vZJmbY
□ GenomicsIo:
New NIH genetics center focuses its lens on exome, despite doubts zite.to/yJsU1C via @zite
Less than half of the more than 7,000 heritable diseases identified thus far have a known genetic origin. So, on 6 December, to help pinpoint the DNA glitches behind these disorders and thereby hasten diagnosis and drug development, the Bethesda, Maryland?based US National Human Genome Research Institute (NHGRI) and National Heart, Lung, and Blood Institute announced the funding of the Mendelian Disorders Genome Centers Program, part of a larger bundle of genomics grants totaling more than $400 million toward projects it has also supported in the past.
Increasingly, given technological advances, scientists are advocating whole-genome sequencing over exome sequencing. Although the latter only contains one-fiftieth of the sequence length analyzed, about the cost saving is only half, at around $2,500 compared with $5,000 for the whole genome. This is because it is more expensive and labor intensive to process genetic material for exome sequencing,
Physicists Carol Tanner and Steven Ruggiero led the team in the application of a new technique called laser transmission spectroscopy (LTS). LTS is capable of rapidly determining the size, shape and number of nanoparticles in suspension.
the team describes how they applied LTS as a novel method for detecting species-specific DNA where the presence of one invasive species was differentiated from a closely related invasive sister species.
□ ayrrisbio:
"Data is the 4th paradigm of science" - @derrickharris gives insight on #BigData bit.ly/yvm5QO 5 deep insights on big data
Hadoop is great and companies need to start analyzing all their data lest they risk losing their competitive edge. Gotcha. But there’s a heck of a lot more to think
□ Bioinformatic5:
Updated: Biomedical Research Insider: Data Integration platforms - Research and Service Delivery - Oracle bit.ly/xPavyV
Certainly the 'Omics platform is indicative of their aim to get to work in the translation medicine area (described as the North Star of their current thrust) - but it's an undeveloped product, not even fully implemented at Moffitt as far as we are aware. And that will be its first implementation - Moffitt hinted that this was the missing component in the Oracle solution the first time round.
We provide efficient, easy-to-use tools for High-Throughput Sequencing (ChIP-seq, RNAseq etc.). These include MDS plots (analogues to PCA), detecting inefficient immuno-precipitation or over-amplification artifacts, tools to identify and test for genomic regions with large accumulation of reads, and visualization of coverage profiles.
□ Rational Design of CRISPR RNAs that Function with the Cas RAMP Module Complex to Cleave RNAs http://bit.ly/wIlFur
We also present data that indicate that the Cmr complex cleaves an endogenous complementary RNA in Pyrococcus furiosus, providing direct in vivo evidence of RNA targeting by the CRISPR-Cas system. Our findings indicate that the CRISPR RNA-Cmr protein pathway may be exploited to cleave RNAs of interest.
ROLL up, roll up: the biobank is open for business. Medical, lifestyle and genetic data from 500,000 middle-aged Britons is to be made available to medical researchers worldwide through the Biobank UK project, which has spent five years recruiting volunteers.
□ SOLiDSequencing:
Life Tech Provides SOLiD Platform for University of Strasbourg's Genomax Project ow.ly/8iuRo
According to Seiamak Bahram, head of Genomax and a professor of immunology at Strasbourg University Hospital, "hundreds" of blood samples have been sequenced on the SOLiD platform, providing "an invaluable insight into the most common diseases."
Life Tech社が、ストラスブール大学のGenomaxプロジェクトにSOLiDプラットフォームを提供。総額140万ドルの資金援助を得て、数千のサンプルを管理するトランスレーショナル・バイオバンクの構築へ。地方自治体からも投資かぁ
□ Mol_Med:
40 Most Awesome iPad Apps for Science Students. ow.ly/7S8VT
『理系学生がインストールすべきiPadアプリ40選』定番がズラリと並ぶが、ReferenceでWolfram Alphaが二位に甘んじたのが意外。BiologyにランクインしたGeneIndexHDは最近PLoSでも取り上げられてた。
□ Preparation of high-quality next-generation sequencing libraries from picogram quantities of target DNA
New sequencing technologies can address diverse biomedical questions but are limited by a minimum required DNA input of typically 1 μg. We describe how sequencing libraries can be reproducibly created from 20 pg of input DNA using a modified transpososome-mediated fragmentation technique.
Yesterday, I heard about a bill introduced in December in the House of Representatives entitled the "Research Works Act." The bill catalyzed an open conversation on Twitter between Tim O'Reilly and Darrell Issa about H.R. 3699.
