The Biology of Genomes 2011. (May 10-14)

□ Cold Spring Harbor Laboratory: The Biology of Genomes 2011. (Day-1.)

>> http://meetings.cshl.edu/meetings/genome11.shtml

The 2011 meeting will address DNA sequence variation and its role in molecular evolution, population genetics and complex diseases, comparative genomics, large-scale studies of gene and protein expression, and genomic approaches to ecological systems.

□ CSHLnews: ColdSpringHarborLab: Biology of Genomes 2011 Meeting
MT: For those following Biology of Genomes 2011 at #bg2011, also keep an eye on @lukejostins at http://bit.ly/lsyYaH



□ dgmacarthur: 膨大な遺伝子データを保有していても、シーケンスからレベル予測に至れないのは何故か？
Barak Cohen: we know a huge amount about gene expression, but still can't predict levels from sequence. Why not? #bg2011



□ lukejostins: Luke Jostins
TG: The number of predicted human genes (~50K, with ~20K protein coding ) has been stable for the last two years. #BG2011



□ lukejostins:
Jason Ernst is talking about using ENCODE epigenomic mapping to shed light on GWAS hits #BG2011



□ eurogene:
Genomics: A guided tour of the genome : ENCODE - Nature http://bit.ly/l2M2ZD




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□ TriLinkBioTech:
"In essence, science is a perpetual search for an intelligent and integrated comprehension of the world we live in." - Van Neil





((NasdaqGS: ILMN)

□ portablegenomic: Ilumina社IGN、全ゲノムシーケンスのコスト低減
Illumina Reduces Price of Whole Human Genome Sequencing Through Illumina Genome Network down to $5000 finance.yahoo.com/news/Illumina-… (May 9, 2011, 6:00 am EDT)

Illumina, Inc. (NASDAQ:ILMN - News) today announced that it is significantly reducing the price for sequencing whole human genomes through the Illumina Genome Network (IGN). The new list price for the service is $5,000 per genome for projects of ten samples or more, and $4,000 for projects of fifty samples or more.

□ DailyNewsGW: 米Fluidigm社が第1四半期30%成長を達成。シングルセル研究の高まりとBioMark需要。R&Dは横ばい。
Fluidigm's Q1 Revenues Climb 30 Percent: The firm's product revenues were up 34 percent, while grant and collabo... http://bit.ly/kAOAKF

>> http://www.fluidigm.com/

"We experienced strong interest in single-cell genomics, genotyping consumables, and sample preparation for next-generation sequencing," Fluidigm President and CEO Gajus Worthington said in a statement. "More than half of the BioMark and new BioMark HD Systems sold during Q1 are being used to conduct single-cell research."

Fluidigm finished the quarter with cash and cash equivalents of $55.8 million and available-for-sale securities of $21.9 million.

□ DailyNewsGW: ライフテクノロジーズ日本、遺伝子解析PCR装置のマーケティング・クリアランス付与
Life Technologies Gets Japan OK for 7500 Fast Dx, 3500 Dx Instruments: read more http://bit.ly/kalKs4






□ iainh_z: 地域・組織間の医療データ共有バイオグリッド構想
NCRI Informatics Initiative spring newsletter http://bit.ly/mwZTx3 including a feature on data sharing and publication in #bmcresnotes

>> http://www.cancerinformatics.org.uk/

Refresh ?BioGrid Australia and the Australian Cancer Grid

Funded by the Victorian and Austral- ian Governments and led by clinical researchers, BioGrid is a not-for-profit data sharing technology organisation spanning a network of 41 hospitals and research organisations. BioGrid seeks to facilitate the improvement of health outcomes by providing easier access to health and research data across multiple institutions, geographic regions and dis- eases through the secure and ethical inte- gration of data.

□ eurogene: ゲノムワイド関連解析の表現型データサンプルサイズ縮小。
obesity as a trait in GWAS - use of extreme phenotypes enables small(ish) sample sizes say authors result http://1.usa.gov/m6Z5eA




□ sciam: Scientific American: 人間の『目』に隠された概日リズムと感情制御組織
Hidden Organ In Our Eyes Found to Control Circadian Rhythms and Emotions (preview) http://bit.ly/l204le






□ DebbieKennett: DNA解析によると、1万4千年前の北アメリカ人口は70人に満たなかった。
DNA research suggests that North America was populated by no more than 70 people 14,000 years ago: http://tinyurl.com/6ctslz8




□ oatp: OA Tracking Project
BioMed Central's 5th Annual Research Awards, and the winners are...: ""The winners of our [BioMed Central's] 5th... http://bit.ly/kAMzeF




□ PLoS: 　情報：『フリー』であることと『オープン』であることの違い。
Understanding the difference between Free and Open Access http://tinyurl.com/freevsopen




□ openmeti_e: 東日本大震災対応アプリケーション開発プロジェクト
Open Government Laboratory to launch the “Apps for Japan” Project http://openlabs.go.jp/apps4japan/ #opengovjp #gov20 #opengov

As a first step, METI is cooperating with “Tasukeai Japan”. We are calling for the development of websites and apps that will make available the volunteering information provided by this organization.

In addition, we are presently considering options for projects aimed at addressing the expected rise in electricity demand during the summer. As with previous apps aimed at addressing the electricity situation, information on these projects will be provided through Twitter.

□ scholarlykitchn: 市場原理: ソーシャルメディアはツールであって戦略ではない。
Rely on marketing principles -- not trendy ideas. Social media is a tool, and a tool is not a strategy. http://ow.ly/4Re03 via @DUKEpress




□ PLoSCompBiol:
Web Tools for Searching the Biomedical Literature ? part I blogs.plos.org/mfenner/2011/0…

>> http://www.ncbi.nlm.nih.gov/CBBresearch/Lu/search/

The author describes 28 tools developed specifically for the biomedical domain. The tools are grouped based on their most important features into

1. Ranking search results
2. Clustering results into topics
3. Extracting and displaying semantics and relations
4. Improving search interface and retrieval experience

□ OxfordJNLsJapan:
【医学・ニコチン学】米・英の大手タバコ会社が食欲抑制剤をタバコに添加していたことが判明。禁煙すると体重が増加しやすくなる理由に。http://oxford.ly/jnMf4E

a systematic search within the archives of six major US and UK tobacco companies (American Tobacco, Philip Morris, RJ Reynolds, Lorillard, Brown & Williamson and British American Tobacco) that were Defendants in tobacco litigation settled in 1998.

Findings are dated from 1949 to 1999. Results: The documents revealed the strategies planned and used by the industry to enhance effects of smoking on weight and appetite, mostly by chemical modifications of cigarettes contents. Appetite-suppressant molecules, such as tartaric acid and 2-acetylpyridine were added to some cigarettes.

日本では全く報道されていない気がする。酒石酸と2-アセチルピリジンを意図的に添加。タバコで「痩せる」イメージ戦略に。内部資料によると、1949-1999年の間に食欲抑制剤をタバコに無表記で添加しつづけたことが示されている。重要なのは、それを中止したという記録もなく、直近のデータが提出されたわけでもないとのこと。

日本のタバコ会社が同じことをしているとは断定できないけど、「禁煙したら食欲が出てしょうがない」なんて話は幾らでも聞くよね。