腫瘍壊死因子（TNF）阻害薬による治療を受ける関節リウマチ患者は、癌（がん）および重篤な感染症を発症するリスクが高いことが明らかになった。ヘルスデージャパン2006-05-16
Bioactive Constituents from Chinese Natural Medicines. XV.
HInhibitory Effect on Aldose Reductase and Structures of Saussureosides A and B from Saussurea medusaa
Hihui Xie1), Tao Wang1), Hisashi Matsuda1), Toshio Morikawa1), Masayuki Yoshikawa1) and Tadato Tani2)
1) Kyoto Pharmaceutical University
2) Department of Kampo-pharmaceutics, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
The 80% aqueous acetone extract from the whole plant of Saussurea medusa MAXIM. was found to inhibit rat lens aldose reductase (IC50=1.4 μg/ml). From this extract, flavonoids, lignans, and quinic acid derivatives were isolated together with two new ionone glycosides, saussureosides A and B. Their absolute stereostructures were elucidated on the basis of chemical and physicochemical evidence including the application of modified Mosher's method. In addition, some isolates were found to show an inhibitory effect on aldose reductase. J-Stage＞＞JOI JST.JSTAGE/cpb/53.1416
HInhibitory Effect on Aldose Reductase and Structures of Saussureosides A and B from Saussurea medusaa
Hihui Xie1), Tao Wang1), Hisashi Matsuda1), Toshio Morikawa1), Masayuki Yoshikawa1) and Tadato Tani2)
1) Kyoto Pharmaceutical University
2) Department of Kampo-pharmaceutics, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
The 80% aqueous acetone extract from the whole plant of Saussurea medusa MAXIM. was found to inhibit rat lens aldose reductase (IC50=1.4 μg/ml). From this extract, flavonoids, lignans, and quinic acid derivatives were isolated together with two new ionone glycosides, saussureosides A and B. Their absolute stereostructures were elucidated on the basis of chemical and physicochemical evidence including the application of modified Mosher's method. In addition, some isolates were found to show an inhibitory effect on aldose reductase. J-Stage＞＞JOI JST.JSTAGE/cpb/53.1416
武田薬品工業の子会社、和光純薬工業（大阪市）は３１日、アルツハイマー病の原因物質とされるたんぱく質「ベータアミロイド４２」（Ａ●４２）の血液中濃度を測定する試薬キットを開発したと発表した。朝日新聞 2006年05月31日 和光純薬ニュースリリース
１５種類の遺伝子情報（ＤＮＡマーカー）を調べることにより、国内外で流通、保存されている約７０種のイチゴの品種識別ができる技術を、独立行政法人野菜茶業研究所（津市安濃町）が開発した。新品種の識別にも対応でき、同研究所は「品種の偽装表示防止に有効な画期的技術」としている。毎日新聞MSN 2006年5月31日