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微生物によるコハク酸製造技術

2006年12月04日 | 菌類 細菌
Kinetic study for the extraction of succinic acid with TOA in fermentation broth; effects of pH, salt and contaminated acid
  Young-Si Jun,et.al.,
Biochemical Engineering Journal:In Press, Corrected Proof, Available online 15 November 2006
Reactive extraction can be used for the recovery of carboxylic acids from fermentation broth. Through the formation of complex with extractants at the two-phase interface, the carboxylic acids are partitioned into organic solvents. However, the recovery of carboxylic acids is interrupted by the conditions of fermentation broth. In this study, the effects of conditions of fermentation broth on the extraction kinetics were investigated using a microporous membrane-based stirred cell for the extraction of succinic acid with tri-n-octylamine.

Succinic acid production from Bacteroides fragilis: Process optimization and scale up in a bioreactor
  Anaerobe, Volume 12, Issues 5-6, October-December 2006, Pages 231-237
  Jasmine Isar, Lata Agarwal, Saurabh Saran and Rajendra Kumar Saxena
 We report the effect of different physiological and nutritional parameters on succinic acid production from Bacteroides fragilis. This strain initially produced 0.70 g L−1 of succinic acid in 60 h. However, when process optimization was employed, 5.4 g L−1 of succinic acid was produced in medium consisting of glucose (1.5%); tryptone (2.5%); Na2CO3 (1.5%), at pH 7.0, when inoculated with 4% inoculum and incubated at 37 °C, 100 rpm for 48 h.

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