OC43に対する抗体が、SARS罹患中に増加していたという報告

香港大学の論文で、冷凍保存しておいたSARSの患者の血清に、MERSに対する抗体があるかどうか調べた実験で、同時にOC43に対する抗体も調べています。

4人のSARS患者は急性期と回復期の血清が保存してあったのですが、OC43 に対する抗体が、急性期から回復期にかけて急増していました。

プラマー博士の論文の結果（OC43に罹患中、SARSに対する抗体が増加した）と比較してみたいと思います。

Cross-reactive antibodies in convalescent SARS patients

A severe acute respiratory syndrome (SARS)-like disease due to a novel betacoronavirus, human coronavirus EMC (HCoV-EMC), has emerged recently. HCoV-EMC is phylogenetically closely related to Tylonycteris-bat-coronavirus-HKU4 and Pipistrellus-bat-coronavirus-HKU5 ...

Cross-reactive antibodies in convalescent SARS patients

Summary

Objectives

A severe acute respiratory syndrome (SARS)-like disease due to a novel betacoronavirus, human coronavirus EMC (HCoV-EMC), has emerged recently. HCoV-EMC is phylogenetically closely related to Tylonycteris-bat-coronavirus-HKU4 and Pipistrellus-bat-coronavirus-HKU5 in Hong Kong. We conducted a seroprevalence study on archived sera from 94 game-food animal handlers at a wild life market, 28 SARS patients, and 152 healthy blood donors in Southern China to assess the zoonotic potential and evidence for intrusion of HCoV-EMC and related viruses into humans.

Methods

Anti-HCoV-EMC and anti-SARS-CoV antibodies were detected using screening indirect immunofluorescence (IF) and confirmatory neutralizing antibody tests.

Results

Two (2.1%) animal handlers had IF antibody titer of ≥1:20 against both HCoV-EMC and SARS-CoV with neutralizing antibody titer of

Conclusions

Convalescent SARS sera may contain cross-reactive antibodies against other betacoronaviruses and confound seroprevalence study for HCoV-EMC.