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新型コロナワクチンの開発を、『マンハッタン計画』と呼ぶ人たちがいた

HPVのL1遺伝子のメチル化とCINの予後

2017-08-31 | 論文
この論文では、HPV-16, -18, -31, -52, -58型で調べているが、
日本では52型と58型が多い
 
http://images.journals.lww.com/ijgc/Original.00009577-201302000-00004.TT1.jpeg
 
 
 
Int J Gynecol Cancer. 2013 Feb;23(2):235-43. doi: 10.1097/IGC.0b013e31827da1f6.

L1 gene methylation in high-risk human papillomaviruses for the prognosis of cervical intraepithelial neoplasia.

Author information

1
Section of Translational Research, Hyogo Cancer Center, Akashi, Japan.

Abstract

OBJECTIVE:

The purpose of this study was to investigate the clinical significance of DNA methylation of the human papillomavirus (HPV) genome as a prognostic biomarker for cervical intraepithelial neoplasia (CIN).

METHODS AND MATERIALS:

Clinical samples (paraffin-embedded tissues obtained by conization/hysterectomy or initial punch biopsy) were collected from patients at the Gynecologic Oncology of the Hyogo Cancer Center with informed consent. We evaluated the methylation status of the L1 gene of the HPV genome by bisulfite sequencing, calculating the methylation ratio (L1MR) as (number of methylated CpGs in the analyzed region of the L1 gene) / (number of all CpGs in the analyzed region of the L1 gene) × 100. The methylation analysis and in situ hybridization were performed with serial tissue-section slices.

RESULTS:

DNA methylation was observed in the L1 gene, but not in the long control region of HPV-16, -18, or the other high-risk HPV types including HPV-31, -52, and -58. L1MR was associated with the CIN grade; the median L1MR was 2.3%, 11.2%, 35.2%, and 50.0% for CIN1, CIN2, CIN3, and squamous cell carcinoma, respectively. L1MRs also seemed to indicate physical status (integrated or episomal form) of the HPV genome in the host cell. L1MR of the progression group was significantly higher than that of the regression group.

CONCLUSIONS:

L1MR was associated with the CIN grade and indicated the HPV genome status in the host cell: high L1MR indicated HPV genome integration linked to progression from early-stage CINs, whereas low L1MR indicated an episomal HPV genome location in host cells. L1MR may be a prognostic indicator of CIN.

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HPVのL1のDNAがメチル化されている程度が、CINの重症度と関連するという報告

2017-08-31 | 論文

慶応大学からの報告、HPV52型と58型でメチル化の程度を調べている

他の国では、HPV16型で調べて報告している例が多数

日本はやはり52型と58型が蔓延しているのか?

 
J Clin Virol. 2013 Sep;58(1):149-54. doi: 10.1016/j.jcv.2013.06.026. Epub 2013 Jul 17.

Methylation of human papillomavirus-52 and -58 is a candidate biomarker in cervical neoplasia.

Author information

1
Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Abstract

BACKGROUND:

Previous studies of human papillomavirus (HPV)16/18 genome methylation have concluded that methylation status of the L1 gene might act as a biomarker for cervical intraepithelial neoplasia (CIN).

OBJECTIVES:

We investigated the correlation between methylation status in the L1 gene and the long control region (LCR) of HPV52/58 and CIN.

STUDY DESIGN:

Exfoliated cervical cells were taken from 54 HPV52-positive and 41 HPV58-positive women. The HPV genome was examined using bisulfite modification, polymerase chain reaction amplification, and sequencing.

RESULTS:

The CpGs were unmethylated or hypomethylated in the HPV52/58 LCR. In contrast, the methylation status of the HPV52 L1 gene was correlated with the severity of cervical neoplasia, with average percentages of 15%, 34%, and 52% for cervicitis/CIN1, CIN2, and CIN3, respectively (P<0.05). Methylation status of the HPV52 L1 gene was also correlated with the prognosis of CIN1/2, with median percentages of 15% and 35% for regression and persistence/progression, respectively (P<0.05). The methylation status of the HPV58 L1 gene was correlated with the severity of cervical neoplasia, with average percentages of 12%, 38%, and 61% for cervicitis/CIN1, CIN2, and CIN3, respectively (P<0.05).

CONCLUSIONS:

The increased methylation at the CpG sites in the HPV52/58 L1 gene was correlated with the severity of cervical neoplasia, similar to HPV16/18 in previous studies. These data suggest that HPV methylation status of the L1 gene is a candidate biomarker of CIN for detecting CIN2 and CIN3.

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HPVの型の中の系統の頻度を調査した研究

2017-08-30 | ブログ
日本を含む東アジア諸国では、子宮頸部上皮内腫瘍および浸潤性子宮頸がんの患者において、HPV52型と58型が頻繁に検出される
 
 
 
Infect Agent Cancer. 2017 Aug 4;12:44. doi: 10.1186/s13027-017-0155-4. eCollection 2017.

Whole-genome analysis of human papillomavirus genotypes 52 and 58 isolated from Japanese women with cervical intraepithelial neoplasia and invasive cervical cancer.

Abstract

BACKGROUND:

Human papillomavirus genotypes 52 and 58 (HPV52/58) are frequently detected in patients with cervical intraepithelial neoplasia (CIN) and invasive cervical cancer (ICC) in East Asian countries including Japan. As with other HPV genotypes, HPV52/58 consist of multiple lineages of genetic variants harboring less than 10% differences between complete genome sequences of the same HPV genotype. However, site variations of nucleotide and amino acid sequences across the viral whole-genome have not been fully examined for HPV52/58. The aim of this study was to investigate genetic variations of HPV52/58 prevalent among Japanese women by analyzing the viral whole-genome sequences.

METHODS:

The entire genomic region of HPV52/58 was amplified by long-range PCR with total cellular DNA extracted from cervical exfoliated cells isolated from Japanese patients with CIN or ICC. The amplified DNA was subjected to next generation sequencing to determine the complete viral genome sequences. Phylogenetic analyses were performed with the whole-genome sequences to assign variant lineages/sublineages to the HPV52/58 isolates. The variability in amino acid sequences of viral proteins was assessed by calculating the Shannon entropy scores at individual amino acid positions of HPV proteins.

RESULTS:

Among 52 isolates of HPV52 (CIN1, n = 20; CIN2/3, n = 21; ICC, n = 11), 50 isolates belonged to lineage B (sublineage B2) and two isolates belonged to lineage A (sublineage A1). Among 48 isolates of HPV58 (CIN1, n = 21; CIN2/3, n = 19; ICC, n = 8), 47 isolates belonged to lineage A (sublineages A1/A2/A3) and one isolate belonged to lineage C. Single nucleotide polymorphisms specific for individual variant lineages were determined throughout the viral genome based on multiple sequence alignments of the Japanese HPV52/58 isolates and reference HPV52/58 genomes. Entropy analyses revealed that the E1 protein was relatively variable among the HPV52 isolates, whereas the E7, E4, and L2 proteins showed some variations among the HPV58 isolates.

CONCLUSIONS:

Among the HPV52/58-positive specimens from Japanese women with CIN/ICC, the variant distributions were strongly biased toward lineage B for HPV52 and lineage A for HPV58 across histological categories. Different patterns of amino acid variations were observed in HPV52 and HPV58 across the viral whole-genome.

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2 ALS Cases May Be Linked to Gardasil Vaccine

2017-08-29 | 資料

日本でのサーバリックス後の症例

http://blog.goo.ne.jp/hazukimutsukinagatsuki/e/b41bd1ae90a4f8f6919a14ed7d5d500e

 

Researchers Believe Cervical Cancer Vaccine Could Be Linked to Cases of Lou Gehrig's Disease

http://www.webmd.com/sexual-conditions/hpv-genital-warts/news/20091016/rare-disease-may-be-linked-vaccine#1

Oct. 16, 2009 (Baltimore) -- Researchers believe that there may be a link between a vaccine against cervical cancer and a rapidly progressive, fatal disease in two young women.

Both the timing of the symptoms and autopsy results “suggest a link between” the Gardasil vaccine and the fatal cases of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, says Catherine Lomen-Hoerth, MD, director of the ALS Center at University of California San Francisco Medical Center.

With only two confirmed cases, “we don’t know for sure if it’s coincidence or if they’re connected [to the vaccine],” she tells WebMD. “We hope that by raising awareness, we will become aware of any other cases."

Pam Eisele, a spokeswoman for Merck & Co., which makes the vaccine, says the company cannot comment specifically on the cases as it has not seen the data.

“However, after carefully reviewing all the information available to us about reported adverse events, including reports of deaths, Merck does not believe these events have been caused by Gardasil,” she says.

The vaccine has been given to more than 7 million girls and young women nationwide.

Gardasil and ALS: Jenny’s Story

The tragic story of one of the girls, Jenny Tetlock, is chronicled on “Jenny’s Journey,” a web site created by her parents to publicize her case and get others with similar symptoms to come forward.

The first sign that something was wrong was when 14-year-old Jenny tripped on a hurdle that others in her class cleared easily, according to the web site. That was just months after her third and final booster Gardasil shot, Lomen-Hoerth says.

The disease rapidly progressed; both her legs, and then her arms became weak, Lomen-Hoerth continues. Jenny began to limp and had trouble gripping objects. She felt pins and needles in her feet, and her muscles atrophied, she tells WebMD.

 

Within a year, Jenny was paralyzed, a quadriplegic breathing only with the help of life support. She died shortly afterward, Lomen-Hoerth says.

Throughout the course of her illness, Jenny’s mind was as sharp as ever, she adds.

The other patient, a 20-year-old, developed similar symptoms within four months of her first Gardasil shot, Lomen-Hoerth says. The disease followed a similar course, and the girl died 28 months later.

 

Rapidly Progressive Course

In addition to the short time span between vaccination and the onset of symptoms, several other factors made the researchers suspect a link to Gardasil vaccination, Lomen-Hoerth says.

In both young women, the disease progressed more quickly than typical for young ALS patients, she says.

Additionally, at autopsy, “we were surprised that the spinal cord was so inflammatory. That is very different from what we normally see in ALS,” she says.

The pathology features “all support a temporal association between [the illness] and vaccination,” Lomen-Hoerth says.

She spoke at the annual meeting of the American Neurological Association.

Because it is extremely rare, affecting just one in 2-3 million young people, there are very few studies of juvenile ALS, Lomen-Hoerth says.

Her team plans further study comparing the symptoms and pathological features of young adults with ALS who got the Gardasil vaccine to those who didn’t get the shots. “If the features are identical, then we’ll know [the vaccine] is not the cause,” Lomen-Hoerth says.

In the meantime, she and colleagues have met with scientists from the FDA and CDC to scour their adverse-event database, called the Vaccine Adverse Event Reporting System (VAERS), for any other reports linking ALS to Gardasil or other vaccinations. “So far, we haven’t found any,” she says.

Merck is also continuing to work with the CDC and FDA to monitor any adverse events that may have been caused by the vaccine, according to Eisele.

Yadollah Harati, MD, a neurologist at Baylor College of Medicine in Houston, says the findings raise a red flag.

The fact that “the postmortem studies show distinct immunological features different from what is typical of ALS” suggest an association between vaccination and ALS, he says.

“I will be asking any of my young patients with ALS whether they received the Gardasil vaccine,” he tells WebMD. “I have one 20-year old ALS patient, and we didn’t think to ask that.”

 

日本でも本当に残念なことにALSで死亡したケースがありました。

ほんとうにすごい免疫賦活は起こるんですよ。ワクチンの後。だから有害な事象になるかはわからない。遺伝性ALSなんだけど発症してすぐに亡くなってしまった患者さんも経験しました。そういう例は複数あるんです。

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HPVワクチン後の白血病

2017-08-28 | VAERSから

HPVワクチン後の白血病の報告が多い

HTLV-1キャリアの可能性がある人(九州出身の縄文系の人)は注意が必要ではないのか

サーバリックス 8件 (ガーダシルとの比率から考えると発症率高)

ガーダシル 27件

B型肝炎 24件

 

https://ja.wikipedia.org/wiki/%E6%88%90%E4%BA%BAT%E7%B4%B0%E8%83%9E%E7%99%BD%E8%A1%80%E7%97%85

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GSKは、アリババと提携してサーバリックスを中国で売ることになった

2017-08-28 | ブログ

http://www.fiercepharma.com/vaccines/glaxosmithkline-partners-alibaba-for-china-hpv-vaccine-market-grab

But there is some upside for GSK. According to the bidding price GSK has reached with several provincial authorities, Cervarix costs 580 Chinese yuan per shot, meaning the three-jab regimen amounts to 1,740 Chinese yuan ($260). Patients will be paying slightly more than that after additional fees. Gardasil, though not yet launched in the country, has reached the price of 798 Chinese yuan per shot, or about 38% higher than that of Cervarix, with some local governments.

 

サーバリックスの価格は、3回接種で28600円

ガーダシルは、3回接種で39000円

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中国におけるサーバリックスとガーダシルの戦い

2017-08-28 | ブログ

http://www.fiercepharma.com/vaccines/merck-s-gardasil-heads-against-gsk-s-cervarix-china-first-year-sales-planned-at-166m

Nevertheless, at least for now, there's one thing that Cervarix could differentiate itself from Gardasil in China, and that's approved target age groups. CFDA approved Cervarix for immunization in women ages 9 to 25, but Gardasil's current approval is for females ages 20 to 45, different from its U.S. FDA's approval for those 9 through 26. Given that the primary target group in most of the countries recommending HPV vaccination is young adolescent girls aged 9 to around 14 (before they're sexually active), Cervarix could offer more potential. But it's likely that Gardasil will seek approval expansion.

中国では、サーバリックスは、9歳から25歳の女性への接種に承認されたが、ガーダシルは20歳から45歳の女性に承認されている。本国のアメリカでは、9歳から26歳である。

 

 

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ガーダシルに添加されているDNAはアジュバントなのか

2017-08-23 | 資料

2016年に日本の厚労省の難波江氏がデータを隠匿させたことを指摘するメールが、アメリカの研究者シン・リー博士からWHOに送付されましたが、そのメールの中で、検査したすべてのガーダシルのアンプルにDNAが含まれていたことが報告されていました。

http://sanevax.org/wp-content/uploads/2016/01/Allegations-of-Scientific-Misconduct-by-GACVS.pdf

 

bokemontaro先生のツイッターでご紹介の論文の中に、DNAがアジュバントとして作用することが書いてありましたので資料としてご紹介します。

 

横山 和正, 服部 信孝:神経疾患におけるワクチンの功罪. 順天堂醫事雑誌 60 (2014) Suppl.2 p. s53-s59

https://t.co/IvTr4N7bHX

審良静男らが明らかにしたDNAワクチンのメカニズムは,まずDNAの右巻きの二重らせん構造(B-DNA)が細胞内でTank-Binding Kinase 1(TBK1)という酵素(シグナル伝達分子)を介して自然免疫系を活性化することで,ワクチンの内因性アジュバントとして作用するということである.また,DNAワクチンの効果のうち,抗体の産生のためには樹状細胞などの免疫細胞でのTBK1依存性の自然免疫活性化が重要で,T細胞による細胞性免疫の活性化のためにはDNAを取り込んだ筋肉細胞などの非免疫細胞でのTBK1の活性化が重要であるとしている.このような報告事実から抗原特異的療法による免疫の制御は非常に難しく,どの抗原をいつどのようなルートで投与するかはまさにギャンブルといっても良いかもしれない.やめどきを含めて評価と選択が重要である.

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bokemontaro先生のツイッターから

2017-08-21 | 資料

国立病院機構静岡てんかん・神経医療センターの高橋幸利先生のグループの素晴らしい臨牀研究、基礎実験報告の総説。世界に先駆けて、HPVワクチン接種後にみられる中枢神経系関連症状の解析と実験モデルでの検討。Editorialを書かれた山村隆先生は自己免疫学の権威。新病態の認知を意味する

 

患者背景:39例中7例(17.9%)喘息→Th2シフトしやすい素因の存在、成育歴:精神的ストレス体験(長期に亘るいじめなど)18例(46%)→ストレスによる免疫細胞の脳への移動が気分や行動に影響→強度のストレス体験の有無の聴取は神経免疫病態の関与を疑うきっかけとなる。

 

中枢神経系関連症状:因果関係は確定できないが、32症例の発病年齢は15.0±1.5歳で、初回接種後9.4±8.1カ月であった。認知機能障害は26/32(81%)、運動機能障害24例(75%)に認められ、歩行障害、突然の脱力による転倒、ミオクローヌスや振戦等の不随意運動が多かった。

 

脳神経障害は16例(50%)、聴覚障害やめまいが多かった。知覚障害は11例(34%)、感覚障害、痺れ、掻痒、味覚障害が多かった。その他には、過換気症候群、心因性非てんかん発作、不安障害、睡眠障害、失神が多かった。

 

脳血流検査:認知機能低下17例;辺縁系関連領域で有意な血流低下。FSIQは右半球内側前頭回・直回、VIQは右半球梁下回・直回・左半球視床、PIQは右半球内側前頭回血流低下。内側前頭野は感情コントロールや行動の抑制的統御に関与、血流低下→認知機能障害、情動と関連した症状

 

髄液検査:IL-4、IL-13が有意に高値、B細胞分化、抗体産生促進などのTh2シフト、NMDA型GluR等の神経分子に対する抗体が高値、髄液で産生。マウス海馬内にGlutに対する抗体を投与する実験で、HPV群の種々の中枢神経系関連症状に関与している可能性が明らかになった。

 

髄液IL-17濃度は神経症状発病後12~24カ月で高値、脊髄後角でのGluN1のリン酸化を促進し痛覚過敏に関与している可能性。髄液IL-8は有意に高値で経過中神経症状発病後10~30か月に高値、GluN2Bのリン酸化を促進し、痛覚過敏に関与。髄液MCP-1の増加も痛覚過敏に関与

 

症状のある多くの症例が髄液の免疫学的変化を主体とした生物学的変化を有していた。また、それらの生物学的変化は、症状を説明し得るものであった。丁寧な問診、適切な検査と専門医への紹介、患者の病態理解を援助し、将来への希望を失うことがないように、医療者は患者を支援していきたい。

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ツイッターから

2017-08-21 | 資料

12

今日届いた内科学会雑誌ですが、HPVワクチン接種後の中枢神経系関連症状について特集がありました。著作の関係で内容は言えませんが、内科の雑誌に掲載されていることに驚きました。他の特集も勉強になります。

https://pbs.twimg.com/media/DHuxg3XV0AAIVjl.jpg:large

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久住先生お勧めのフルミストで抗NMDA受容体脳炎となったケース

2017-08-13 | 資料

https://www.youtube.com/watch?v=Y2mk5RuP4bE

https://i.ytimg.com/vi/Y2mk5RuP4bE/maxresdefault.jpg

13歳の少女が、2014年3月にフルミストワクチンを接種して、抗NMDA受容体脳炎を発症し、1年後も副反応に苦しんでいるその様子を映したビデオです。

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久住先生お勧めのフルミストで脳炎とギランバレーとなったケース

2017-08-13 | 資料

https://www.youtube.com/watch?v=NnZsxouApTU

https://i.ytimg.com/vi/NnZsxouApTU/maxresdefault.jpg

Here is a short video of Jy after soccer practice. He also thought his teacher gave another kid preferential treatment, but he misunderstood. He is recovering from Bickerstaff Brainstem Encephalitis and Guillain-Barre Syndrome after receiving the flu mist.

Jy 君は、フルミストワクチンの後に、ビッカースタッフ型脳幹脳炎とギランバレー症候群を発症し、回復中ですが、情緒の問題があって、このビデオではサッカーの練習のあとに、先生が他の子をえこひいきしていると誤解して泣いている様子を映しています。

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タイからのHPV副反応のニュース 全く異なる2つのバージョン

2017-08-09 | 資料

バンコクポストのウェブページ

PHITSANULOK – Four Prathom 5 students were rushed to a hospital after they were given an HPV vaccination on Wednesday morning.(グレード5の生徒4人が、水曜日の午前中にHPVワクチンを接種した後、病院へ送られた)

Following the injection - said to help prevent the development of cervical cancer later in life - eleven girls developed tightness of the chest, palpitations and fatigue. (将来子宮頸がんの発症を予防する注射の後、11人の少女が胸苦しさ、動悸、疲労を訴えた。)

Medical personnel rushed to Ban Krang (Phra Khao Chaisit) School to give first-aid treatment, and four girls were sent to the hospital - one in a serious condition due to her chronic asthma. The girl was later reported to be recovering.  (救急車が呼ばれ、4人が病院に運ばれた。そのうちの一人は、慢性の喘息のため、重症である)

Charunee Nasorn, a senior nurse at Ban Krang health promotion centre, said the injection had been given to a total of 16 Prathom-5 students, 11 of whom developed symptoms.  She said that the centre had previously given the injection to students from another school with no adverse effects, and a doctor would need to investigate the cause of the symptoms. (看護師の証言:グレード5の生徒16人が注射を受け、そのうちの11人が症状を発症した。先に他の学校で注射をしたときは、副反応はなかった。症状の原因は医師により調査される必要がある)

Sasipa Phuthiladdawan, a teacher at the school, said the 16 students had received their parents’ consent to receive the vaccination voluntarily. (教師の証言:これらの生徒16人は、自発的にワクチンを接種するという両親の同意を受け取っている)

 

ネイションという新聞

Schoolgirls struck by mystery symptoms – even before being vaccinated

女生徒が、ワクチン接種前に、奇妙な症状を発症した

Around Thailand August 09, 2017 16:10

By Mongkolchaowarat Tangmangmee
The Nation

 

Sixteen Prathom 5 schoolgirls experienced chest tightness, palpitations and fainting while being vaccinated against human papilloma virus (HPV) at Ban Krang School in Phitsanulok’s Muang district on Wednesday.

水曜日に、HPVワクチンを接種している間、16人のグレード5の生徒が、胸苦しさ、動悸、失神をおこした。

Tambon Ban Krang Health Promotion Hospital nurse Jarunee Nasorn confirmed that 16 students had developed the symptoms - 11 of whom had yet to receive the vaccine. 

(看護師は、16人の生徒が症状を発症し、そのうち11人は、ワクチンをまだ接種していなかったと証言した。

Jarunee said her team had earlier vaccinated other students without any side effects or problems.

(看護師は、前に他の生徒にワクチンを接種したときは副作用や問題はなかったと言った)

Most of the students recovered after receiving first aid, although three were taken to two hospitals. One of the three was said to have suffered an asthma attack.

(応急処置をうけ、ほとんどの生徒は回復したが、3人は2つの病院に運ばれた。3人のうちの一人は、喘息の発作が起きた)

The government HPV vaccination project covers about 400,000 Prathom 5 schoolgirls nationwide.

Starting this month, the project is intended to prevent cervical cancer, the second most common cause of death by illness in Thai women. 

Thailand has about 6,000 new cases of cervical cancer reported each year and the death rate is about 3,000 a year.

Medical staff are investigating the causes of the girls’ symptoms.

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新薬を発売するまでの広告代理店の役割など

2017-08-07 | 資料

https://www.youtube.com/watch?v=DsDRQTDjQA8

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

新薬や新ワクチンの売り込みについて、元製薬会社の宣伝部長さんだった方が暴露しています。

裏で糸を曳いているのが広告代理店であり、ピアーレビューの医学誌に載せる論文を製薬会社の社員が書いていたりと

まるで日本での子宮頸がんワクチンのことのようで驚きます。

医師の中から宣伝隊長を選んで(今野先生)、

その下に子分をつける(久住先生、かるがも先生その他)など、よく説明してあります。

日本の推進派医師が踊らされている実情がよくわかると思います。

 

日本は孫分(Akimiさん)もいた!

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子宮頸がんワクチン接種世代で、HPVのタイプ・リプレイスメントが起こったという報告

2017-08-06 | 論文

https://www.spandidos-publications.com/ol/12/1/601

Shift in prevalence of HPV types in cervical cytology specimens in the era of HPV vaccination

ドイツからの報告

子宮頸部の細胞診で異常が見られた615人の女性のHPV型を調査

ワクチン接種世代とワクチン非接種世代に分けて考察

ワクチン接種世代では、ワクチンに含まれているHPV16と18は減少していたが、HPV51 (13.83%), HPV56 (10.00%), HPV66 (8.72%)が増加していた。

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