ガーダシルは雌マウスでうつ病を誘発する

また、ガーダシル接種マウスの血清中の抗体は、脳のタンパク質抽出物と反応する

海馬のCA1領域のミクログリアが活性化する

ガーダシルは脳の炎症および自己免疫反応を惹起し、行動に変化をもたらしている

 

サーバリックスを使用した池田班の実験と同じ結果？

ガーディアンの記事、イギリスで子宮頸がんワクチン接種世代の精神疾患急増とも関連か？

 

 

Immunol Res. 2017 Feb;65(1):136-149. doi: 10.1007/s12026-016-8826-6.

Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil.

Inbar R^1,2, Weiss R^3,4, Tomljenovic L^1,5, Arango MT^1,6, Deri Y¹, Shaw CA⁵, Chapman J^1,7, Blank M¹, Shoenfeld Y^8,9.

Author information

Abstract

Vaccine adjuvants and vaccines may induce autoimmune and inflammatory manifestations in susceptible individuals. To date most human vaccine trials utilize aluminum (Al) adjuvants as placebos despite much evidence showing that Al in vaccine-relevant exposures can be toxic to humans and animals. We sought to evaluate the effects of Al adjuvant and the HPV vaccine Gardasil versus the true placebo on behavioral and inflammatory parameters in female mice. Six-week-old C57BL/6 female mice were injected with either, Gardasil, Gardasil + pertussis toxin (Pt), Al hydroxide, or, vehicle control in amounts equivalent to human exposure. At 7.5 months of age, Gardasil and Al-injected mice spent significantly more time floating in the forced swimming test (FST) in comparison with vehicle-injected mice (Al, p = 0.009; Gardasil, p = 0.025; Gardasil + Pt, p = 0.005). The increase in floating time was already highly significant at 4.5 months of age for the Gardasil and Gardasil + Pt group (p ≤ 0.0001). No significant differences were observed in the number of stairs climbed in the staircase test which measures locomotor activity. These results indicate that differences observed in the FST were unlikely due to locomotor dysfunction, but rather due to depression. Moreover, anti-HPV antibodies from the sera of Gardasil and Gardasil + Pt-injected mice showed cross-reactivity with the mouse brain protein extract. Immunohistochemistry analysis revealed microglial activation in the CA1 area of the hippocampus of Gardasil-injected mice. It appears that Gardasil via its Al adjuvant and HPV antigens has the ability to trigger neuroinflammation and autoimmune reactions, further leading to behavioral changes.