接種部位での抗原さがし NMDA受容体

Biochemistry (Mosc). 2012 Feb;77(2):128-34. doi: 10.1134/S0006297912020022.

NMDA receptors in immune competent cells.

Boldyrev AA¹, Bryushkova EA, Vladychenskaya EA.

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Abstract

This review presents analysis of literature data indicating the presence of NMDA-type glutamate receptors in several types of immune competent cells such as thymocytes, lymphocytes, and neutrophils. The possible role of these receptors in the function of these cells is discussed. The interaction of the receptors with certain ligands circulating in the bloodstream and their role in modulation of immune function is described. It is suggested that homocysteine acts as modulator of these receptors, and its toxicity is largely explained by hyperactivation of the NMDA-type glutamate receptors.

 

（補足）

アラムアジュバント（アルミ）が好中球細胞外トラップNETを誘発するという石井先生による説明

http://www.ifrec.osaka-u.ac.jp/jpn/research/upload_img/Ken%20Ishii_Nat%20Medicine%20%E8%A7%A3%E8%AA%AC.pdf

 

左の図が好中球が細胞の中身をぶちまけている様子