文 献
1. Lemaitre B, Nicolas E, Michaut L, et al.: The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86:973-83, 1996
2. Akira S, Uematsu S, Takeuchi O: Pathogen recognition and innate immunity. Cell 124:783-801, 2006
3. Roach JC, Glusman G, Rowen L, et al.: The evolution of vertebrate Toll-like receptors. Proc Natl Acad Sci U S A 102:9577-82, 2005
4. Seo HS, Michalek SM, Nahm MH: Lipoteichoic acid is important in innate immune responses to gram-positive bacteria. Infect Immun 76:206-1, 2008
5. Poltorak A, He X, Smirnova I, et al.: Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085-8, 1998
6. Matsuda N, Hattori Y: Systemic inflammatory response syndrome (SIRS): Molecular pathophysiology and gene therapy. J Pharmacol Sci 101: 189-198, 2006
7. Ozinsky A, Underhill DM, Fontenot JD, et al.: The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci U S A 97:13766-71, 2000
8. Jin MS, Kim SE, Heo JY, et al.: Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130:1071-82, 2007
9. Mullick AE, Tobias PS, Curtiss LK: Modulation of atherosclerosis in mice by Toll-like receptor 2. J Clin Invest 115:3149-56, 2005
10. Buwitt-Beckmann U, Heine H, Wiesmüller KH, et al.: Toll-like receptor 6-independent signaling by diacylated lipopeptides. Eur J Immunol 35:282-9, 2005
11. Hayashi F, Smith KD, Ozinsky A, et al.: The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410:1099-103, 2001
12. Le Goffic R, Pothlichet J, Vitour D, et al.: Cutting Edge: Influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells. J Immunol 178:3368-72, 2007
13. Sakai A, Koga T, Lim JH, et al.: The bacterium, nontypeable Haemophilus influenzae, enhances host antiviral response by inducing Toll-like receptor 7 expression: evidence for negative regulation of host anti-viral response by CYLD. FEBS J 274:3655-68, 2007
14. Hammerbeck DM, Burleson GR, Schuller CJ, et al.: Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats. Antiviral Res 73:1-11, 2007
15. Knuefermann P, Baumgarten G, Koch A, et al.: CpG oligonucleotide activates Toll-like receptor 9 and causes lung inflammation in vivo. Respir Res 8:72, 2007
16. Roger T, David J, Glauser MP, et al.: MIF regulates innate immune responses through modulation of Toll-like receptor 4. Nature 414:920-4, 2001
17. Matsuda N, Nishihira J, Takahashi Y, et al.: Role of macrophage migration inhibitory factor in acute lung injury in mice with acute pancreatitis complicated by endotoxemia. Am J Respir Cell Mol Biol 35:198-205, 2006
18. Ohkawara T, Takeda H, Miyashita K, et al.: Regulation of Toll-like receptor 4 expression in mouse colon by macrophage migration inhibitory factor. Histochem Cell Biol 125:575-82, 2006
19. Matsuda N, Yamazaki H, Takano K, et al.: Priming by lipopolysaccharide exaggerates acute lung injury and mortality in responses to peptidoglycan through up-regulation of Toll-like receptor-2 expression in mice. Biochem Pharmacol 75:1065-1075, 2008
20. Matsuda N, Hayashi Y, Takahashi Y, et al.: Phosphorylation of endothelial nitric-oxide synthase is diminished in mesenteric arteries from septic rabbits depending on the altered phosphatidylinositol 3-kinase/Akt pathway: reversal effect of fluvastatin therapy. J Pharmacol Exp Ther 319:1348-54, 2006
21. Slack JL, Schooley K, Bonnert TP, et al.: Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways. J Biol Chem 275:4670-8, 2000
22. Wald D, Qin J, Zhao Z, et al.: SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol 4:920–7, 2003
23. Brint EK, Xu D, Liu H, et al.: ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat Immunol 5:373–9, 2004
24. Li S, Strelow A, Fontana EJ, et al.: IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc Natl Acad Sci U S A 99:5567-72, 2002
25. Kawai T, Takeuchi O, Fujita T, et al.: Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol 167:5887-94, 2001
26. Fitzgerald KA, Palsson-McDermott EM, Bowie AG, et al.: Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413:78-83, 2001
27. Kagan JC, Medzhitov R: Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell 125:943-55, 2006
28. Horng T, Barton GM, Flavell RA, et al.: The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature 420:329-33, 2002
29. Yamamoto M, Sato S, Hemmi H, et al.: TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol 4:1144-50, 2003
30. Yamamoto M, Sato S, Hemmi H, et al.: Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301:640-3, 2003
31. Jeyaseelan S, Young SK, Fessler MB, et al: Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumonia. J Immunol 178:3153-60, 2007
32. Han KJ, Su X, Xu LG, et al.: Mechanisms of the TRIF-induced interferon-stimulated response element and NF-B activation and apoptosis pathways. J Biol Chem 279:15652-61, 2004
33. Fitzgerald KA, McWhirter SM, Faia KL, et al.: IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 4:491-6, 2003
34. Shuang Chen, Wong MH, Schulte DJ, et al.: Differential expression of Toll-like receptor 2 (TLR2) and responses to TLR2 ligands between human and murine vascular endothelial cells. J Endotoxin Res 13:281-96, 2007
35. Talreja J, Kabir MH, B Filla M, et al.: Histamine induces Toll-like receptor 2 and 4 expression in endothelial cells and enhances sensitivity to Gram-positive and Gram-negative bacterial cell wall components. Immunology 113:224-33, 2004
36. Hijiya N, Miyake K, Akashi S, et al.: Possible involvement of toll-like receptor 4 in endothelial cell activation of larger vessels in response to lipopolysaccharide. Pathobiology 70:18-25, 2002
37. Miettinen M, Sareneva T, Julkunen I, et al.: IFNs activate toll-like receptor gene expression in viral infections. Genes Immun 2:349-55, 2001
38. Heidemann J, Rüther C, Kebschull M, et al.: Expression of IL-12-related molecules in human intestinal microvascular endothelial cells is regulated by TLR3. Am J Physiol Gastrointest Liver Physiol 293:G1315-24, 2007
39. Maaser C, Heidemann J, von Eiff C, et al.: .Human intestinal microvascular endothelial cells express Toll-like receptor 5: a binding partner for bacterial flagellin. J Immunol 172:5056-62, 2004
40. Bulut Y, Faure E, Thomas L, et al.: Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling. J Immunol 167:987-94, 2001
41. Gunzer M, Riemann H, Basoglu Y, et al.: Systemic administration of a TLR7 ligand leads to transient immune incompetence due to peripheral-blood leukocyte depletion. Blood 106:2424-32, 2005
42. Li J, Ma Z, Tang ZL, Stevens T, et al.: CpG DNA-mediated immune response in pulmonary endothelial cells. Am J Physiol Lung Cell Mol Physiol 287:L552-8, 2004
43. Tissari J, Sirén J, Meri S, et al.: IFN-α enhances TLR3-mediated antiviral cytokine expression in human endothelial and epithelial cells by up-regulating TLR3 expression. J Immunol 174:4289-94, 2005
44. Bannerman DD, Erwert RD, Winn RK, et al.: TIRAP mediates endotoxin-induced NF-B activation and apoptosis in endothelial cells. Biochem Biophys Res Commun 295:157-62, 2002
45. Harari OA, Alcaide P, Ahl D, et al.: Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway. Circ Res 98:1134-40, 2006
46. Kulms D, Schwarz T. NF-B and cytokines. Vitam Horm 74:283-300, 2006
47. Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol 4:E131-6, 2002
48. 松田直之, 山本誠士, 神山公希, 他： Surviving Sepsis Campaign guidlinesにおけるrelative adrenal insufficiencyの対策. 救急医学 1362-70, 2007
1. Lemaitre B, Nicolas E, Michaut L, et al.: The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86:973-83, 1996
2. Akira S, Uematsu S, Takeuchi O: Pathogen recognition and innate immunity. Cell 124:783-801, 2006
3. Roach JC, Glusman G, Rowen L, et al.: The evolution of vertebrate Toll-like receptors. Proc Natl Acad Sci U S A 102:9577-82, 2005
4. Seo HS, Michalek SM, Nahm MH: Lipoteichoic acid is important in innate immune responses to gram-positive bacteria. Infect Immun 76:206-1, 2008
5. Poltorak A, He X, Smirnova I, et al.: Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085-8, 1998
6. Matsuda N, Hattori Y: Systemic inflammatory response syndrome (SIRS): Molecular pathophysiology and gene therapy. J Pharmacol Sci 101: 189-198, 2006
7. Ozinsky A, Underhill DM, Fontenot JD, et al.: The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci U S A 97:13766-71, 2000
8. Jin MS, Kim SE, Heo JY, et al.: Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130:1071-82, 2007
9. Mullick AE, Tobias PS, Curtiss LK: Modulation of atherosclerosis in mice by Toll-like receptor 2. J Clin Invest 115:3149-56, 2005
10. Buwitt-Beckmann U, Heine H, Wiesmüller KH, et al.: Toll-like receptor 6-independent signaling by diacylated lipopeptides. Eur J Immunol 35:282-9, 2005
11. Hayashi F, Smith KD, Ozinsky A, et al.: The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410:1099-103, 2001
12. Le Goffic R, Pothlichet J, Vitour D, et al.: Cutting Edge: Influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells. J Immunol 178:3368-72, 2007
13. Sakai A, Koga T, Lim JH, et al.: The bacterium, nontypeable Haemophilus influenzae, enhances host antiviral response by inducing Toll-like receptor 7 expression: evidence for negative regulation of host anti-viral response by CYLD. FEBS J 274:3655-68, 2007
14. Hammerbeck DM, Burleson GR, Schuller CJ, et al.: Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats. Antiviral Res 73:1-11, 2007
15. Knuefermann P, Baumgarten G, Koch A, et al.: CpG oligonucleotide activates Toll-like receptor 9 and causes lung inflammation in vivo. Respir Res 8:72, 2007
16. Roger T, David J, Glauser MP, et al.: MIF regulates innate immune responses through modulation of Toll-like receptor 4. Nature 414:920-4, 2001
17. Matsuda N, Nishihira J, Takahashi Y, et al.: Role of macrophage migration inhibitory factor in acute lung injury in mice with acute pancreatitis complicated by endotoxemia. Am J Respir Cell Mol Biol 35:198-205, 2006
18. Ohkawara T, Takeda H, Miyashita K, et al.: Regulation of Toll-like receptor 4 expression in mouse colon by macrophage migration inhibitory factor. Histochem Cell Biol 125:575-82, 2006
19. Matsuda N, Yamazaki H, Takano K, et al.: Priming by lipopolysaccharide exaggerates acute lung injury and mortality in responses to peptidoglycan through up-regulation of Toll-like receptor-2 expression in mice. Biochem Pharmacol 75:1065-1075, 2008
20. Matsuda N, Hayashi Y, Takahashi Y, et al.: Phosphorylation of endothelial nitric-oxide synthase is diminished in mesenteric arteries from septic rabbits depending on the altered phosphatidylinositol 3-kinase/Akt pathway: reversal effect of fluvastatin therapy. J Pharmacol Exp Ther 319:1348-54, 2006
21. Slack JL, Schooley K, Bonnert TP, et al.: Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways. J Biol Chem 275:4670-8, 2000
22. Wald D, Qin J, Zhao Z, et al.: SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol 4:920–7, 2003
23. Brint EK, Xu D, Liu H, et al.: ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat Immunol 5:373–9, 2004
24. Li S, Strelow A, Fontana EJ, et al.: IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc Natl Acad Sci U S A 99:5567-72, 2002
25. Kawai T, Takeuchi O, Fujita T, et al.: Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol 167:5887-94, 2001
26. Fitzgerald KA, Palsson-McDermott EM, Bowie AG, et al.: Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413:78-83, 2001
27. Kagan JC, Medzhitov R: Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell 125:943-55, 2006
28. Horng T, Barton GM, Flavell RA, et al.: The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature 420:329-33, 2002
29. Yamamoto M, Sato S, Hemmi H, et al.: TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol 4:1144-50, 2003
30. Yamamoto M, Sato S, Hemmi H, et al.: Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301:640-3, 2003
31. Jeyaseelan S, Young SK, Fessler MB, et al: Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumonia. J Immunol 178:3153-60, 2007
32. Han KJ, Su X, Xu LG, et al.: Mechanisms of the TRIF-induced interferon-stimulated response element and NF-B activation and apoptosis pathways. J Biol Chem 279:15652-61, 2004
33. Fitzgerald KA, McWhirter SM, Faia KL, et al.: IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 4:491-6, 2003
34. Shuang Chen, Wong MH, Schulte DJ, et al.: Differential expression of Toll-like receptor 2 (TLR2) and responses to TLR2 ligands between human and murine vascular endothelial cells. J Endotoxin Res 13:281-96, 2007
35. Talreja J, Kabir MH, B Filla M, et al.: Histamine induces Toll-like receptor 2 and 4 expression in endothelial cells and enhances sensitivity to Gram-positive and Gram-negative bacterial cell wall components. Immunology 113:224-33, 2004
36. Hijiya N, Miyake K, Akashi S, et al.: Possible involvement of toll-like receptor 4 in endothelial cell activation of larger vessels in response to lipopolysaccharide. Pathobiology 70:18-25, 2002
37. Miettinen M, Sareneva T, Julkunen I, et al.: IFNs activate toll-like receptor gene expression in viral infections. Genes Immun 2:349-55, 2001
38. Heidemann J, Rüther C, Kebschull M, et al.: Expression of IL-12-related molecules in human intestinal microvascular endothelial cells is regulated by TLR3. Am J Physiol Gastrointest Liver Physiol 293:G1315-24, 2007
39. Maaser C, Heidemann J, von Eiff C, et al.: .Human intestinal microvascular endothelial cells express Toll-like receptor 5: a binding partner for bacterial flagellin. J Immunol 172:5056-62, 2004
40. Bulut Y, Faure E, Thomas L, et al.: Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling. J Immunol 167:987-94, 2001
41. Gunzer M, Riemann H, Basoglu Y, et al.: Systemic administration of a TLR7 ligand leads to transient immune incompetence due to peripheral-blood leukocyte depletion. Blood 106:2424-32, 2005
42. Li J, Ma Z, Tang ZL, Stevens T, et al.: CpG DNA-mediated immune response in pulmonary endothelial cells. Am J Physiol Lung Cell Mol Physiol 287:L552-8, 2004
43. Tissari J, Sirén J, Meri S, et al.: IFN-α enhances TLR3-mediated antiviral cytokine expression in human endothelial and epithelial cells by up-regulating TLR3 expression. J Immunol 174:4289-94, 2005
44. Bannerman DD, Erwert RD, Winn RK, et al.: TIRAP mediates endotoxin-induced NF-B activation and apoptosis in endothelial cells. Biochem Biophys Res Commun 295:157-62, 2002
45. Harari OA, Alcaide P, Ahl D, et al.: Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway. Circ Res 98:1134-40, 2006
46. Kulms D, Schwarz T. NF-B and cytokines. Vitam Horm 74:283-300, 2006
47. Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol 4:E131-6, 2002
48. 松田直之, 山本誠士, 神山公希, 他： Surviving Sepsis Campaign guidlinesにおけるrelative adrenal insufficiencyの対策. 救急医学 1362-70, 2007
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