FLIP Nature Reviews Immunology 6, 196-204, 2006

cFLIP regulation of lymphocyte activation and development

Ralph C. Budd1, Wen-Chen Yeh2 and Jürg Tschopp3 About the authors

Cellular caspase-8 (FLICE)-like inhibitory protein (cFLIP) was originally identified as an inhibitor of death-receptor signalling through competition with caspase-8 for recruitment to FAS-associated via death domain (FADD). More recently, it has been determined that both cFLIP and caspase-8 are required for the survival and proliferation of T cells following T-cell-receptor stimulation. This paradoxical finding launched new investigations of how these molecules might connect with signalling pathways that link to cell survival and growth following antigen-receptor activation. As discussed in this Review, insight gained from these studies indicates that cFLIP and caspase-8 form a heterodimer that ultimately links T-cell-receptor signalling to activation of nuclear factor-B through a complex that includes B-cell lymphoma 10 (BCL-10), mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1 (MALT1) and receptor-interacting protein 1 (RIP1).

FLIPは炎症細胞がアポトーシスを起こさないためのkeyとなる蛋白です。主要臓器の炎症病態のFLIPの解析に取り掛かります。