Breakthrough invasive Candida glabrata in patients on micafungin: A novel FKS gene conversion correlated with sequential elevation of minimum inhibitory concentration.
J Clin Microbiol. 2014 Apr 30. [Epub ahead of print]
Saraya T1, Tanabe K, Araki K, Yonetani S, Makino H, Watanabe T, Tsujimoto N, Takata S, Kurai D, Ishii H, Miyazaki Y, Takizawa H, Goto H.
Abstract
The Candida glabrata strains sequentially isolated from blood developed micafungin-resistance from <0.015 to 4 μg/mL of minimum inhibitory concentrations.
A novel mutation, 262 bp of FKS2 (containing F659del) was converted to the homologous region in FKS1, was identified in micafungin-resistant strains.
PMID: 24789192
