杏林大学呼吸器内科　『あんずの呼吸 part2』

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Epidemiology of virus-induced asthma exacerbations with special reference to the role of HRV

2014年05月28日 | 医局のソファー
REVIEW ARTICLE Front. Microbiol., 26 May 2014 | doi: 10.3389/fmicb.2014.00226

Epidemiology of virus-induced asthma exacerbations: with special reference to the role of human rhinovirus
Takeshi Saraya1, Daisuke Kurai1, Haruyuki Ishii1, Anri Ito1, Yoshiko Sasaki2, Shoichi Niwa2, Naoko Kiyota3, Hiroyuki Tsukagoshi2, Kunihisa Kozawa2, Hajime Goto1 and Hajime Takizawa1*

1Department of Respiratory Medicine, School of Medicine, Kyorin University, Mitaka, Tokyo, Japan

2Gunma Prefectural Institute of Public Health and Environmental Sciences, Gunma, Japan

3Kumamoto Prefectural Institute of Public Health and Environmental Sciences, Kumamoto, Japan

Viral respiratory infections may be associated with the virus-induced asthma in adults as well as children.
Particularly, human rhinovirus is strongly suggested a major candidate for the associations of the virus-induced asthma.
Thus, in this review, we reviewed and focused on the epidemiology, pathophysiology, and treatment of virus-induced asthma with special reference on human rhinovirus.
Furthermore, we added our preliminary data regarding the clinical and virological findings in the present review.

Mechanic's hands 機械工の手

2014年05月18日 | 医局のソファー

Research article

Mechanic's hands revisited: is this sign still useful for diagnosis in patients with lung involvement of collagen vascular diseases?

Erei Sohara, Takeshi Saraya, Shinji Sato, Naoki Tsujimoto,
Takayasu Watanabe, Saori Takata, Yasutaka Tanaka, Haruyuki Ishii,
Hajime Takizawa and Hajime Goto

BMC Research Notes 2014, 7:303 doi:10.1186/1756-0500-7-303

Background
The presence of "mechanic's hands" is one of the clinical clues for collagen vascular diseases.
However, the exact relevance of "mechanic's hands" in collagen vascular diseases has not been well documented.
The aim of this study was to clarify the relevance of "mechanic's hands" to collagen vascular diseases
including various skin lesions and interstitial pneumonia.

Methods
A retrospective review of the medical records of patients with "mechanic's hands" at our hospital
between April 2011 and December 2012 was conducted. A PubMed search was also conducted using the term "mechanic's hands".

Results
Four patients in our institution and 40 patients obtained from PubMed who had "mechanic's hands" were identified.
The most frequent diseases were DM/amyopathic DM (n = 24, 54.5%) and anti-ARS syndrome (n = 17, 38.6%). In these patients,
the major skin lesions associated with "mechanic's hands" were periungual erythema (n = 23, 52.3%),
Gottron's sign (n = 17, 38.6%), heliotrope rash (n = 10, 22.7%), Raynaud's phenomenon (n = 9, 20.5%),
and anti-ARS syndrome (n = 17, 38.6%). Six cases (2 DM, 4 anti-ARS syndrome) had only "mechanic's hands".
Antibodies to anti-ARS (n = 24) were Jo-1 (n = 19), PL-7 (n = 3), OJ (n = 1), and PL-12 (n = 1).

Conclusion
The presence of "mechanic's hands" together with diverse skin lesions could be a clinical clue to the diagnosis of
lung involvement associated with collagen vascular diseases, especially in anti-ARS syndrome or DM/amyopathic DM.

Breakthrough invasive Candida glabrata in patients on micafungin: A novel FKS gene conversion

2014年05月11日 | 医局のソファー


Breakthrough invasive Candida glabrata in patients on micafungin: A novel FKS gene conversion correlated with sequential elevation of minimum inhibitory concentration.

J Clin Microbiol. 2014 Apr 30. [Epub ahead of print]

Saraya T1, Tanabe K, Araki K, Yonetani S, Makino H, Watanabe T, Tsujimoto N, Takata S, Kurai D, Ishii H, Miyazaki Y, Takizawa H, Goto H.

Abstract
The Candida glabrata strains sequentially isolated from blood developed micafungin-resistance from <0.015 to 4 μg/mL of minimum inhibitory concentrations.
A novel mutation, 262 bp of FKS2 (containing F659del) was converted to the homologous region in FKS1, was identified in micafungin-resistant strains.
PMID: 24789192