【論】Ideker,2000,Testing for Differentially-Express～

Trey Ideker, Vesteinn Thorsson, Andrew F. Siegel and Leroy E. Hood
Testing for Differentially-Expressed Genes by Maximum-Likelihood Analysis of DNA Microarray Data.
Journal of Computational Biology 7: 805-817 (2000).
[PDF][Web Site]

・Maximum-likelihood analysis を応用した遺伝子抽出法の提案。
・データ：Yeast、約6200遺伝子、cDNA

・方法「Here, we report a refined test for differentially expressed genes which does not rely on gene expression ratios but directly compares a series of repeated measurements of the two dye intensities for each gene.」
・結果「However, due to the large number of genes involved in a typical experiment, we have demonstrated that a likelihood ratio test performed with only four samples per gene chooses differentially-expressed gene candidates that are in good agreement with other experimental evidence.」

・やたらと読み取りづらく、内容がさっぱりわからない。