「ペルー沖中国人船員ナゾの死亡事件」続報

ペルー沖の中国船で中国人船員２名がナゾの死を遂げ、「すわ、新型インフルエンザか！？」とペルー当局が色めきかけた件の続報です。
http://blog.goo.ne.jp/tabibito12/d/20080423（新型インフルエンザより怖いかもしれない話）
http://blog.goo.ne.jp/tabibito12/d/20080421 （ペルー沖で中国人船員ナゾのウイルスに死す）

新型／鳥インフルエンザは否定され、アデノウイルスらしいというところまでは前回のニュースでした。
細菌培養では特に突然変異株は見つからず。死亡した船員にマウスツーマウスで救命処置をおこなった関係者には同症状見当たらず。検疫も解除。

死亡した２名の解剖結果は、肺浮腫・脳浮腫の所見、また、組織所見（臓器をちょこっとプレパラートにとって顕微鏡で見た所見）では毒素(toxin）の所見。

つまり、がつくった”毒素”にやられた・・最近話題になったものではｏ－１５７に近い構造みたいです。

同乗の船員はペルー当局者に感染者は出ておらず、とりあえず”新型インフルエンザより怖い話”にはならないようでほっとします

ソースは４月23日付ＰｒｏＭｅｄ↓
Date: Mon, 5 May 2008 19:31:54 -0400 (EDT)
From: ProMED-mail <promed@promed.isid.harvard.edu>
Subject: PRO/EDR> Undiagnosed deaths, Chinese fishermen - Peru (03): toxin susp.

UNDIAGNOSED DEATHS, CHINESE FISHERMEN - PERU (03): TOXIN SUSPECTED
******************************************************************
A ProMED-mail post
<http://www.promedmail.org>
ProMED-mail is a program of the
International Society for Infectious Diseases <http://www.isid.org>

Date: Mon 5 May 2008
From: Cesar Carcamo <carcamo@u.washington.edu

Peruvian National Institute of Health (INS): quarantine lifted
- --------------------------------------------------------------
Members of the Chang An 168's crew and the Peruvian personnel in contact with them are in good health, and local health authorities therefore lifted the quarantine on [22 Apr 2008].

According to the ship's captain, the only symptom in the 2 fatal cases on board of the ship was fever, 5 and 2 hours (respectively) prior to death, but the language barrier has precluded a more detailed investigation.  [Poor excuse: there is a Chinese restaurant in every major city worldwide! - Mod.JW]

Immunofluorescence showed evidence of adenovirus infection in the 2 cases and in 6 other crewmembers. No evidence of other respiratory viruses has been found. Cultures for adenovirus are being processed at this time, but there is still no evidence of a "mutant" strain.
Tests for leptospirosis were negative in all crewmembers. Upon contact with Peruvian health personnel, 15 of the fishermen had mild respiratory symptoms, but none had fever. No evidence of adenovirus or respiratory symptoms has been found on a crewmember that provided mouth-to-mouth breathing to one of the victims.

Autopsies on the fatal cases showed evidence of pneumonia and cerebral edema. Histopathology revealed evidence of a toxic process, although samples from the corpses were negative to 12 toxins evaluated.

The ship set sail from Yan Tai on 19 Aug 2007 and has remained at sea since. The Chang An 168 remained quarantined since 15 Mar 2008, when it delivered its cargo to the (mother ship) Dong Fen in international waters.

***Investigators interested in collaborating with the toxicological studies can contact Dr Patricia Garcia, Chief of the Peruvian National Institute of Health at <pgarciaf@ins.gob.pe>

- --
Cesar Carcamo, MD, MPH, PhD
Universidad Peruana Cayetano Heredia
Lima, Peru