# いい感じでまとめてます
# いよいよ、実際の土壌サンプルを調べるのか…
Weidong Zhu, Ichiro Shiojima, Yuzuru Ito, Zhi Li, Hiroyuki Ikeda, Masashi Yoshida, Atsuhiko T. Naito, Jun-ichiro Nishi, Hiroo Ueno, Akihiro Umezawa, Tohru Minamino, Toshio Nagai, Akira Kikuchi, Makoto Asashima, Issei Komuro.
Nature, Advance online | doi:10.1038/nature07027
Insulin-like growth-factor-binding proteins (IGFBPs) bind to and modulate the actions of insulin-like growth factors (IGFs). Although some of the actions of IGFBPs have been reported to be independent of IGFs, the precise mechanisms of IGF-independent actions of IGFBPs are largely unknown. Here we report a previously unknown function for IGFBP-4 as a cardiogenic growth factor. IGFBP-4 enhanced cardiomyocyte differentiation in vitro, and knockdown of Igfbp4 attenuated cardiomyogenesis both in vitro and in vivo. The cardiogenic effect of IGFBP-4 was independent of its IGF-binding activity but was mediated by the inhibitory effect on canonical Wnt signalling. IGFBP-4 physically interacted with a Wnt receptor, Frizzled 8 (Frz8), and a Wnt co-receptor, low-density lipoprotein receptor-related protein 6 (LRP6), and inhibited the binding of Wnt3A to Frz8 and LRP6. Although IGF-independent, the cardiogenic effect of IGFBP-4 was attenuated by IGFs through IGFBP-4 sequestration. IGFBP-4 is therefore an inhibitor of the canonical Wnt signalling required for cardiogenesis and provides a molecular link between IGF signalling and Wnt signalling.# IGFBP-4がIGFではなくてFrz8やLRP6に相互作用してWnt3Aがそれぞれに結合するのを阻害するんだそうな
# 行き着く先はMATRIXの世界…
# 確かに、これを食用作物の育たないところに栽培すれば現状の食用作物原料バイオエタノールの問題は解決されるが、それがずっと不適耕地だけに限定されている保証はない…
# 原子爆弾後障害研究会で発表だそうです
# 被爆後60年を経ても消えない核兵器の恐怖…
# 余っちゃいないだろう…この国はせっかく育て上げた博士を海外に供給するために日夜努力しているんだろうから…
Martha S. Windrem, Steven J. Schanz, Min Guo, Guo-Feng Tian, Vaughn Washco, Nancy Stanwood, Matthew Rasband, Neeta S. Roy, Maiken Nedergaard, Leif A. Havton, Su Wang, Steven A. Goldman.
Cell Stem Cell 2, 553-565 (2008) | DOI:10.1016/j.stem.2008.03.020
Congenitally hypomyelinated shiverer mice fail to generate compact myelin and die by 18–21 weeks of age. Using multifocal anterior and posterior fossa delivery of sorted fetal human glial progenitor cells into neonatal shiverer × rag2－/－ mice, we achieved whole neuraxis myelination of the engrafted hosts, which in a significant fraction of cases rescued this otherwise lethal phenotype. The transplanted mice exhibited greatly prolonged survival with progressive resolution of their neurological deficits. Substantial myelination in multiple regions was accompanied by the acquisition of normal nodes of Ranvier and transcallosal conduction velocities, ultrastructurally normal and complete myelination of most axons, and a restoration of a substantially normal neurological phenotype. Notably, the resultant mice were cerebral chimeras, with murine gray matter but a predominantly human white matter glial composition. These data demonstrate that the neonatal transplantation of human glial progenitor cells can effectively treat disorders of congenital and perinatal hypomyelination.# 新生児のまだ免疫が不完全なうちなら幹細胞の応用もしやすいのかもしれんなぁ
# 未だかつてこれほどまでに泳ぎに影響を及ぼしたスイムスーツは記憶にない…
# 先を越されましたな、ペタコン…
。さすがに箸一膳に10,000円も払うほど家系に余裕があるわけもないし、イマイチだなぁと思いつつ、近くのイトーヨーカドーやらイオンやらに足を運んで、それらしいものを物色するもイマイチ…
。愛用しているamazon.co.jpにもきちんと売っているではありませんか
。んでもって、その中からよさげなものを物色しまして、ちょっとだけ贅沢をしてお高めのものをチョイス。序でにおされな箸袋も一緒に購入したわけです。昨今のamazon.co.jpは以前にも増して対応が素早くなっておりまして、何たらいうオプションをつけなくてもかなりお早めに届きますので、発注翌日である昨日には到着しておった次第です。
