 | Wiiフィット(「バランスWiiボード」同梱) 任天堂 このアイテムの詳細を見る |
。これも普段の運動不足の賜です。一応、筋トレと有酸素運動を中心にこなしていますが、ヨガもいいらしいので、多少は取り入れようかと思案中…。。あと、「燃焼フラフープ」で673回まわしたのも私です
。それから、「ジョギング」の長距離で燃焼率180%なのも私です
。
SGT1 (for suppressor of G2 allele of skp1) and RAR1 (for required for Mla12 resistance) are highly conserved eukaryotic proteins that interact with the molecular chaperone HSP90 (for heat shock protein90). In plants, SGT1, RAR1, and HSP90 are essential for disease resistance triggered by a number of resistance (R) proteins. Here, we present structural and functional characterization of plant SGT1 proteins. Random mutagenesis of Arabidopsis thaliana SGT1b revealed that its CS (for CHORD-SGT1) and SGS (for SGT1 specific) domains are essential for disease resistance. NMR-based interaction surface mapping and mutational analyses of the CS domain showed that the CHORD II domain of RAR1 and the N-terminal domain of HSP90 interact with opposite sides of the CS domain. Functional analysis of the CS mutations indicated that the interaction between SGT1 and HSP90 is required for the accumulation of Rx, a potato (Solanum tuberosum) R protein. Biochemical reconstitution experiments suggest that RAR1 may function to enhance the SGT1–HSP90 interaction by promoting ternary complex formation.# 動植物共通免疫システム…そんなのがあるんだ…
DNA methyltransferase (cytosine-5) 1 (Dnmt1) is the principal enzyme responsible for maintenance of CpG methylation and is essential for the regulation of gene expression, silencing of parasitic DNA elements, genomic imprinting and embryogenesis. Dnmt1 is needed in S phase to methylate newly replicated CpGs occurring opposite methylated ones on the mother strand of the DNA, which is essential for the epigenetic inheritance of methylation patterns in the genome. Despite an intrinsic affinity of Dnmt1 for such hemi-methylated DNA, the molecular mechanisms that ensure the correct loading of Dnmt1 onto newly replicated DNA in vivo are not understood. The Np95 (also known as Uhrf1 and ICBP90) protein binds methylated CpG through its SET and RING finger-associated (SRA) domain. Here we show that localization of mouse Np95 to replicating heterochromatin is dependent on the presence of hemi-methylated DNA. Np95 forms complexes with Dnmt1 and mediates the loading of Dnmt1 to replicating heterochromatic regions. By using Np95-deficient embryonic stem cells and embryos, we show that Np95 is essential in vivo to maintain global and local DNA methylation and to repress transcription of retrotransposons and imprinted genes. The link between hemi-methylated DNA, Np95 and Dnmt1 thus establishes key steps of the mechanism for epigenetic inheritance of DNA methylation.# DNAの新生鎖に親鎖のメチル化をコピーする機構だそうな
…今年は受けておこうかしらChimpanzee memory has been extensively studied. The general assumption is that, as with many other cognitive functions, it is inferior to that of humans; some data, however, suggest that, in some circumstances, chimpanzee memory may indeed be superior to human memory. Here we report that young chimpanzees have an extraordinary working memory capability for numerical recollection ― better even than that of human adults tested in the same apparatus following the same procedure.# 「新しい能力を身につけるために古い能力を捨てる必要」…単に、そこまでの能力が不要になった、という解釈でダメなの？
