# 例え赤ワインといえども、毎日飲むのはよろしくないようです
Yukitoshi Izumi, Kazuhiro Tokuda, Kazuko A. O'Dell, Charles F. Zorumski, Toshio Narahashi.
Neuroscience Letters 426, 54-58 (2007) | doi:10.1016/j.neulet.2007.08.054
Oseltamivir (Tamiflu) is now being stockpiled by several governments as a first line treatment for an anticipated outbreak of avian influenza caused by H5N1. However, abnormal behaviors and death associated with the use of Tamiflu have developed into a major issue in Japan where Tamiflu is often prescribed for seasonal influenza. Thus, it is critical to determine neuropsychiatric effects of oseltamivir and to establish methods for safe administration. Using juvenile rats and rat hippocampal slices, we investigated whether oseltamivir has adverse effects on the central nervous system. Systemic injection of oseltamivir (50 mg/kg i.p.) produced no change in behavior within 2 h. However, prior injection of oseltamivir significantly altered the duration of loss of lightning reflex following ethanol injection (3.3 g/kg, i.p.). Ethanol injection in the presence of oseltamivir also resulted in enhanced hypothermia. In the CA1 region of hippocampal slices, oseltamivir (100 μM) induced paired-pulse facilitation in population spikes without changes in excitatory postsynaptic potentials. Similarly, 3 μM oseltamivir carboxylate, the active metabolite of oseltamivir, facilitated neuronal firing, though the facilitation did not involve GABAergic disinhibition. Moreover, oseltamivir carboxylate produced further facilitation following administration of 60 mM ethanol. These findings indicate that oseltamivir has effects on the central nervous system, especially when combined with other agents.# やはり脳関門突破の仕組みがキーになりますな
# 順調なようで何よりです
# 思うに、全原発の地震計を「公式地震計」として扱って地震情報に加えるべきでは？
James E. Lovelock, Chris G. Rapley.
Nature 449, 403 (2007) | doi:10.1038/449403a
# 自然の回復能力を引き出すのが最も適切な対応なのかも知れません
# ふう…やれやれ…これが長期傾向ではなく短期周期的な極小値であることを祈ります
# やっぱPCRかな？どのくらい簡単なんだろう？
# 利用者はシステムの性格をきちんと理解すべきです
D. R. Lorimer, M. Bailes, M. A. McLaughlin, D. J. Narkevic, F. Crawford.
Science, Science Express | DOI: 10.1126/science.1147532
Pulsar surveys offer one of the few opportunities to monitor even a small fraction (~10-5) of the radio sky for impulsive burst-like events with millisecond durations. In analysis of archival survey data, we have discovered a 30-Jy dispersed burst of duration <5 ms located three degrees from the Small Magellanic Cloud. The burst properties argue against a physical association with our Galaxy or the Small Magellanic Cloud. Current models for the free electron content in the Universe imply the burst is <1 Gpc distant. No further bursts are seen in 90-hr of additional observations, implying that it was a singular event such as a supernova or coalescence of relativistic objects. Hundreds of similar events could occur every day and act as insightful cosmological probes.# 科学は最新のデータじゃないと出来ないものではないことを示してくれているようです
# 実は、自分の遺伝情報が漏洩した場合に起きる本当の脅威については誰も知らないといっても過言ではないと思う
# はたして、脳から直接入力することが最善なのだろうか？
