# 昔、ちょっとかじっていたもので、つい…
# 妊娠三ヶ月時点での喫煙か…妊娠自覚してから禁煙しても遅いかも…
Ho Bum Park, Chul Ho Jung, Young Moo Lee, Anita J. Hill, Steven J. Pas, Stephen T. Mudie, Elizabeth Van Wagner, Benny D. Freeman, David J. Cookson.
Science 318, 254-258 (2007) | DOI: 10.1126/science.1146744
Within a polymer film, free-volume elements such as pores and channels typically have a wide range of sizes and topologies. This broad range of free-volume element sizes compromises a polymer's ability to perform molecular separations. We demonstrated free-volume structures in dense vitreous polymers that enable outstanding molecular and ionic transport and separation performance that surpasses the limits of conventional polymers. The unusual microstructure in these materials can be systematically tailored by thermally driven segment rearrangement. Free-volume topologies can be tailored by controlling the degree of rearrangement, flexibility of the original chain, and judicious inclusion of small templating molecules. This rational tailoring of free-volume element architecture provides a route for preparing high-performance polymers for molecular-scale separations.# 二酸化炭素レベルの分子とメタンレベルの分子を分子量の差で分画できるスポンジ…
# なんか動機が不純なんだよね、中国
# 凄いじゃないですか！あとは的中実績がいかほどか…
# 血液脳関門をどう突破するかが問題になっているんじゃなかったっけ？
# さて、個人レベルでは作られているというウワサの核融合炉、実用化できるんでしょうか
Masanori Miyanishi, Kazutoshi Tada, Masato Koike, Yasuo Uchiyama, Toshio Kitamura, Shigekazu Nagata.
Nature, Advance online publication | doi:10.1038/nature06307
In programmed cell death, a large number of cells undergo apoptosis, and are engulfed by macrophages to avoid the release of noxious materials from the dying cells. In definitive erythropoiesis, nuclei are expelled from erythroid precursor cells and are engulfed by macrophages. Phosphatidylserine is exposed on the surface of apoptotic cells and on the nuclei expelled from erythroid precursor cells; it works as an 'eat me' signal for phagocytes. Phosphatidylserine is also expressed on the surface of exosomes involved in intercellular signalling. Here we established a library of hamster monoclonal antibodies against mouse peritoneal macrophages, and found an antibody that strongly inhibited the phosphatidylserine-dependent engulfment of apoptotic cells. The antigen recognized by the antibody was identified by expression cloning as a type I transmembrane protein called Tim4 (T-cell immunoglobulin- and mucin-domain-containing molecule; also known as Timd4). Tim4 was expressed in Mac1+ cells in various mouse tissues, including spleen, lymph nodes and fetal liver. Tim4 bound apoptotic cells by recognizing phosphatidylserine via its immunoglobulin domain. The expression of Tim4 in fibroblasts enhanced their ability to engulf apoptotic cells. When the anti-Tim4 monoclonal antibody was administered into mice, the engulfment of apoptotic cells by thymic macrophages was significantly blocked, and the mice developed autoantibodies. Among the other Tim family members, Tim1, but neither Tim2 nor Tim3, specifically bound phosphatidylserine. Tim1- or Tim4-expressing Ba/F3 B cells were bound by exosomes via phosphatidylserine, and exosomes stimulated the interaction between Tim1 and Tim4. These results indicate that Tim4 and Tim1 are phosphatidylserine receptors for the engulfment of apoptotic cells, and may also be involved in intercellular signalling in which exosomes are involved.# スクラップ対象を見分けるタンパク質ですか
# 「宇宙エレベーター」…そんなことが可能なのかいまいち疑問…
# 医学誌最新号
…パーキンソン病患者にニコレットやニコチンパッチってのもありですか？Chris Rutherglen, Peter Burke.
Nano Lett., ASAP Article | doi:10.1021/nl0714839
Here we report experimental results for a carbon nanotube (CNT) based amplitude-modulated (AM) demodulator for modulation frequencies up to 100 kHz. Further, the CNT based demodulator was successfully demonstrated in an actual AM radio receiver operating at a carrier frequency of 1 GHz and capable of demodulating high-fidelity audio. The demodulation originates from the nonlinear current-voltage (IDS vs VDS) characteristic of the CNT, which induces rectification of a portion of the applied RF signal. By properly biasing the CNT such that the operating point is centered on the maximum nonlinear portion of the I-V curve, one can maximize the demodulation effect. This represents a simple application of carbon nanotubes and nanotechnology to the wireless realm.# 「アメリカ化学会に掲載する研究報告書」…一応、論文なんですけど…
# 自立的に動けばまさしくマイクロロボット…けど、カテーテルよりいい点ってなんだ？
