# ありゃま…何とか復旧してください
# 研究室火災については最終的な出火原因を是非とも公表して欲しい
# なんでH鎖フェリチンが増えるとアポトーシスが抑制されるんだ？
# これもレアメタル代替化学の一つですね
# カビにクロラムフェニコールが効くんだ…けど、すぐにCATをもったカビが蔓延しそう…
# うちの坊主達のも脳トレを毎日やらせてみるかな
Kazuo Tanaka, Kazuki Tainaka, Tadashi Umemoto, Akiko Nomura, Akimitsu Okamoto.
J. Am. Chem. Soc., ASAP Article | doi:10.1021/ja076140r
Nucleic acids often acquire new functions by forming a variety of complexes with metal ions. Osmium, in an oxidized state, also reacts with C5-methylated pyrimidines. However, control of the sequence specificity of osmium complexation with DNA is still immature, and the value of the resulting complexes is unknown. We have designed a bipyridine-attached adenine derivative for sequence-specific osmium complexation. Sequence-specific osmium complexation was achieved by hybridization of a short DNA molecule containing this functional nucleotide to a target DNA sequence and resulted in the formation of a cross-linked structure. The interstrand cross-link clearly distinguished methylated cytosines from unmethylated cytosines and was used to quantify the degree of methylation at a specific cytosine in the genome.# さすが岡本先生のラボ…
Farshad A. Mansouri, Mark J. Buckley, Keiji Tanaka.
Science, Science Express | DOI: 10.1126/science.1146384
Our cognitive abilities in performing tasks are influenced by experienced competition/conflict between behavioral choices. To determine the role of anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC) in conflict detection/resolution process, we conducted complementary lesion and single-cell recording studies in monkeys resolving a conflict between two rules. We observed conflict-induced behavioral adjustment that persisted after lesions within ACC, but disappeared following lesions within DLPFC. Activity in some cells within DLPFC was modulated by the current conflict level and in other cells by the conflict experienced in previous trial. These results show that DLPFC, but not ACC, is essential for the conflict-induced behavioral adjustment and suggest that encoding and maintenance of information about experienced conflict is mediated by DLPFC.# まず「迷う」という思考が何なのかを理解しないと…
# 重イオンビームを当てるとどの位の確率で新しい形質を示すんでしょう？
