Julie C. Lauterborn, Christopher S. Rex, Eniko Kramár, Lulu Y. Chen, Vijay Pandyarajan, Gary Lynch, Christine M. Gall.
The Journal of Neuroscience 27, 10685-10694 (2007) | doi:10.1523/JNEUROSCI.2624-07.2007
Mice lacking expression of the fragile X mental retardation 1 (Fmr1) gene have deficits in types of learning that are dependent on the hippocampus. Here, we report that long-term potentiation (LTP) elicited by threshold levels of theta burst afferent stimulation (TBS) is severely impaired in hippocampal field CA1 of young adult Fmr1 knock-out mice. The deficit was not associated with changes in postsynaptic responses to TBS, NMDA receptor activation, or levels of punctate glutamic acid decarboxylase-65/67 immunoreactivity. TBS-induced actin polymerization within dendritic spines was also normal. The LTP impairment was evident within 5 min of induction and, thus, may not be secondary to defects in activity-initiated protein synthesis. Protein levels for both brain-derived neurotrophic factor (BDNF), a neurotrophin that activates pathways involved in spine cytoskeletal reorganization, and its TrkB receptor were comparable between genotypes. BDNF infusion had no effect on baseline transmission or on postsynaptic responses to theta burst stimulation, but nonetheless fully restored LTP in slices from fragile X mice. These results indicate that the fragile X mutation produces a highly selective impairment to LTP, possibly at a step downstream of actin filament assembly, and suggest a means for overcoming this deficit. The possibility of a pharmacological therapy based on these results is discussed.# Fragile Xの原因自体は修復不可能だけど、症状を回復することが出来るなら素晴らしい
# hub氏経由…Dr. Humeが移籍するそうな
# この数が脳死診断したうちの何%なのか、どの位の確率で回復するのかという数字も必要だと思うが…
# 利他的行動は高度な社会性ということか
# 何ともまたややこしいことをおっしゃってます
# だからさぁ、そんなに極端にpHが下がるのかって？
Richard Thomas Clinghan, Graham P Arnold, Tim S Drew, Lynda Cochrane, Rami J Abboud.
Br J Sports Med. Published Online First | doi:10.1136/bjsm.2007.038844
# 一応、科学ニュースですので…
# SETIってどうなったんだっけ？
