# 少しずつでも吐き出していかないと…
Biotechnology Japan | Fred Hutchinsonがん研究センターの築山氏ら、ATP依存性の2つのクロマチン再構成複合体がDNA複製分岐点の進行を特定部位で制御していることを発見
ATP-dependent chromatin remodeling shapes the DNA replication landscape.
Jack A Vincent, Tracey J Kwong, Toshio Tsukiyama.
Nature Structural & Molecular Biology, Advance online publication | doi:10.1038/nsmb.1419
NIKKEI NET（日経ネット）：主要ニュース－乳製品多く飲食の男性、前立腺がんリスク1.6倍・厚労省
前立腺がん：乳製品食べる男性、発症率が１．６倍に - 毎日ｊｐ(毎日新聞)
乳製品、飽和脂肪酸、カルシウム摂取量と前立腺がんとの関連について -- 概要 --
Dairy Product, Saturated Fatty Acid, and Calcium Intake and Prostate Cancer in a Prospective Cohort of Japanese Men.
Norie Kurahashi, Manami Inoue, Motoki Iwasaki, Shizuka Sasazuki, Shoichiro Tsugane.
Cancer Epidemiology Biomarkers & Prevention 17, 930-937 (2008) | doi: 10.1158/1055-9965.EPI-07-2681
# 乳製品の窃取を控えるべきかも判断は時期尚早…
asahi.com： 「オーダーメード医療」、日米研究機関がタッグ - サイエンス
理研CGMと米国NIHが国際薬理遺伝学研究連合を創設 | 独立行政法人 理化学研究所プレスリリース
# 「血液から４５分で遺伝子のタイプを見分ける装置」…どんなんなんだろう？
asahi.com： 失った肉声をＰＣで再生 がん手術の教授、教壇に戻る - サイエンス
# 100万円かぁ…補助はないのかしら？
asahi.com： 天の川銀河の中心に巨大ブラックホール 京大など解明 - サイエンス
銀河中心の「眠れる大ブラックホール」 一時期激しく活動 - MSN産経ニュース
Suzaku Detection of Extended/Diffuse Hard X-Ray Emission from the Galactic Center.
Takayuki Yuasa, Ken-ichi Tamura, Kazuhiro Nakazawa, Motohide Kokubun, Kazuo Makishima, Aya Bamba, Yoshitomo Maeda, Tadayuki Takahashi, Ken Ebisawa, Atsushi Senda, Yoshiaki Hyodo, Takeshi Go Tsuru, Katsuji Koyama, Shigeo Yamauchi, Hiromitsu Takahashi.
arXiv:0709.1580v1 [astro-ph]
Jack A Vincent, Tracey J Kwong, Toshio Tsukiyama.
Nature Structural & Molecular Biology, Advance online publication | doi:10.1038/nsmb.1419
The eukaryotic DNA replication machinery must traverse every nucleosome in the genome during S phase. As nucleosomes are generally inhibitory to DNA-dependent processes, chromatin structure must undergo extensive reorganization to facilitate DNA synthesis. However, the identity of chromatin-remodeling factors involved in replication and how they affect DNA synthesis is largely unknown. Here we show that two highly conserved ATP-dependent chromatin-remodeling complexes in Saccharomyces cerevisiae, Isw2 and Ino80, function in parallel to promote replication fork progression. As a result, Isw2 and Ino80 have especially important roles for replication of late-replicating regions during periods of replication stress. Both Isw2 and Ino80 complexes are enriched at sites of replication, suggesting that these complexes act directly to promote fork progression. These findings identify ATP-dependent chromatin-remodeling complexes that promote DNA replication and define a specific stage of replication that requires remodeling for normal function.# クロマチン構造と複製…当然関わっているんだろうけど複雑そうだな
Norie Kurahashi, Manami Inoue, Motoki Iwasaki, Shizuka Sasazuki, Shoichiro Tsugane.
Cancer Epidemiology Biomarkers & Prevention 17, 930-937 (2008) | doi: 10.1158/1055-9965.EPI-07-2681
Many epidemiologic studies have reported a positive association between dairy products and prostate cancer. Calcium or saturated fatty acid in dairy products has been suspected as the causative agent. To investigate the association between dairy products, calcium, and saturated fatty acid and prostate cancer in Japan, where both the intake of these items and the incidence of prostate cancer are low, we conducted a population-based prospective study in 43,435 Japanese men ages 45 to 74 years. Participants responded to a validated questionnaire that included 138 food items. During 7.5 years of follow-up, 329 men were newly diagnosed with prostate cancer. Dairy products were associated with a dose-dependent increase in the risk of prostate cancer. The relative risks (95% confidence intervals) comparing the highest with the lowest quartiles of total dairy products, milk, and yogurt were 1.63 (1.14-2.32), 1.53 (1.07-2.19), and 1.52 (1.10-2.12), respectively. A statistically significant increase in risk was observed for both calcium and saturated fatty acid, but the associations for these were attenuated after controlling for potential confounding factors. Some specific saturated fatty acids increased the risk of prostate cancer in a dose-dependent manner. Relative risks (95% confidence intervals) on comparison of the highest with the lowest quartiles of myristic acid and palmitic acid were 1.62 (1.15-2.29) and 1.53 (1.07-2.20), respectively. In conclusion, our results suggest that the intake of dairy products may be associated with an increased risk of prostate cancer.# 乳製品中のカルシウムと飽和脂肪酸が原因なのか、その他の要因があるのかは不明…
# 乳製品の窃取を控えるべきかも判断は時期尚早…
# 「血液から４５分で遺伝子のタイプを見分ける装置」…どんなんなんだろう？
# 100万円かぁ…補助はないのかしら？
Takayuki Yuasa, Ken-ichi Tamura, Kazuhiro Nakazawa, Motohide Kokubun, Kazuo Makishima, Aya Bamba, Yoshitomo Maeda, Tadayuki Takahashi, Ken Ebisawa, Atsushi Senda, Yoshiaki Hyodo, Takeshi Go Tsuru, Katsuji Koyama, Shigeo Yamauchi, Hiromitsu Takahashi.
arXiv:0709.1580v1 [astro-ph]
Five on-plane regions within +/- 0.8deg of the Galactic center were observed with the Hard X-ray Detector (HXD) and the X-ray Imaging Spectrometer (XIS) onboard Suzaku. From all regions, significant hard X-ray emission was detected with HXD-PIN up to 40 keV, in addition to the extended plasma emission which is dominant in the XIS band. The hard X-ray signals are inferred to come primarily from a spatially extended source, rather than from a small number of bright discrete objects. Contributions to the HXD data from catalogued X-ray sources, typically brighter than 1 mCrab, were estimated and removed using information from Suzaku and other satellites. Even after this removal, the hard X-ray signals remained significant, exhibiting a typical 12--40 keV surface brightness of 4E-10 erg cm-2 s-1 deg-2 and power-law-like spectra with a photon index of 1.8. Combined fittings to the XIS and HXD-PIN spectra confirm that a separate hard tail component is superposed onto the hot thermal emission, confirming a previous report based on the XIS data. Over the 5--40 keV band, the hard tail is spectrally approximated by a power law of photon index ~2, but better by those with somewhat convex shapes. Possible origins of the extended hard X-ray emission are discussed.# 眠れるブラックホール…起きたら怖い？