High frequency of fluoroquinolone- and macrolide-resistant streptococci among clinically isolated group B streptococci with reduced penicillin susceptibility
J Antimicrob Chemother 2013; 68: 539–542
Kouji Kimura1,2*, Noriyuki Nagano3, Yukiko Nagano2, Satowa Suzuki2, Jun-ichi Wachino1,2, Keigo Shibayama2 and Yoshichika Arakawa1,2
57株のGBSについて今回調査；Fifty-seven GBS (19 PRGBS and 38 PSGBS) were isolated from blood or respiratory specimens in Japan between 2001 and 2008.
PRGBS；penicillin耐性（PBP 2X）, PSGBS ;ペニシリン感受性
感受性；the agar dilution method recommended by the CLSI using Streptococcus pneumoniae ATCC 49619 as the quality-control strain.
耐性；キノロン；gyrA, gyrB, parC and parE genes
マクロライド；erm(TR), erm(B) and mef(A/E), we performed PCR amplification of these partial genes using primers described previousl
結果；The frequency of non-susceptibility to FQs among PSGBS was 18.4% (7/38), whereas that among PRGBS was 100% (19/19). The frequency of resistance to erythromycin among PSGBS was 7.9% (3/38), while that among PRGBS was 47.4% (9/19).
→ペニシリン耐性株ではキノロン耐性株、マクロライド耐性株が多く、耐性遺伝子も複数に渡っている。
J Antimicrob Chemother 2013; 68: 539–542
Kouji Kimura1,2*, Noriyuki Nagano3, Yukiko Nagano2, Satowa Suzuki2, Jun-ichi Wachino1,2, Keigo Shibayama2 and Yoshichika Arakawa1,2
57株のGBSについて今回調査；Fifty-seven GBS (19 PRGBS and 38 PSGBS) were isolated from blood or respiratory specimens in Japan between 2001 and 2008.
PRGBS；penicillin耐性（PBP 2X）, PSGBS ;ペニシリン感受性
感受性；the agar dilution method recommended by the CLSI using Streptococcus pneumoniae ATCC 49619 as the quality-control strain.
耐性；キノロン；gyrA, gyrB, parC and parE genes
マクロライド；erm(TR), erm(B) and mef(A/E), we performed PCR amplification of these partial genes using primers described previousl
結果；The frequency of non-susceptibility to FQs among PSGBS was 18.4% (7/38), whereas that among PRGBS was 100% (19/19). The frequency of resistance to erythromycin among PSGBS was 7.9% (3/38), while that among PRGBS was 47.4% (9/19).
→ペニシリン耐性株ではキノロン耐性株、マクロライド耐性株が多く、耐性遺伝子も複数に渡っている。
