| 論文番号 | 著者名 | 論文タイトル名 | 発表雑誌名 | 巻、号 | ページ | 出版年 |
| 論文#10 | Kase H, Hattori Y, Jojima T, Okayasu T, Tomizawa A, Suzuki K, Banba N, Monden T, Satoh H, Akimoto K, Kasai K. | Globular adiponectin induces adhesion molecule expression through the sphingosine kinase pathway in vascular endothelial cells. | Life Sciences | 81(11) | 939-943 | 2007 |
| 論文#13 | Wang X, Hattori Y, Satoh H, Iwata C, Banba N, Monden T, Uchida K, Kamikawa Y, Kasai K. | Tetrahydrobiopterin prevents endothelial dysfunction and restores adiponectin levels in rats. | Eur J Pharmacol. | 555(1) | 48-53 | 2007 |
| 論文#14 | Hattori Y, Suzuki K, Hattori S, Kasai K. | Metformin inhibits Cytokine-Induced NF-kB Activation via AMPK Activation in Vascular Endothelial Cells | Hypertension | 47(6) | 1183-1188 | 2006 |
| 論文#16 | Kase H, Hashikabe Y, Uchida K, Nakanishi N, Hattori Y. | Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress | J Hypertens | 23 | 1375-1382 | 2005 |
(A)- 指摘項目No.27
論文#10のFigure 3 (C)の再下段のMCP-１の画像全６列分は、
論文#13のFigure 4 (A)のiNOSの画像全６列分（Fruct, Fruct/BH4の画像）や、
論文#16のFigure 5 (b)のiNOS Proteinの画像右６列分（BH4 only, AngII, AngII/BH4の画像）と、
類似しており、画像の流用（データ捏造）が疑われます。
(A)- 指摘項目No.28
論文#13のFigure 4 (A) のeNOSの画像全６列分は、
論文#16のFigure 5 (a)のeNOS Proteinの画像右６列分（BH4 only, AngII, AngII/BH4の画像）と、類似している。
さらに、この二つの画像は、
論文#14のFigure 4(B)のMCP-1の画像の左から3,4,5,6,7,8列目の６列分の画像を左右逆にした画像にも、
類似しており、画像の流用（データ捏造）が疑われます。
↓論文#10のFigure 3 (C)
Copyright (C) Elsevier Inc. All rights reserved.
Life Sciences 81 (2007) 939–943
Fig. 3. SKase activation is involved in globular adiponectin-induced activation
of NF-κB and adhesion molecule expression. (A) Treatment of cells with SKase
siRNA inhibited globular adiponectin-induced NF-κB activation. Data are
means±SD of at least three independent repetitions. ⁎Pb0.01 compared with
the value of gAd. (B) Treatment of cells with SKase siRNA markedly decreased
adiponectin-induced mRNA levels of adhesion protein expression. White bars:
control, grey bars: control treated with SKase siRNA, black bars: gAd, hatched
bars: gAd treated with SKase siRNA. Data are means±SD of at least three
independent repetitions and are shown as ratios against GAPDH. ⁎Pb0.01
compared with the value of gAd. (C) Treatment of cells with siRNA suppressed
globular adiponectin-induced protein levels of VCAM-1, ICAM-1, E-selectin,
and MCP-1. Experiments were performed in duplicate.
↓上記論文#13のFigure 4
Copyright (C) 2006 Elsevier B.V. All rights reserved.
European Journal of Pharmacology 555 (2007) 48–53
Fig. 4. Protein levels of eNOS and iNOS in aortic tissue were evaluated by
Western blot analysis. Results are expressed as means±S.D. of n=4 rats.
aPb0.05 vs. control rats. bPb0.05 vs. fructose+BH4 rats. C: control, F: fructose,
F/B: fructose/BH4.
↓上記論文#14のFigure 4
Hypertension. 2006;47:1183-1188 © 2006 American Heart Association, Inc. Figure 4. (A) Effects of metformin on TNF-–induced VCAM-1, E-selectin, ICAM-1, and MCP-1 mRNA expression. Metformin dose-dependently inhibited VCAM-1, E-selectin, ICAM-1, and MCP-1 mRNA levels. Each bar represents the meanSEM (n4). *P0.01. (B) Effects of metformin on TNF-–induced MCP-1 expression. Metformin dose-dependently inhibited MCP-1 protein levels.
↓上記論文#16のFigure 5
Copyright (C) 2005 Lippincott Williams & Wilkins
Journal of Hypertension 2005, 23:1375–1382
解説図：指摘項目No.28
