In the online May 2 issue of the journal Cell Metabolism, researchers at the University of California, San Diego School ofMedicine publish three distinct articles exploring: the complex interactions of lipids and inflammation in insulinresistance the roles of omega 3 fatty acids and a particular gene in fightinginflammation how elevated levels of a particular protein might delay themuscle-destroying effects of amyotrophic lateral sclerosis . Type 2 diabetes has reached epidemic proportions around the world, fueled in largepart by the equally alarming expansion of obesity as a global health problem. But while it's well-known that obesityis the most common cause of insulin resistance - the primarymetabolic abnormality in type 2 diabetes - researchers have onlyrecently begun to effectively parse the underlying, complicatedrelationships between lipids (fats and related molecules essentialto cell structure and function) and chronic tissue inflammation (akey cause of obesity-induced insulin resistance). In a wide-ranging Perspective article published in Cell Metabolism , Christopher K. Glass, MD, PhD, a professor in the departments ofCellular and Molecular Medicine, and Medicine at the UC San Diego,and Jerrold M. Pet Carrier Bags
Olefsky, MD, associate dean for Scientific Affairsand Distinguished Professor of Medicine at UC San Diego, surveywhere the science stands, describing, for example, thepro-inflammatory effects of saturated fatty acids and theanti-inflammatory benefits of omega 3 fatty acids. They alsodiscuss how inflammation impacts lipid metabolism at the cellular,tissue, organ and whole-body levels. In a second, related article, Olefsky and colleague Da Young Oh, anassistant project scientist, discuss the critical role of a genecalled GPR120 in inhibiting pro-inflammatory macrophages whilesimultaneously boosting the anti-inflammatory benefits of omega 3fatty acids. They argue that new research highlights the importanceof GPR120 as an attractive target for new drugs that could increaseinsulin sensitivity and, perhaps, have anti-obesity effects aswell. Finally, Don W. ipad Protective Sleeve Manufacturer
Cleveland, PhD, professor and chair of theDepartment of Cellular and Molecular Medicine and head of theLaboratory of Cell Biology at the Ludwig Institute for CancerResearch at UC San Diego and colleagues report the effects ofelevated levels of a gene-regulating protein in mouse cellsafflicted by a form of amyotrophic lateral sclerosis or ALS. In humans, ALS is a progressive, adult-onset neurodegenerativedisorder characterized by selective motor neuron and muscle lossthat ultimately results in fatal paralysis. Among the key playersin muscle function is a transcriptional activator protein calledPGC-1alpha, which helps enhance various aspects of muscle cellfunction, including metabolism and mitochondrial biogenesis. Cleveland and colleagues report that elevated levels of PGC-1alphain the muscles of a mouse model of inherited ALS helps maintainhealth and function, though it does not extend survival time. Theresearchers suggest that increasing PCG-1alpha activity in musclecould be a new and attractive therapeutic target for maintaining,improving and extending physical abilities in ALS patients. Recycled Shopping Bags Manufacturer
Additional References Citations.
Olefsky, MD, associate dean for Scientific Affairsand Distinguished Professor of Medicine at UC San Diego, surveywhere the science stands, describing, for example, thepro-inflammatory effects of saturated fatty acids and theanti-inflammatory benefits of omega 3 fatty acids. They alsodiscuss how inflammation impacts lipid metabolism at the cellular,tissue, organ and whole-body levels. In a second, related article, Olefsky and colleague Da Young Oh, anassistant project scientist, discuss the critical role of a genecalled GPR120 in inhibiting pro-inflammatory macrophages whilesimultaneously boosting the anti-inflammatory benefits of omega 3fatty acids. They argue that new research highlights the importanceof GPR120 as an attractive target for new drugs that could increaseinsulin sensitivity and, perhaps, have anti-obesity effects aswell. Finally, Don W. ipad Protective Sleeve Manufacturer
Cleveland, PhD, professor and chair of theDepartment of Cellular and Molecular Medicine and head of theLaboratory of Cell Biology at the Ludwig Institute for CancerResearch at UC San Diego and colleagues report the effects ofelevated levels of a gene-regulating protein in mouse cellsafflicted by a form of amyotrophic lateral sclerosis or ALS. In humans, ALS is a progressive, adult-onset neurodegenerativedisorder characterized by selective motor neuron and muscle lossthat ultimately results in fatal paralysis. Among the key playersin muscle function is a transcriptional activator protein calledPGC-1alpha, which helps enhance various aspects of muscle cellfunction, including metabolism and mitochondrial biogenesis. Cleveland and colleagues report that elevated levels of PGC-1alphain the muscles of a mouse model of inherited ALS helps maintainhealth and function, though it does not extend survival time. Theresearchers suggest that increasing PCG-1alpha activity in musclecould be a new and attractive therapeutic target for maintaining,improving and extending physical abilities in ALS patients. Recycled Shopping Bags Manufacturer
Additional References Citations.