家畜ヤギ（Capra hircus）ゲノムの配列解読…

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家畜ヤギ（Capra hircus）ゲノムの配列解読および全ゲノ
http://p213.pctrans.mobile.yahoo-net.jp/fweb/09125lCRhx1VRqwY/0?_jig_=http%3A%2F%2Fwww.nature.com%2Fnbt%2Fjournal%2Fv31%2Fn2%2Fabs%2Fnbt.2478_ja.html%3Flang%3Dja&_jig_keyword_=%90%F5%90F%91%CC%20%8ER%97r&_jig_done_=http%3A%2F%2Fsearch.mobile.yahoo.co.jp%2Fp%2Fsearch%2Fpcsite%2Flist%3Fp%3D%2590%25F5%2590F%2591%25CC%2B%258ER%2597r%26b%3D31%26trans%3D1&_jig_source_=srch&guid=on


Article abstract
Nature Biotechnology 31, 135 - 141 (2013)
doi:10.1038/nbt.2478Subject terms:Computational biology|Biotechnology|Animal biotechnology|Databases
家畜ヤギ（Capra hircus）ゲノムの配列解読および全ゲノム自動光学マッピング
Yang Dong1,2,12, Min Xie3,12, Yu Jiang1,5,12, Nianqing Xiao10,12, Xiaoyong Du4,12, Wenguang Zhang1,6,12, Gwenola Tosser-Klopp7, Jinhuan Wang1, Shuang Yang3, Jie Liang3, Wenbin Chen3, Jing Chen3, Peng Zeng3, Yong Hou3, Chao Bian3, Shengkai Pan3, Yuxiang Li3, Xin Liu3, Wenliang Wang3, Bertrand Servin7, Brian Sayre11, Bin Zhu10, Deacon Sweeney10, Rich Moore10, Wenhui Nie1, Yongyi Shen1,2, Ruoping Zhao1, Guojie Zhang3, Jinquan Li6, Thomas Faraut7, James Womack9, Yaping Zhang1, James Kijas5, Noelle Cockett8, Xun Xu1,2,3, Shuhong Zhao4, Jun Wang3& Wen Wang1This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

Abstract
本論文では雌の雲南黒ヤギのゲノム配列約2.66 Gbを示す。この配列は短いリードの配列解読データと高処理能全ゲノムマッピング装置による光学マッピングデータとを組み合わせて得られたものである。この全ゲノムマッピングデータは、フォスミド末端配列解読で増強したスキャフォールドとの比較でN50値が5倍以上長い超スキャフォールドの組み立てに有用である（スキャフォールド N50＝3.06 Mb、超スキャフォールド N50＝16.3 Mb）。超スキャフォールドはウシとの保存シンテニーに基づいて染色体との対応付けを行い、その組み立ては1番染色体の2種類の放射線ハイブリッド地図によって十分に裏付けられた。タンパク質をコードする遺伝子2万2,175個のアノテーションを行ったところ、その多くは10種類の組織のRNA配列解読データでも確認された。カシミヤヤギの1次および2次毛包の比較トランスクリプトーム解析からは、この2種類の毛包で差次的に発現する遺伝子51個が明らかになった。本研究の結果はヤギのゲノミクスに有用であり、全ゲノムマッピング技術が大きな
ゲノムの新規組み立てに利用可能であることを示している。
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State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
University of Chinese Academy of Sciences, Beijing, China.
BGI-Shenzhen, Shenzhen, China.
Huazhong Agricultural University, Wuhan, China.
CSIRO Livestock Industries, St. Lucia, Australia.
Inner Mongolia Agricultural University, Hohhot, China.
INRA Laboratoire de Gntique Cellulaire, Castanet-Tolosan, France.
Utah State University, Logan, Utah, USA.
Texas A&M University, College Station, Texas, USA.
OpGen, Inc., Gaithersburg, Maryland, USA.
Virginia State University, Petersburg, Virginia, USA.
These authors contributed equally to this work.
Correspondence to: Wen Wang1e-mail: wwang@mail.kiz.ac.cn Correspondence to: Jun Wang3e-mail: wangj@genomics.cn Correspondence to: Shuhong Zhao4e-mail: shzhao@mail.hzau.edu.cn Correspondence to: Xun Xu1,2,3e-mail: xuxun@genomics.cn


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