肺高血圧症と女性ホルモン【１】
医学雑誌のトップ記事には、論説、総説、その号の目玉となるような論文の紹介など、が用意されます。トップで掲載される論文、記事にはそれなりの意味があるのです。
米国発雑誌のある号のトップに、千葉大学からのレポートがPerspectiveとして掲載されました。Perspectiveは「観点，見地，視野，視点，透視図，展望」などと和訳されますが、簡単に言うと、総説論文をすこし短く簡単にしたものと考えてよろしいかと思います。自分の研究成果を発表するのではなく、あるトピックについて最新の知見をまとめて論文にしたものです。
この論文は2010年7月に掲載されましたが、3ヵ月後には撤回されました。
撤回の理由は盗作です。別の著者らが書いた論文をそのまま写して、自分が書いたものとして発表したわけです。
別の論文の内容の一部を下に示します。
Gender differences have also been described in pulmonary vascular disease. In the setting of chronic hypoxia, female Sprague-Dawley rats have been noted to exhibit less severe pulmonary hypertension (PH) than their male counterparts.
Similar results have been reported in other animals. Interestingly, chronically hypoxic ovariectomized rats develop more severe PA remodeling and right ventricular hypertrophy than chronically hypoxic rats with intact ovaries. Exogenous estrogen attenuates the severity of PH in the ovariectomized animals. Along these lines, male mice are less resistant than females when exposed to hypoxia. Treatment of ovariectomized females or castrated males with estradiol increases survival. In another model, ovariectomized rats exposed to monocrotaline (a plant toxin that induces progressive pulmonary vascular injury resulting in PH and right ventricular failure) exhibit more severe disease than intact rats. This can be attenuated by the administration of the estradiol metabolite 2-ME. Chronic hypoxia-induced PH in male rats can also be attenuated by 2-ME.
一方千葉大学からの論文の一部は上で示したものと一字一句ほぼ同じです。Estrogen exerts a beneficial effect on the pulmonary vasculature in hypoxic animal models. Female Sprague-Dawley rats exposed to chronic hypoxia have been noted to exhibit less severe PH than their male counterparts.
Similar results have also been reported in other animals. Interestingly, chronically hypoxic ovariectomized rats develop more severe PA remodeling and right ventricular hypertrophy than chronically hypoxic rats with intact ovaries.
Exogenous estrogen attenuates the severity of PH in the ovariectomized animals. Along these lines, male mice are less resistant than females when exposed to hypoxia . The treatment of ovariectomized females or castrated males with estradiol increases survival. In another model, ovariectomized rats exposed to monocrotaline exhibit more severe disease than intact rats . This can be attenuated by the administration of the estradiol metabolite 2-ME. Chronic hypoxia-induced PH in male rats can also be attenuated by 2-ME.
丸写しであることが、お判りになると思います。さてこの論文の撤回さらた理由は、盗作以外に別の理由があるとされています。
肺高血圧症と女性ホルモン【２】に続きます。
