A drive to improve quality, yield, and cycle time coupled withdesire for high personal performance has led to novel chemistrymethodologies enabling a wide range of reactions in productdevelopment. A METTLER TOLEDO white paper explores theinterrelationship of two of these critical methodologies, flowchemistry and mid-infrared spectroscopy , in today"s highly competitive R&D environment. METTLER TOLEDO is pleased to announce that a new white paperentitled "Enhanced Development and Control of ContinuousProcesses: A Review of Modern Technologies" is joining thecompany"s extensive collection of thought-leadershipresources. The new paper reviews flow chemistry"s revolutionary role inpharmaceutical and fine chemistry environments, including itsability to enhance product quality, increase yield, elucidatesynthetic route and improve reaction safety, all while reducingcycle time, which is critical to reducing development costs andcapturing market share in today"s competitive manufacturingarena.
The paper explores mid-infrared (IR) spectroscopy as a convenient and nondestructive method for real-time inlineflow chemistry monitoring, because it allows real-timedata-gathering on the formation of products and reactiveintermediates. This instantaneous feedback on how changing aparameter such as flow rate or reaction temperature affects areaction enables faster, safer and more cost-effective processoptimization. The intensity of IR energy absorbed at a particular wavelength isdefined by Beer"s law to be proportional to concentration,making it possible to track the relative concentration ofindividual reaction components using mid-IR-enabled technology.Employing this type of technology not only results in improvedreaction understanding; it also allows researchers to overcome whatused to be significant optimization issues, such as making acontrolled addition of reagent stoichiometries to a product streamusing output data from a prior reaction stage when performingmulti-step synthesis. The paper describes specific instances where mid-IR technology andflow chemistry principles were applied to monitor productstreams/dispersion effects in continuous flow reactors and allowedsuccessful third-stream reagent addition, helping to eliminate poorreaction control and the waste it produces. For a copy of the white paper, please visit: /flowchemwp About METTLER TOLEDO METTLER TOLEDO provides the enabling technology, software andpeople that can help build a seamless workflow to translate benchscale chemistry into a commercial process.
For more than 20 years,our enabling tools and services have been a strategic resourceproviding critical information for thousands of developmentscientists and engineers. Companies have used that knowledge toaccelerate the discovery, development and scale-up of new chemicalprocesses spanning the chemical and biopharmaceutical industries.For more, visit .
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The paper explores mid-infrared (IR) spectroscopy as a convenient and nondestructive method for real-time inlineflow chemistry monitoring, because it allows real-timedata-gathering on the formation of products and reactiveintermediates. This instantaneous feedback on how changing aparameter such as flow rate or reaction temperature affects areaction enables faster, safer and more cost-effective processoptimization. The intensity of IR energy absorbed at a particular wavelength isdefined by Beer"s law to be proportional to concentration,making it possible to track the relative concentration ofindividual reaction components using mid-IR-enabled technology.Employing this type of technology not only results in improvedreaction understanding; it also allows researchers to overcome whatused to be significant optimization issues, such as making acontrolled addition of reagent stoichiometries to a product streamusing output data from a prior reaction stage when performingmulti-step synthesis. The paper describes specific instances where mid-IR technology andflow chemistry principles were applied to monitor productstreams/dispersion effects in continuous flow reactors and allowedsuccessful third-stream reagent addition, helping to eliminate poorreaction control and the waste it produces. For a copy of the white paper, please visit: /flowchemwp About METTLER TOLEDO METTLER TOLEDO provides the enabling technology, software andpeople that can help build a seamless workflow to translate benchscale chemistry into a commercial process.
For more than 20 years,our enabling tools and services have been a strategic resourceproviding critical information for thousands of developmentscientists and engineers. Companies have used that knowledge toaccelerate the discovery, development and scale-up of new chemicalprocesses spanning the chemical and biopharmaceutical industries.For more, visit .
COB LED Ceiling Light is a suitable choice for enterprises that want to do business online, we provides low price and fine commodities such as LED Recessed Ceiling Lights, and many other products, just visit it !
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