トラスツズマブの胃癌での実用化が近くなってきました。このためには病理医がhuman epidermal growth factor receptor 2 (HER2)検査を判定する必要があります。胃癌におけるHER2検査に関する集まりが旧GHQビルの近くでありました。胃癌は乳癌に比べてheterogeneityが大変強いのが大きな問題点です。
Her2 IHC Scoring Proposal –acc. Pre-ToGA Study
DakoCytomation HercepTest™ （mod. for Gastric Cancer）
０： No / membrane staining in ＜10% of tumour cells
１＋： Faint / barely perceptible membrane staining in ＞10%; cells only stained in part of their membrane
２＋： Weak to moderate complete or baso-lateral membrane staining detected in ＞10% of tumour cells
３＋： Moderate to strong complete or baso-lateral membrane staining in ＞10% of tumour cells
Biopsy samples with cohesive either IHC 3+ and ⁄ or FISH+ clones are considered positive. Irrespective of size, i.e. ＜10%
(Hofmann et al. Histopathology 52:797-805, 2008)
Her2 IHC Scoring Proposal –acc. Pre-ToGA Study
DakoCytomation HercepTest™ （mod. for Gastric Cancer）
０： No / membrane staining in ＜10% of tumour cells
１＋： Faint / barely perceptible membrane staining in ＞10%; cells only stained in part of their membrane
２＋： Weak to moderate complete or baso-lateral membrane staining detected in ＞10% of tumour cells
３＋： Moderate to strong complete or baso-lateral membrane staining in ＞10% of tumour cells
Biopsy samples with cohesive either IHC 3+ and ⁄ or FISH+ clones are considered positive. Irrespective of size, i.e. ＜10%
(Hofmann et al. Histopathology 52:797-805, 2008)
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