抗神経型ニコチン性アセチルコリン受容体抗体とHLA-DRB1遺伝子の関連性

 

特定の遺伝子型が、特定の抗体（この場合は、自己免疫性自律神経節障害のマーカーとなっている抗受容体抗体）を作りやすいのではという結果を報告。

 

 

 

PLoS One. 2016 Jan 25;11(1):e0146048. doi: 10.1371/journal.pone.0146048. eCollection 2016.

Association between Anti-Ganglionic Nicotinic Acetylcholine Receptor (gAChR) Antibodies and HLA-DRB1 Alleles in the Japanese Population.

Maeda Y^1,2, Migita K³, Higuchi O¹, Mukaino A¹, Furukawa H⁴, Komori A³, Nakamura M⁵, Hashimoto S³, Nagaoka S³, Abiru S³, Yatsuhashi H³, Matsuo H¹, Kawakami A⁶, Yasunami M⁷, Nakane S⁸.

Author information

Abstract

BACKGROUND/AIMS:

Anti-ganglionic nicotinic acetylcholine receptor (gAChR) antibodies are observed in autoimmune diseases, as well as in patients with autoimmune autonomic ganglionopathy. However, the genetic background of anti-gAChR antibodies is unclear. Here, we investigated HLA alleles in autoimmune hepatitis (AIH) patients with or without anti-gAChR antibodies.

METHODOLOGY/PRINCIPAL FINDINGS:

Genomic DNA from 260 patients with type-1 autoimmune hepatitis (AIH) were genotyped for HLA-A, B, DRB1, and DQB1 loci. Anti-gAChR antibodies in the sera form AIH patients were measured using the luciferase immunoprecipitation system, and examined allelic association in patients with or without anti-gAChR antibodies.

METHODOLOGY/ METHODS:

We detected anti-α3 or -β4 gAChR antibodies in 11.5% (30/260) of patients with AIH. Among AIH patients there was no significant association between HLA-A, B DQB1 alleles and the positivity for anti-gAChR antibodies. Whereas the HLA-DRB1*0403 allele showed a significantly increased frequency in AIH patients with anti-gAChR antibodies compared with those without anti-gAChR antibodies.

CONCLUSIONS/SIGNIFICANCE:

The frequency of the HLA-DRB1*0403 allele differed among Japanese patients with AIH according to the presence or absence of anti-gAChR antibodies. Our findings suggest that particular HLA class II molecules might control the development of anti-gAChR antibodies in the autoimmune response to gAChR.