脳室拡大がプラセボの5倍
脳嚢胞が3件(プラセボ0件)
低酸素性虚血性脳症がプラセボの2倍
精巣捻転症2件(プラセボ0件)
プラセボに含まれているのは
0.11 mg tromethamine, 1.04 mg tromethamine hydrochloride, 11.3 mg sucrose, 22.5 mg mannitol, 0.08 mg polysorbate 80, and 1.1 mg sodium chloride per 0.5 mL
アブリスボの抗原は、Chinese Hamster Ovary cell lines からの不純物が含まれるので、ハムスターのタンパク質の糖鎖が危険だと思われる
勿論、DNAの汚染もある
(インフルエンザワクチンによるギランバレーの原因は、鶏卵由来の糖鎖であることは論文になっている)
placebo (0.5 mL dose, containing the same buffer ingredients in the same quantities as in a single dose of ABRYSVO
11 DESCRIPTION
ABRYSVO (Respiratory Syncytial Virus Vaccine) is a sterile solution for intramuscular injection. The vaccine is supplied as a vial of Lyophilized Antigen Component that is reconstituted at the time of use with a Sterile Water Diluent Component. The antigen component contains recombinant RSV preF A and RSV preF B.
The RSV preF A and RSV preF B recombinant proteins are expressed in genetically engineered Chinese Hamster Ovary cell lines grown in suspension culture using chemically-defined media, without antibiotics or animal-derived components. The recombinant proteins are purified through a series of column chromatography and filtration steps followed by formulation, filling into vials, and lyophilization.
After reconstitution, a single dose of ABRYSVO is formulated to contain 120 mcg of RSV stabilized prefusion F proteins (60 mcg RSV preF A and 60 mcg RSV preF B) per 0.5 mL. ABRYSVO also contains the following buffer ingredients: 0.11 mg tromethamine, 1.04 mg tromethamine hydrochloride, 11.3 mg sucrose, 22.5 mg mannitol, 0.08 mg polysorbate 80, and 1.1 mg sodium chloride per 0.5 mL. ABRYSVO is a sterile, clear, and colorless solution.
糖鎖相同性による自己免疫疾患の発症機序
結城 伸泰