イベルメクチンは、神経毒性が在りますが低用量使用だと神経毒性は、出ませんが高容量使用だと神経毒性が出ます。
イベルメクチンは、MDR1遺伝子により効き易い人と効き難い人がいますのでね。
イベルメクチンは、細胞のアポトーシスを引き起こす薬でマウスに投与したら神経毒性が出た事も在ります。
イベルメクチンが血中の新型コロナRNAを２４時間で９４%下げたのは、確認済みですが致死量投与する必要があるために新型コロナ感染症の薬として使う事は、出来ません。
イベルメクチンは、溶血性神経毒です。
下記引用論文等に在りませんが犬に神経毒性を示した事も在りますのでね。
Serious Neurological Adverse Events after Ivermectin—Do They Occur beyond the Indication of Onchocerciasis?
Serious neurological adverse events have been reported from large scale community-based ivermectin treatment campaigns against Onchocerciasis volvulus in Africa....
PubMed Central (PMC)
Re: Covid-19: Ivermectin’s politicisation is a warning sign for doctors turning to orphan treatments
The BMJ
Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy
Ivermectin (IVM) could cause potential neurotoxicity; however, the precise molecular mechanisms remain unclear. This study explores the cytotoxicity of IVM in hu...
PubMed Central (PMC)
5PSQ-157 Severe neurotoxicity of oral ivermectin: a systematic review of case and case series reports
Background and importance Ivermectin is a broad-spectrum antiparasitic. It was tested to treat COVID-19 but no benefit was found through large studies. Severe en...
European Journal of Hospital Pharmacy
Intravenous veterinary ivermectin in a COVID-19 patient causing neurotoxicity
Ivermectin administration for Coronavirus disease 2019 (COVID-19) infection has gained a lot of attention recently. Although ivermectin has a relative…
