MS96-14954 (1 slide) KIDNEY
Clinical: 61 year old white man with multiple nodules in the right kidney.
DX: Renal cell carcinoma, clear cell type, nuclear grade 2 of 4 (Fuhrman)
Comment: Clear cell type represents approx. 70% of RCCs. They are multicentric in only 4% of cases. An alveolar pattern with nests of clear cells separated by thin, vascular septae is typical.
FUHRMAN GRADING SYSTEM
Characteristics
I Nuclei round, uniform, approximately 10 micro-meters; nucleoli inconspicuous or absent
II Nuclei slightly irregular, approximately 15 micro-meters; nucleoli evident
III Nuclei very irregular, approximately 20 micro-meters; nucleoli large and prominent
IV Nuclei bizarre and multilobated, 20 micro-meters or greater; nucleoli prominent; chromatin clumped
(Stage is most important, but grade also correlates with survival.)
Clinical: 61 year old white man with multiple nodules in the right kidney.
DX: Renal cell carcinoma, clear cell type, nuclear grade 2 of 4 (Fuhrman)
Comment: Clear cell type represents approx. 70% of RCCs. They are multicentric in only 4% of cases. An alveolar pattern with nests of clear cells separated by thin, vascular septae is typical.
FUHRMAN GRADING SYSTEM
Characteristics
I Nuclei round, uniform, approximately 10 micro-meters; nucleoli inconspicuous or absent
II Nuclei slightly irregular, approximately 15 micro-meters; nucleoli evident
III Nuclei very irregular, approximately 20 micro-meters; nucleoli large and prominent
IV Nuclei bizarre and multilobated, 20 micro-meters or greater; nucleoli prominent; chromatin clumped
(Stage is most important, but grade also correlates with survival.)
