獨協医科大学の研究不正問題

獨協医科大学内分泌代謝内科研究室における 論文捏造・二重投稿の疑惑追及ブログ

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論文捏造についての科学雑誌編集者・出版社への申立て Part.1

2011年01月24日 | 科学雑誌編集者・出版社への申立て
・ 科学雑誌編集者・出版社への申立て
  申立てPart.1,  申立てPart.2,  申立てPart.3,  申立てPart.4
・ 申立てに対する、科学雑誌編集者・出版社からの返信メール
  返信Part.1返信Part.2返信Part.3



Journal of Atherosclerosis and Thrombosis誌への申立て

件名
JAT誌掲載の論文における捏造・改ざんにあたる研究不正行為に関する申立て
送信者
Juuichi Jigen <11jigen@mail.goo.ne.jp>
宛先
jas@kk-kyowa.co.jp
日時
2011年02月02日
_______________________________________

日本動脈硬化学会事務局 御中

Journal of Atherosclerosis and Thrombosis誌に掲載されている下記論文に関して捏造の可能性を確認しました。Figure 2(A)、2(B)、3(A)において、電気泳動画像の流用(捏造、改ざん)が認められます。詳細については、当論文の著者が所属する大学研究機関に送付するために当方が作成した告発文書をご覧下さい。私のホームページ(  http://blog.goo.ne.jp/11jigen_dokkyo_medical_univ_/c/79e83975d9623efb24a6415fe46d4130  )に掲載しています。今後の調査により、捏造などの研究不正行為が行われたと判断された場合、論文撤回の処置をお願いします。

↓ 捏造疑惑が持たれている論文
Anti-Inflammatory Role of Cilostazol in Vascular Smooth Muscle Cells In vitro and In vivo
Journal of Atherosclerosis and Thrombosis
Vol. 17 (2010) , No. 5 503-509
Chie Aoki1), Yoshiyuki Hattori1), Atsuko Tomizawa1), Teruo Jojima1) and Kikuo Kasai1)
1) Department of Endocrinology and Metabolism, Dokkyo University School of Medicine.
http://www.jstage.jst.go.jp/article/jat/17/5/17_503/_article




BBRC誌への申立て


First Name Sender: Juuichi
Last Name Sender: Jigen
Email Address: 11jigen@mail.goo.ne.jp
Subject: Allegation of fabrication and falsification
Journal ID: 622790
Journal Title: Biochemical and Biophysical Research Communications

Text of Email:
Please investigate fraudulent data of the article “Stimulated HSP90 binding to eNOS and activation of the PI3-Akt pathway contribute to globular adiponectin-induced NO production: Vasorelaxation in response to globular adiponectin” by Xi W, Satoh H, Kase H, Suzuki K, Hattori Y., published in
Biochem Biophys Res Common (2005 Jun 24;332(1):200-5.). You can find the falsified (fabricated) Figure 2 : namely, the HSP90 band for gAD(-)/GA(-) is quite similar to that for gAD(+)/GA(+).

References
1,
Biochem Biophys Res Common (2005 Jun 24;332(1):200-5.).
http://www.ncbi.nlm.nih.gov/pubmed/15896318






International Journal of Cardiology誌への申立て


Email Address: 11jigen@mail.goo.ne.jp
Subject: Allegations of fabrication and falsification
Journal ID: 506041
Journal Title: International Journal of Cardiology

Text of Email:

Please investigate fraudulent data of the article "Fluvastatin upregulates endothelial nitric oxide synthase activity via enhancement of its phosphorylation and expression and via an increase in tetrahydrobiopterin in vascular endothelial cells.” by Aoki C, Nakano A, Tanaka S, Yanagi K, Ohta S, Jojima T, Kasai K, Takekawa H, Hirata K, Hattori Y., published in
International Journal of Cardiology (Int J Cardiol. 2010 Nov 17." [Epub ahead of print]). You can find the fabricated (falsified) Figure 1(A) and 1(B) : namely, the p-Ser1177 eNOS (5,15,30,45,60) bands are quite similar to p-Ser633 eNOS (5,15,30,45,60) bands.

Reference
1,
Int J Cardiol. 2010 Nov 17. [Epub ahead of print]
Fluvastatin upregulates endothelial nitric oxide synthase activity via enhancement of its phosphorylation and expression and via an increase in tetrahydrobiopterin in vascular endothelial cells.
http://www.ncbi.nlm.nih.gov/pubmed/21093076







Cardiovasc Res誌への申立て
------------------------------------------------------------
Comments sent via CARDIOVASC RES Feedback Page
------------------------------------------------------------
NAME: Juuichi Jigen
EMAIL: 11jigen@mail.goo.ne.jp

------------------------------------------------------------
COMMENTS:
Please investigate fraudulent data of the article “Statin enhances cytokine-mediated induction of nitric oxide synthesis in vascular smooth muscle cells.” by Hattori Y, Nakanishi N, Kasai K., published in
Cardiovascular Research (2002 Jun;54(3):649-58.). You can find the falsified (fabricated) Figure 6 top panel : namely, the GTPCH band for BASE is quite similar to that for IL-1/IFN, and the GTPCH band for +Ceriva be similar to that for +Fluva.


References
1,
Cardiovascular Research (2002 Jun;54(3):649-58.)
http://cardiovascres.oxfordjournals.org/content/54/3/649.long





J Cardiovasc Pharmacol誌への申立て



From: Juuichi Jigen [mailto:11jigen@mail.goo.ne.jp]
To: Hurd, Emily; Sollenberger, Jennifer; Hee, Laurie
Subject: Allegations of fabrication and falsification

Please investigate fraudulent data of the article "Disruption of the
actin cytoskeleton up-regulates iNOS expression in vascular smooth
muscle cells." by Hattori Y, Kasai K. published in J Cardiovasc
Pharmacol. (2004 Feb;43(2):209-13.). You can find the fabricated
(falsified) Figure 3 : namely, Figure 3 of the above article [J
Cardiovasc Pharmacol. (2004 Feb;43(2):209-13.)] is identical to Figure 5
of another article [Biochim Biophys Acta. (2004 Aug 4;1689(3):267-72.)].


References
1
J Cardiovasc Pharmacol. 2004 Feb;43(2):209-13.
Disruption of the actin cytoskeleton up-regulates iNOS expression in
vascular smooth muscle cells.
Hattori Y, Kasai K.
http://www.ncbi.nlm.nih.gov/pubmed/14716207

2
Biochim Biophys Acta. 2004 Aug 4;1689(3):267-72.
Statin blocks Rho/Rho-kinase signalling and disrupts the actin
cytoskeleton: relationship to enhancement of LPS-mediated nitric oxide
synthesis in vascular smooth muscle cells.
Kato T, Hashikabe H, Iwata C, Akimoto K, Hattori Y.





BBA誌への申立て


Please investigate fraudulent data of the article "Statin blocks Rho/Rho-kinase signalling and disrupts the actin cytoskeleton:
relationship to enhancement of LPS-mediated nitric oxide synthesis in vascular smooth muscle cells”
by Kato T, Hashikabe H, Iwata C, Akimoto K, Hattori Y. published in
Biochim Biophys Acta. (2004 Aug 4;1689(3):267-72. ). You can find the fabricated (falsified) Figure 5 : namely,
Figure 5 of the above article [Biochim Biophys Acta. (2004 Aug 4;1689(3):267-72.)] is identical to
Figure 3 of another article [J Cardiovasc > Pharmacol. (2004 Feb;43(2):209-13.)]


References
1
Biochim Biophys Acta. 2004 Aug 4;1689(3):267-72.
Statin blocks Rho/Rho-kinase signalling and disrupts the actin cytoskeleton:
relationship to enhancement of LPS-mediated nitric > oxide synthesis in vascular smooth muscle cells.
Kato T, Hashikabe H, Iwata C, Akimoto K, Hattori Y.

2
J Cardiovasc Pharmacol. 2004 Feb;43(2):209-13.
Disruption of the actin cytoskeleton up-regulates iNOS expression in vascular smooth muscle cells.
Hattori Y, Kasai K.
http://www.ncbi.nlm.nih.gov/pubmed/14716207






Eur J Pharmacol誌への申立て


First Name Sender: Juuichi
Last Name Sender: Jigen
Email Address: 11jigen@mail.goo.ne.jp
Subject: Allegations of fabrication and falsification
Journal ID: 506087
Journal Title: European Journal of Pharmacology

Text of Email:
Please investigate fraudulent data of the article [Tetrahydrobiopterin prevents endothelial dysfunction and restores adiponectin levels in rats.] by Wang X, Hattori Y, Satoh H, Iwata C, Banba N, Monden T, Uchida K, Kamikawa Y, Kasai K.
published in Eur J Pharmacol [ 2007 Jan 19;555(1):48-53 ]. You can find the fabricated (falsified) Figure 4 : namely, iNOS Western blot image in Figure 4 of the above article [Eur J Pharmacol. 2007 Jan 19;555(1):48-53.] is identical to MCP-1 Western blot image in Figure 3(C) of another article [Life Sci. 2007 Aug 23;81(11):939-43.] and iNOS Protein Western blot images in Figure 5 of another article [J Hypertens. 2005 Jul;23(7):1375-82.].

Moreover, eNOS Western blot image in Figure 4 of the above article [Eur J Pharmacol. 2007 Jan 19;555(1):48-53.] is identical to eNOS Western blot image in Figure 5(a) of another article [J Hypertens. 2005 Jul;23(7):1375-82.] and MCP-1 Wstern blot image (left-right reversal) in Figure 4(B) of another article [Hypertension. 2006 Jun;47(6):1183-8.]



References
1
Eur J Pharmacol. 2007 Jan 19;555(1):48-53. Epub 2006 Oct 18.
Tetrahydrobiopterin prevents endothelial dysfunction and restores adiponectin levels in rats.
Wang X, Hattori Y, Satoh H, Iwata C, Banba N, Monden T, Uchida K, Kamikawa Y, Kasai K.

2
Life Sci. 2007 Aug 23;81(11):939-43. Epub 2007 Aug 17.
Globular adiponectin induces adhesion molecule expression through the sphingosine kinase pathway in vascular endothelial cells.
Kase H, Hattori Y, Jojima T, Okayasu T, Tomizawa A, Suzuki K, Banba N, Monden T, Satoh H, Akimoto K, Kasai K.

3
Hypertension. 2006 Jun;47(6):1183-8. Epub 2006 Apr 24.
Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells.
Hattori Y, Suzuki K, Hattori S, Kasai K.

4
J Hypertens. 2005 Jul;23(7):1375-82.
Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress.
Kase H, Hashikabe Y, Uchida K, Nakanishi N, Hattori Y.
Department of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi, Japan.







Life Sciences誌への申立て

件名
Allegations of fabrication and falsification [Life Sci. 2007 Aug 23;81(11):939-43.]
送信者
Juuichi Jigen <11jigen@mail.goo.ne.jp>
宛先
lifesci@elsevier.com


添付
Life Sci. 2007 81 939-43.pdf (402k)Eur J Pharmacol. 2007 555 48-53..pdf (445k)Hypertension. 2006 47 1183-8..pdf (355k)J Hypertens. 2005 23 1375-82..pdf (4,432k)
Please investigate fraudulent data of the article [Globular adiponectin induces adhesion molecule expression through the sphingosine kinase pathway in vascular endothelial cells.
] byKase H, Hattori Y, Jojima T, Okayasu T, Tomizawa A, Suzuki K, Banba N, Monden T, Satoh H, Akimoto K, Kasai K.
published in Life Sciences (2007 Aug 23;81(11):939-43.). You can find the fabricated (falsified) Figure 3(C) : namely, MCP-1 Western blot image in Figure 3(C) of the above article [Life Sci. 2007 Aug 23;81(11):939-43.] is identical to iNOS Western blot image in Figure 4 of another article [Eur J Pharmacol. 2007 Jan 19;555(1):48-53.] and iNOS Protein Western blot images in Figure 5 of another article [J Hypertens. 2005 Jul;23(7):1375-82.].

Moreover, eNOS Western blot image in Figure 4 of the above article [Eur J Pharmacol. 2007 Jan 19;555(1):48-53.] is identical to eNOS Western blot image in Figure 5(a) of another article [J Hypertens. 2005 Jul;23(7):1375-82.] and MCP-1 Wstern blot image (left-right reversal) in Figure 4(B) of another article [Hypertension. 2006 Jun;47(6):1183-8.]



References
1
Life Sci. 2007 Aug 23;81(11):939-43. Epub 2007 Aug 17.

2
Eur J Pharmacol. 2007 Jan 19;555(1):48-53. Epub 2006 Oct 18.

3
Hypertension. 2006 Jun;47(6):1183-8. Epub 2006 Apr 24.

4
J Hypertens. 2005 Jul;23(7):1375-82.








HYPERTENSION誌への申立て

------------------------------------------------------------
Comments sent via HYPERTENSION Feedback Page
------------------------------------------------------------
NAME: Juuichi Jigen
EMAIL: 11jigen@mail.goo.ne.jp

------------------------------------------------------------
COMMENTS:
Please investigate fraudulent data of the article
[Metformin inhibits cytokine-induced nuclear factor
kappaB activation via AMP-activated protein kinase
activation in vascular endothelial cells.] byHattori Y,
Suzuki K, Hattori S, Kasai K. published in
Hypertension. [ 2006 Jun;47(6):1183-8. ]. You can find
the fabricated (falsified) Figure 4(B) : namely, MCP-1
Wstern blot image in Figure 4(B) of the above article
[Hypertension. 2006 Jun;47(6):1183-8.] is identical to
eNOS Western blot image (left-right reversal) in Figure
4 of another article [Eur J Pharmacol. 2007 Jan
19;555(1):48-53.] eNOS Western blot image (left-right
reversal) in Figure 5(a) of another article [J
Hypertens. 2005 Jul;23(7):1375-82.] and

Moreover, iNOS Western blot image in Figure 4 of the
above article [Eur J Pharmacol. 2007 Jan 19;555(1):48-
53.] is identical to MCP-1 Western blot image in Figure
3(C) of another article [Life Sci. 2007 Aug
23;81(11):939-43.] and iNOS Protein Western blot images
in Figure 5 of another article [J Hypertens. 2005
Jul;23(7):1375-82.].



References
1
Hypertension. 2006 Jun;47(6):1183-8. Epub 2006 Apr 24.

2
Eur J Pharmacol. 2007 Jan 19;555(1):48-53. Epub 2006
Oct 18.

3
Life Sci. 2007 Aug 23;81(11):939-43. Epub 2007 Aug 17.

4
J Hypertens. 2005 Jul;23(7):1375-82.






J Hypertens誌への申立て

件名
Allegations of fabrication and falsification
送信者
Juuichi Jigen <11jigen@mail.goo.ne.jp>
宛先
Phil.Daly@wolterskluwer.com ; Magda.Lewandowska@wolterskluwer.com ; j.hypertension@centroipertensione.191.it ; alberto.zanchetti@unimi.it
CC
translationrights@w

J Hypertens. 2005 23 1375-82..pdf (4,432k)Hypertension. 2006 47 1183-8..pdf (355k)Eur J Pharmacol. 2007 555 48-53..pdf (445k)Life Sci. 2007 81 939-43.pdf (402k)



Please investigate fraudulent data of the article [Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress.
] by Kase H, Hashikabe Y, Uchida K, Nakanishi N, Hattori Y. published in J Hypertens. [2005 Jul;23(7):1375-82.]. You can find the fabricated (falsified) Figure 5(a) : namely, eNOS Western blot image in Figure 5(a) of another article [J Hypertens. 2005 Jul;23(7):1375-82.] is identical to eNOS Western blot image in Figure 4 of another article [Eur J Pharmacol. 2007 Jan 19;555(1):48-53.] and MCP-1 Wstern blot image (left-right reversal) in Figure 4(B) of another article [Hypertension. 2006 Jun;47(6):1183-8.] .

Moreover, iNOS Protein Western blot images in Figure 5 of the above article [J Hypertens. 2005 Jul;23(7):1375-82.] is identical to iNOS Western blot image in Figure 4 of another article [Eur J Pharmacol. 2007 Jan 19;555(1):48-53.] and MCP-1 Western blot image in Figure 3(C) of another article [Life Sci. 2007 Aug 23;81(11):939-43.] and.



References
1
J Hypertens. 2005 Jul;23(7):1375-82.

2
Hypertension. 2006 Jun;47(6):1183-8. Epub 2006 Apr 24.

3
Eur J Pharmacol. 2007 Jan 19;555(1):48-53. Epub 2006 Oct 18.

4
Life Sci. 2007 Aug 23;81(11):939-43. Epub 2007 Aug 17.






Metabolism誌への申立て
件名
Allegations of fabrication and falsification [Metabolism. 2005 Apr;54(4):482-7. ]
送信者
Juuichi Jigen <11jigen@mail.goo.ne.jp>
宛先
cmantzor@bidmc.harvard.edu
添付
Metabolism 2005 54 482-7 Hattori S.pdf (350k)
Diabetologia 2005 48 1066-74 HttoriY.pdf (398k)


Please investigate fraudulent data of the article "Hypoadiponectinemia is caused by chronic blockade of nitric oxide synthesis in rats.” by Hattori S, Hattori Y, Kasai K., published in
Metabolism (2005 Apr;54(4):482-7). You can find the fabricated (falsified) Figure 3(B) and 3(C) : namely,


(1) ・The Northern blot images of Figure 3(B) of [Diabetologia 2005 Jun;48(6):1066-74. ] are similar to those of Figure 2(B) of [Metabolism. 2005 Apr;54(4):482-7. ].
(2) ・The Northern blot images of Figure 3(C) of [Diabetologia 2005 Jun;48(6):1066-74. ] are similar to those of Figure 3(B) and 3(C) of [Metabolism. 2005 Apr;54(4):482-7. ].
(3) ・ The Northern blot images of L-NAME and L-NAME+Pio in Figure 3(B) are identical to those of L-NAME and L-NAME+All in Figure 3(C) [Metabolism. 2005 Apr;54(4):482-7. ].
(4) ・The Northern blot images of AngII and AngII+Tempol in Figure 3(C)’s top panel are identical to those of AngII and AngII+BH4 in Figure 3(C)’s bottom panel [Diabetologia 2005 Jun;48(6):1066-74. ].
(5) ・Three northern blot images of Adiponectin mRNA of Figure 3(B) (Diabetologia 2005 Jun;48(6):1066-74. ) resemble one another closely.



References

1
Metabolism. 2005 Apr;54(4):482-7.
Hypoadiponectinemia is caused by chronic blockade of nitric oxide synthesis in rats.
Hattori S, Hattori Y, Kasai K.
http://www.ncbi.nlm.nih.gov/pubmed/15798955

2
Diabetologia. 2005 Jun;48(6):1066-74. Epub 2005 Apr 30.
Angiotensin-II-induced oxidative stress elicits hypoadiponectinaemia in rats.
Hattori Y, Akimoto K, Gross SS, Hattori S, Kasai K.
http://www.ncbi.nlm.nih.gov/pubmed/15864528





Diabetologia誌への申立て


件名
Allegations of fabrication and falsification [Diabetologia 2005 Jun;48(6):1066-74. ]
送信者
Juuichi Jigen <11jigen@mail.goo.ne.jp>
宛先
diabetologia-j@bristol.ac.uk
添付
Diabetologia 2005 48 1066-74 HttoriY.pdf (398k)
Metabolism 2005 54 482-7 Hattori S.pdf (350k)


Please investigate fraudulent data of the article "Angiotensin-II-induced oxidative stress elicits hypoadiponectinaemia in rats” by Hattori Y, Akimoto K, Gross SS, Hattori S, Kasai K, published in
Diabetologia (2005 Jun;48(6):1066-74. ). You can find the fabricated (falsified) Figure 3(B) and 3(C) : namely,

(1) ・Three northern blot images of Adiponectin mRNA of Figure 3(B) (Diabetologia 2005 Jun;48(6):1066-74. ) resemble one another closely.
(2) ・The Northern blot images of Figure 3(B) of [Diabetologia 2005 Jun;48(6):1066-74. ] are identical to those of Figure 2(B) of [Metabolism. 2005 Apr;54(4):482-7. ].
(3) ・The Northern blot images of Figure 3(C) of [Diabetologia 2005 Jun;48(6):1066-74. ] are identical to those of Figure 3(B) and 3(C) of [Metabolism. 2005 Apr;54(4):482-7. ].
(4) ・The Northern blot images of AngII and AngII+Tempol in Figure 3(C)’s top panel are identical to those of AngII and AngII+BH4 in Figure 3(C)’s bottom panel [Diabetologia 2005 Jun;48(6):1066-74. ].



References

1
Diabetologia. 2005 Jun;48(6):1066-74. Epub 2005 Apr 30.

2
Metabolism. 2005 Apr;54(4):482-7.





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