獨協医科大学の研究不正問題

獨協医科大学内分泌代謝内科研究室における 論文捏造・二重投稿の疑惑追及ブログ

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申立てに対する科学雑誌編集者からの返信メール Part.2

2011年01月24日 | 科学雑誌編集者・出版社への申立て
・ 科学雑誌編集者・出版社への申立て
  申立てPart.1,  申立てPart.2,  申立てPart.3,  申立てPart.4
・ 申立てに対する、科学雑誌編集者・出版社からの返信メール
  返信Part.1返信Part.2返信Part.3



Hypertension Research誌からの返信メール


件名
件名なし
送信者
HypertensRes_eic <eic-htr@jpnsh.org>
宛先
11jigen@mail.goo.ne.jp
CC
'Masatsugu Horiuchi, EIC' <eic-htr@jpnsh.org>
日時
2011年02月07日 09:54:42
Dear Dr. Juuichi Jigen,

I have received your email.
Now, we are investigating this matter among the Editorial Board members.

Sincerely yours,

Masatsugu Horiuchi
Editor-in-Chief
Hypertension Research
The Japanese Society of Hypertension
Phone: +81-3-6801-9786 Fax: +81-3-6801-9787
E-Mail: hr-office@jpnsh.org



Dear Dr. Horiuchi (Editor-in-Chief of Hypertension Research),

Please investigate fraudulent data of the article “Telmisartan inhibits cytokine-induced nuclear factor-kappaB activation independently of the peroxisome proliferator-activated receptor-gamma. Nakano A, Hattori Y, Aoki C, Jojima T, Kasai K., published in Hypertens Research. (2009 Sep;32(9):765-9.). You can find fabricated (falsified) Figure 3(b) : namely,

(1)
The right-side 3 bands (first, second and third bands from right) of IkB-alpha image, top-panel in Figure 4(A) of Ref.2 are similar to the second, third and fourth bands from left of pAMPK image in Figure 1(A) of Ref.2.
Moreover, the first and second bands from left of IkB-alpha image, top-panel in Figure 4(A) of Ref.2 is similar to both the fifth and sixth bands from left of pAMPK image in Figure 1(A) of Ref.2 and the fifth and sixth bands from left of pAMPK image in Figure 1(a) of Ref.4..
Furthermore, the pAMPK image (all 7 bands) in Figure 1(A) of Ref.2 is similar to the pAMPK image (all 7 bands) in Figure 1(a) of Ref.4 ,and first to sixth bands from left of the above pAMPK image of Ref.2,9 are similar to the pAMPK image for cilostazol in Figure 1(D) of Ref.2 and the pAMPK image in Figure 2(A) of Ref.1 and the pAMPK image for Metformin in Figure 3(b) of Ref.3.
In addition, the rightside 5 bands (2.5 min 〓 60 min) of the pAMPK imgae in Figure 2(A) of Ref.1 are similar to upside-down and left-right reversal of the pAMPK image in Figure 3(A) of Ref.1.



__________________

References

1,
J Atheroscler Thromb. 2010;17(5):503-9. Epub 2010 Feb 24.

2,
Cardiovasc Res. 2009 Jan 1;81(1):133-9. Epub 2008 Aug 14.

3,
Hypertens Res. 2009 Sep;32(9):765-9. Epub 2009 Jul 10.

4.
Am J Hypertens. 2008 Apr;21(4):451-7. Epub 2008 Feb 7.



_____________________
Sincerely yours,

Juuichi Jigen
E-mail: 11jigen@mail.goo.ne.jp





Hypertension誌からの返信メール


件名
RE: Allegations of fabrication and falsification (Hypertension 2006 Jun;47(6):1183-8.)
送信者
John E. Hall <jehall@umc.edu>
宛先
'Juuichi Jigen' <11jigen@mail.goo.ne.jp> ; hypertension <hypertension@umc.edu>
CC
hypertension <hypertension@umc.edu>
日時
2011年02月07日 05:16:37


Dear Dr. Jigen,

We have reviewed the manuscript published in Hypertension (Hypertension 2006 Jun;47(6):1183-8.) as well as manuscripts 5 and 6 (referenced below) which you allege contain "similar" data/images.

We agree that the images appear to be similar, although not exactly the same. It is possible to have a "similar" image/data when one measures the same variable in different experiments.

We take charges of "fabricated" and "Falsified" data seriously. However, we will need additional information on why you believe the data published in Hypertension is "fabricated" or "falsified".

John E. Hall
Editor

-----Original Message-----
From: Juuichi Jigen [mailto:11jigen@mail.goo.ne.jp]
To: hypertension; John E. Hall
Cc: hypertension
Subject: Allegations of fabrication and falsification (Hypertension 2006 Jun;47(6):1183-8.)

Dear Dr.John E. Hall, Editor-in-Chief of Hypertension,


Please investigate fraudulent data of the article "Metformin inhibits Cytokine-Induced NF-kB Activation via AMPK Activation in Vascular Endothelial Cells" Hattori Y, Suzuki K, Hattori S, Kasai K., published in Hypertension (2006 Jun;47(6):1183-8.). You can find fabricated (falsified) Figure 3(A),(B),(C) and Figure 4(B) : namely,

(1)
The Phospho-IkB-alpha image in Figure 4(A) of Ref.1 is similar to the Phospho-IkB-alpha image in Figure 5(A) of Ref.2 and the Phospho-IkBa image in Figure 3(A) of Ref.4 and the Phospho IkB-alpha image in Figure 6(A) of Ref.6.

(2)
The IkB-alpha image in Figure 4(B) of Ref.1 is similar to the IKB-alpha image in Figure 5(B) of Ref.2 and the IkBa image in Figure 3(B) of Ref.4 and the leftside 4 bands of the ONOO-IkB-alpha image in Figure 6(A) of Ref.6.

(3)
The IkB-alpha image in Figure 5(A) of Ref.2 is similar to both the IkB-a image in Figure 3(A) of Ref.4 and the IkB-alpha image in Figure 6(A) of Ref.6.


(4)
The right-side 3 bands (second, third and fourth bands from left) of IkB-alpha image, top-panel in Figure 3(C) of Ref.4 is similar to the middle 3 bands (second, third and fourth bands from left) of IkB-alpha image, top-panel in Figure 6(B) of Ref.6.

(5)
The IKKa/b image in Figure 3(C) of Ref.4 is similar to the left-side 4 bands (first to fourth bands from left) of the IKKalpha/beta image, fifth panel from bottom in Figure 6(B) of Ref.6.
Moreover, the left-side 3 bands of these two images are similar to the IKKalpha/beta image, second panel from bottom in Figure 6(B) of Ref.6..

(6)
The IkB-a image, bottom panel in Figure 3(C) of Ref.4 is similar to the left-side 4 bands (first to fourth bands from left) of IkB-alpha image, fourth panel from bottom in Figure 6(B) of Ref.6.
Moreover, the left-side 3 bands of these image are similar to the IkB-alpha image, bottom panel in Figure 6(B) of Ref.6.

(7)
The eNOS image in Figure 4(A) of Ref.3 is similar to the right-side 6 bands (for BH4 only, AngII, AngII/BH4) of eNOS Protein image in Figure 5(a) of Ref.5.
Moreover, these two images are similar to the 6 bands (third to eighth bands from left) of the MCP-1 image in Figure 4(B) of Ref.4.

__________________

References

1
Cardiovasc Res. 2009 Jan 1;81(1):133-9. Epub 2008 Aug 14.

2,
Life Sci. 2008 Apr 9;82(15-16):884-91. Epub 2008 Feb 16.

3,
Eur J Pharmacol. 2007 Jan 19;555(1):48-53. Epub 2006 Oct 18.

4,
Hypertension. 2006 Jun;47(6):1183-8. Epub 2006 Apr 24.

5,
J Hypertens. 2005 Jul;23(7):1375-82.

6,
Cardiovasc Res. 2004 Jul 1;63(1):31-40.



__________________
Sincerely yours,

Juuichi Jigen
E-mail: 11jigen@mail.goo.ne.jp





Cardiovascular Research誌からの返信メール


AW: Allegations of fabrication and falsification (Cardiovasc Research 2009 11:143-9)
送信者
CVR, Martinson <CVR@physiologie.med.uni-giessen.de>
宛先
Juuichi Jigen <11jigen@mail.goo.ne.jp>
日時
2011年02月07日 22:50:37


Dear Juuichi Jigen,

We have received your emails and our publisher has contacted us regarding this case as well. This is just to inform you that we take the accusations seriously and will investigate this situation ourselves. I will let you know what our Editorial Team's reply will be in a few days.

With kind regards,
Elizabeth Martinson
___________________________________
Elizabeth A. Martinson, Ph.D.
Managing Editor, Cardiovascular Research
Institute of Physiology
Aulweg 129
35392 Giessen, GERMANY
Tel. +49 (0)641 99 47 242
Fax +49 (0)641 99 47 209
Email CVR@physiologie.med.uni-giessen.de


-----Ursprüngliche Nachricht-----
Von: Juuichi Jigen [mailto:11jigen@mail.goo.ne.jp]
An: CVR, Martinson
Betreff: Allegations of fabrication and falsification (Cardiovasc Research 2009 11:143-9)


Dear Dr. Hans Michael Piper,

Please investigate fraudulent data of the article “Cilostazol inhibits cytokine-induced nuclear factor-kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells.” Hattori Y, Suzuki K, Tomizawa A, Hirama N, Okayasu T, Hattori S, Satoh H, Akimoto K, Kasai K., published in Cardiovasc Research (2009 Feb;11(2):143-9). You can find fabricated (falsified) Figure 1(A),(B),(C),(D) and Figure4(A),(B),(C) : namely,

(1)
The first, second and third bands from right of IkB-alpha image, top-panel in Figure 4(A) of Ref.3 is similar to the second, third and fourth bands from left of pAMPK image in Figure 1(A) of Ref.3.
Moreover, the first and second bands from left of IkB-alpha image, top-panel in Figure 4(A) of Ref.3 is similar to both the fifth and sixth bands from left of pAMPK image in Figure 1(A) of Ref.3 and the fifth and sixth bands from left of pAMPK image in Figure 1(a) of Ref.7..
Furthermore, the pAMPK image (all 7 bands) in Figure 1(A) of Ref.3 is similar to the pAMPK image (all 7 bands) in Figure 1(a) of Ref.7 ,and first to sixth bands from left of the above pAMPK image of Ref.3,9 are similar to the pAMPK image for cilostazol in Figure 1(D) of Ref.3 and the pAMPK image in Figure 2(A) of Ref.2 and the pAMPK image for Metformin in Figure 3(b) of Ref.4.
In addition, the rightside 5 bands (2.5 min 〓 60 min) of the pAMPK imgae in Figure 2(A) of Ref.2 are similar to upside-down and left-right reversal of the pAMPK image in Figure 3(A) of Ref.2.

(2)
The AMPK image in Figure 1(A) of Ref.3 is similar to the APMK image in Figure 1(a) of Ref.7.
Moreover, the leftside 6 bands of these two APMK image are similar to the AMPK image in Figure 2(A) of Ref.2.
Furthermore, rightside 5 bands of this AMPK image in Figure 2(A) of Ref.2 are similar to the pAMPK image for Milrinone in Figure 1(D) of Ref.3


(3)
The rightside 5 bands of the AMPK image in Figure 1(B) of Ref.3 is similar to both the AMPK image in Figure 2(B) of Ref.2 and the AMPK image in Figure 1(b) of Ref.7.
Likewise, 5 bands (second to sixth bands from left) of pAMPK image in Figure 1(B) of Ref.3 are similar to the pAMPK image in Figure 2(B) of Ref.2 and the pAMPK image in Figure 1(b) of Ref.7.

(4)
The ACC and pACC images in Figure 1(A) of Ref.3 are similar to the ACC and pACC images in Figure 1(a) of Ref.7, respectively.
Moreover, the leftside 6 bands of these two images are similar to the ACC and p-ACC images in Figure 2(A) of Ref.2.

(5)
The Phospho-IkB-alpha image in Figure 4(A) of Ref.3 is similar to the Phospho-IkB-alpha image in Figure 5(A) of Ref.6 and the Phospho-IkBa image in Figure 3(A) of Ref.8 and the Phospho IkB-alpha image in Figure 6(A) of Ref.9.

(6)
The IkB-alpha image in Figure 4(B) of Ref.3 is similar to the IKB-alpha image in Figure 5(B) of Ref.6 and the IkBa image in Figure 3(B) of Ref.8 and the leftside 4 bands of the ONOO-IkB-alpha image in Figure 6(A) of Ref.9.

(7) The GST-Ikb-alpha image of top panel in Figure4(C) of Ref.1 is similar to both GST-Ikb-alpha image of top panel in Figure4(C) of Ref.3 and IkB-alpha image of top panel in Figure5(C) of Ref.6

(8) The IKKalpha/beta image in Figure 4(C) of Ref.3 is similar to both the ACC image in Figure 1(A) of Ref.6 and the IKKalpha/beta image in Figure 5(C) of Ref.6.

(9) The GST-Ikb-alpha image of bottom panel in Figure4(C) of Ref.3 is similar to GST-Ikb-alpha image of bottom panel in Figure4(C) of Ref.6. Moreover, these two images are similar to both the left-right reversal of the Akt image in Figure 1(A) of Ref.1 and the upside-down + left-right reversal of the GST-Ikb-alpha image of bottom panel in Figure4(C) of Ref.1

(10)
The GST-IkB-alpha image, bottom panel in Figure 4(C) of Ref.3 is similar to the Akt image in Figure 1(A) of Ref.6.

(11)
The left-side 4 bands (first to fourth bands from left) of the AMPK image in Figure 1(C) of Ref.3 is similar to the left-side 4 bands (first to fourth bands from left) of the AMPK image in Figure 2(A) of Ref.5.

(12)
The left-side 3 bands (first to third bands from left) of pAMPK image in Figure 1(C) of Ref.3 is similar to the left-side 3 bands (firtst to third bands from left) of pAPMK image in Figure 2(A) of Ref.5



__________________

References

1,
Metabolism. 2010 Jun 25. [Epub ahead of print] Fenofibrate suppresses microvascular inflammation and apoptosis through adenosine monophosphate-activated protein kinase activation.
Tomizawa A, Hattori Y, Inoue T, Hattori S, Kasai K.

2,
J Atheroscler Thromb. 2010;17(5):503-9.


3,
Cardiovasc Res. 2009 Jan 1;81(1):133-9.

4,
Hypertens Res. 2009 Sep;32(9):765-9.

5,
FEBS Lett. 2008 May 28;582(12):1719-24.

6,
Life Sci. 2008 Apr 9;82(15-16):884-91.

7,
Am J Hypertens. 2008 Apr;21(4):451-7.

8,
Hypertension. 2006 Jun;47(6):1183-8.

9,
Cardiovasc Res. 2004 Jul 1;63(1):31-40.
____


Sincerely yours,

Juuichi Jigen
E-mail: 11jigen@mail.goo.ne.jp




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申立てに対する科学雑誌編集者からの返信メール Part.3

2011年01月24日 | 科学雑誌編集者・出版社への申立て
・ 科学雑誌編集者・出版社への申立て
  申立てPart.1,  申立てPart.2,  申立てPart.3,  申立てPart.4
・ 申立てに対する、科学雑誌編集者・出版社からの返信メール
  返信Part.1返信Part.2返信Part.3



Journal Hypertension誌からの返信メール1

件名
R: Allegations of fabrication and falsification [J Hypertens. 2005 Jul;23(7):1375-82]
送信者
Journal Hypertension <j.hypertension@centroipertensione.191.it>
宛先
'Juuichi Jigen' <11jigen@mail.goo.ne.jp>
日時
2011年02月07日 22:54:56
Dear Doctor Jigen,

I have tekan note of the point raise against the authors of a paper published in the Journal of Hypertension more than five years ago, and - in your opinion - partly repeated in subsequent papers in other journals. Not having the original figure any longer (the paper was submitted before all manuscript had to be sent electronically), and obviously not having the originals of the figures published in other journals, I have some difficulty to safely recognize the "identity" of the figures. I also found you have discovered very late the alledged falsification.
In any case, since the publication on Journal of Hypertension was the first one in time, you may more properly address your complaints with the Editors of the journals that published the figures in question after the Journal of Hypertension.
Kind regards,

Prof. Alberto Zanchetti
Editor, Journal of Hypertension



-----Messaggio originale-----
Da: Juuichi Jigen [mailto:11jigen@mail.goo.ne.jp]
Inviato: giovedì 3 febbraio 2011 3.31
A: Phil.Daly@wolterskluwer.com; Magda.Lewandowska@wolterskluwer.com; j.hypertension@centroipertensione.191.it; alberto.zanchetti@unimi.it
Oggetto: Allegations of fabrication and falsification [J Hypertens. 2005 Jul;23(7):1375-82]

Please investigate fraudulent data of the article [Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress.
] by Kase H, Hashikabe Y, Uchida K, Nakanishi N, Hattori Y. published in J Hypertens. [2005 Jul;23(7):1375-82.]. You can find the fabricated (falsified) Figure 5(a) : namely, eNOS Western blot image in Figure 5(a) of the above article [J Hypertens. 2005 Jul;23(7):1375-82.] is identical to eNOS Western blot image in Figure 4 of another article [Eur J Pharmacol. 2007 Jan 19;555(1):48-53.] and MCP-1 Wstern blot image (left-right reversal) in Figure 4(B) of another article [Hypertension. 2006 Jun;47(6):1183-8.] .

Moreover, iNOS Protein Western blot images in Figure 5 of the above article [J Hypertens. 2005 Jul;23(7):1375-82.] is identical to iNOS Western blot image in Figure 4 of another article [Eur J Pharmacol. 2007 Jan 19;555(1):48-53.] and MCP-1 Western blot image in Figure 3(C) of another article [Life Sci. 2007 Aug 23;81(11):939-43.].



References
1
J Hypertens. 2005 Jul;23(7):1375-82.

2
Hypertension. 2006 Jun;47(6):1183-8. Epub 2006 Apr 24.

3
Eur J Pharmacol. 2007 Jan 19;555(1):48-53. Epub 2006 Oct 18.

4
Life Sci. 2007 Aug 23;81(11):939-43. Epub 2007 Aug 17.





Journal Hypertension誌からの返信メール2
件名
RE: Allegations of fabrication and falsification [J Hypertens. 2005 Jul;23(7):1375-82]
送信者
Daly, Phil <Phil.Daly@wolterskluwer.com>
宛先
Juuichi Jigen <11jigen@mail.goo.ne.jp> ; Lewandowska, Magda <Magda.Lewandowska@wolterskluwer.com> ; j.hypertension@centroipertensione.191.it ; alberto.zanchetti@unimi.it
日時
2011年02月08日 01:15:03
Dear Juuichi Jigen

Thank you for your e-mail. I am have difficulty opening your PDFs, but we will look for the material through other sources.

Yours sincerely

Phil Daly


Phil J. Daly, PhD
Senior Publisher
Wolters Kluwer Health Medical Research

Lippincott Williams & Wilkins
Ovid Technologies
250 Waterloo Road
London SE1 8RD
UK

Tel: 020 7981 0676
Int’l Tel: +44 20 7981 0676

E-mail: Phil.Daly@wolterskluwer.com

Confidentiality Notice: This email and its attachments (if any) contain confidential information of the sender. The information is intended only for the use by the direct addressees of the original sender of this email. If you are not an intended recipient of the original sender (or responsible for delivering the message to such person), you are hereby notified that any review, disclosure, copying, distribution or the taking of any action in reliance of the contents of and attachments to this email is strictly prohibited. If you have received this email in error, please immediately notify the sender at the address shown herein and permanently delete any copies of this email (digital or paper) in your possession.
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 Before printing this e-mail please make sure that it's necessary


-----Original Message-----
From: Juuichi Jigen [mailto:11jigen@mail.goo.ne.jp]
To: Daly, Phil; Lewandowska, Magda; j.hypertension@centroipertensione.191.it; alberto.zanchetti@unimi.it
Subject: Allegations of fabrication and falsification [J Hypertens. 2005 Jul;23(7):1375-82]

Please investigate fraudulent data of the article [Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress.
] by Kase H, Hashikabe Y, Uchida K, Nakanishi N, Hattori Y. published in J Hypertens. [2005 Jul;23(7):1375-82.]. You can find the fabricated (falsified) Figure 5(a) : namely, eNOS Western blot image in Figure 5(a) of the above article [J Hypertens. 2005 Jul;23(7):1375-82.] is identical to eNOS Western blot image in Figure 4 of another article [Eur J Pharmacol. 2007 Jan 19;555(1):48-53.] and MCP-1 Wstern blot image (left-right reversal) in Figure 4(B) of another article [Hypertension. 2006 Jun;47(6):1183-8.] .

Moreover, iNOS Protein Western blot images in Figure 5 of the above article [J Hypertens. 2005 Jul;23(7):1375-82.] is identical to iNOS Western blot image in Figure 4 of another article [Eur J Pharmacol. 2007 Jan 19;555(1):48-53.] and MCP-1 Western blot image in Figure 3(C) of another article [Life Sci. 2007 Aug 23;81(11):939-43.].



References
1
J Hypertens. 2005 Jul;23(7):1375-82.

2
Hypertension. 2006 Jun;47(6):1183-8. Epub 2006 Apr 24.

3
Eur J Pharmacol. 2007 Jan 19;555(1):48-53. Epub 2006 Oct 18.

4
Life Sci. 2007 Aug 23;81(11):939-43. Epub 2007 Aug 17.
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申立てに対する科学雑誌編集者からの返信メール Part.1

2011年01月24日 | 科学雑誌編集者・出版社への申立て
・ 科学雑誌編集者・出版社への申立て
  申立てPart.1,  申立てPart.2,  申立てPart.3,  申立てPart.4
・ 申立てに対する、科学雑誌編集者・出版社からの返信メール
  返信Part.1返信Part.2返信Part.3

American Journal of Hypertension誌からの返信メール
件名
RE: Allegations of fabrication and falsification (Am J Hypertens. 2008;21:451-7)
送信者
Yvonne P Raiford
宛先
Juuichi Jigen <11jigen@mail.goo.ne.jp>
日時
2011年02月04日 01:13:11
Dear Dr. Jigen,

Thank you for your letter. We are looking into this matter.

Best regards,

Yvonne Raiford
Managing Editor
American Journal of Hypertension

________________________________________
From: Juuichi Jigen [11jigen@mail.goo.ne.jp]
Sent: Thursday, February 03, 2011 5:22 AM
To: Yvonne P Raiford
Subject: Allegations of fabrication and falsification (Am J Hypertens. 2008;21:451-7)

Dear Dr.Raiford (Managing Editor of American Journal of Hypertension),


Please investigate fraudulent data of the article “Cilostazol activates AMP-activated protein kinase and restores endothelial function in diabetes.” By Suzuki K, Uchida K, Nakanishi N, Hattori Y., published in American Journal of Hypertension (2008 Apr;21(4):451-7.). You can find fabricated (falsified) Figure 1(a),(b) : namely,

(1)
The first, second and third bands from right of IkB-alpha image, top-panel in Figure 4(A) of Ref.2 is similar to the second, third and fourth bands from left of pAMPK image in Figure 1(A) of Ref.2.
Moreover, the first and second bands from left of IkB-alpha image, top-panel in Figure 4(A) of Ref.2 is similar to both the fifth and sixth bands from left of pAMPK image in Figure 1(A) of Ref.2
and the fifth and sixth bands from left of pAMPK image in Figure 1(a) of Ref.4..
Furthermore, the pAMPK image (all 7 bands) in Figure 1(A) of Ref.2 is similar to the pAMPK image (all 7 bands) in Figure 1(a) of Ref.4
,and first to sixth bands from left of the above pAMPK image of Ref.2,9 are similar to the pAMPK image for cilostazol in Figure 1(D) of Ref.2
and the pAMPK image in Figure 2(A) of Ref.1
and the pAMPK image for Metformin in Figure 3(b) of Ref.3.
In addition, the rightside 5 bands (2.5 min 〓 60 min) of the pAMPK imgae in Figure 2(A) of Ref.1 are similar to upside-down and left-right reversal of the pAMPK image in Figure 3(A) of Ref.1.

(2)
The AMPK image in Figure 1(A) of Ref.2 is similar to the APMK image in Figure 1(a) of Ref.4.
Moreover, the leftside 6 bands of these two APMK image are similar to the AMPK image in Figure 2(A) of Ref.1.
Furthermore, rightside 5 bands of this AMPK image in Figure 2(A) of Ref.1 are similar to the pAMPK image for Milrinone in Figure 1(D) of Ref.2


(3)
The rightside 5 bands of the AMPK image in Figure 1(B) of Ref.2 is similar to both the AMPK image in Figure 2(B) of Ref.1 and the AMPK image in Figure 1(b) of Ref.4.
Likewise, 5 bands (second to sixth bands from left) of pAMPK image in Figure 1(B) of Ref.2 are similar to the pAMPK image in Figure 2(B) of Ref.1 and the pAMPK image in Figure 1(b) of Ref.4.


(4)
The ACC and pACC images in Figure 1(A) of Ref.2 are similar to the ACC and pACC images in Figure 1(a) of Ref.4, respectively.
Moreover, the leftside 6 bands of these two images are similar to the ACC and p-ACC images in Figure 2(A) of Ref.1.


__________________

References

1,
J Atheroscler Thromb. 2010;17(5):503-9. Epub 2010 Feb 24.
Anti-inflammatory role of cilostazol in vascular smooth muscle cells in vitro and in vivo.
Aoki C, Hattori Y, Tomizawa A, Jojima T, Kasai K.


2,
Cardiovasc Res. 2009 Jan 1;81(1):133-9. Epub 2008 Aug 14.
Cilostazol inhibits cytokine-induced nuclear factor-kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells.
Hattori Y, Suzuki K, Tomizawa A, Hirama N, Okayasu T, Hattori S, Satoh H, Akimoto K, Kasai K.

3,
Hypertens Res. 2009 Sep;32(9):765-9. Epub 2009 Jul 10.
Telmisartan inhibits cytokine-induced nuclear factor-kappaB activation independently of the peroxisome proliferator-activated receptor-gamma.
Nakano A, Hattori Y, Aoki C, Jojima T, Kasai K.

4.
Am J Hypertens. 2008 Apr;21(4):451-7. Epub 2008 Feb 7.
Cilostazol activates AMP-activated protein kinase and restores endothelial function in diabetes.
Suzuki K, Uchida K, Nakanishi N, Hattori Y.



Sincerely yours,

Juuichi Jigen
E-mail: 11jigen@mail.goo.ne.jp




Life Sciences誌からの返信メール
件名
Re: Allegations of fabrication and falsification (Life Sciences 2008;82:884-91).
送信者
Frank Porreca
宛先
Juuichi Jigen <11jigen@mail.goo.ne.jp>
CC
Kanter-Schlifke, Irene (ELS-AMS) ; Kisthardt, Christine K - (kisthdt)
日時
2011年02月04日 00:44:29
Dear Dr. Jigen,

thank-you for bringing this to our attention. We will investigate
this and be back in touch shortly.

Sincerely,

Frank Porreca

At 01:10 AM 2/3/2011, you wrote:
>Dear Dr. Porreca,
>
>Please investigate fraudulent data of the article $B!H(BPPARalpha
>activators upregulate eNOS activity and inhibit cytokine-induced
>NF-kappaB activation through AMP-activated protein kinase
>activation.$B!I(B Okayasu T, Tomizawa A, Suzuki K, Manaka K, Hattori
>Y., published in Life Sciences (2008 Apr 9;82(15-16):884-91). You
>can find fabricated (falsified) Figure 1(A),(B) and Figure
>5(A),(B),(C) : namely,
>
>(1)
>The Phospho-IkB-alpha image in Figure 4(A) of Ref.2 is similar to
>the Phospho-IkB-alpha image in Figure 5(A) of Ref.3
>and the Phospho-IkBa image in Figure 3(A) of Ref.4
>and the Phospho IkB-alpha image in Figure 6(A) of Ref.5.
>
>(2)
>The IkB-alpha image in Figure 4(B) of Ref.2 is similar to
>the IKB-alpha image in Figure 5(B) of Ref.3
>and the IkBa image in Figure 3(B) of Ref.4
>and the leftside 4 bands of the ONOO-IkB-alpha image in Figure 6(A) of Ref.5.
>
>(3)
>The GST-Ikb-alpha image of top panel in Figure 4(C) of Ref.1 is
>similar to both GST-Ikb-alpha image of top panel in Figure4(C) of
>Ref.2 and IkB-alpha image of top panel in Figure 5(C) of Ref.3
>
>
>(4)
>The IKKalpha/beta image in Figure 4(C) of Ref.2 is similar to both
>the ACC image in Figure 1(A) of Ref.3 and the IKKalpha/beta image in
>Figure 5(C) of Ref.3.
>
>(5)
>The GST-Ikb-alpha image of bottom panel in Figure 4(C) of Ref.2 is
>similar to GST-Ikb-alpha image of bottom panel in Figure4(C) of
>Ref.3. Moreover, these two images are similar to both the left-right
>reversal of the Akt image in Figure 1(A) of Ref.1 and the
>upside-down + left-right reversal of the GST-Ikb-alpha image of
>bottom panel in Figure4(C) of Ref.1
>
>(6)
>The GST-IkB-alpha image, bottom panel in Figure 4(C) of Ref.2 is
>similar to the Akt image in Figure 1(A) of Ref.3.
>
>(7)
>The p-AKT image in Figure 1(A) of Ref.3 is similar to the p-ACC
>image in Figure 1(B) of Ref.3
>
>(8)
>The IkB-alpha image in Figure 5(A) of Ref.3 is similar to both the
>IkB-a image in Figure 3(A) of Ref.4 and the IkB-alpha image in
>Figure 6(A) of Ref.5.
>
>(9)
>The AMPK and pAMPK images in Figure 1(A) of Ref.1 are similar to the
>AMPK and pAMPK images in Figure 1(A) of Ref.3.
>
>(10)
>The p-AKT image in Figure 1(A) of Ref.1 is similar to the p-Akt
>image in Figure 1(A) of Ref.3.
>
>(11)
>The eNOS image in Figure 1(A) of Ref.1 is similar to the eNOS image
>in Figure 1(A) of Ref.3.
>
>
>
>__________________
>
>References
>
>1,
>Metabolism. 2010 Jun 25. [Epub ahead of print]
>Fenofibrate suppresses microvascular inflammation and apoptosis
>through adenosine monophosphate-activated protein kinase activation.
>Tomizawa A, Hattori Y, Inoue T, Hattori S, Kasai K.
>
>2,
>Cardiovasc Res. 2009 Jan 1;81(1):133-9. Epub 2008 Aug 14.
>Cilostazol inhibits cytokine-induced nuclear factor-kappaB
>activation via AMP-activated protein kinase activation in vascular
>endothelial cells.
>Hattori Y, Suzuki K, Tomizawa A, Hirama N, Okayasu T, Hattori S,
>Satoh H, Akimoto K, Kasai K.
>
>3,
>Life Sci. 2008 Apr 9;82(15-16):884-91. Epub 2008 Feb 16.
>PPARalpha activators upregulate eNOS activity and inhibit
>cytokine-induced NF-kappaB activation through AMP-activated protein
>kinase activation.
>Okayasu T, Tomizawa A, Suzuki K, Manaka K, Hattori Y.
>
>
>4,
>Hypertension. 2006 Jun;47(6):1183-8. Epub 2006 Apr 24.
>Metformin inhibits cytokine-induced nuclear factor kappaB activation
>via AMP-activated protein kinase activation in vascular endothelial cells.
>Hattori Y, Suzuki K, Hattori S, Kasai K.
>
>
>5,
>Cardiovasc Res. 2004 Jul 1;63(1):31-40.
>NO suppresses while peroxynitrite sustains NF-kappaB: a paradigm to
>rationalize cytoprotective and cytotoxic actions attributed to NO.
>Hattori Y, Kasai K, Gross SS.
>
>
>
>Sincerely yours,
>
>Juuichi Jigen
>E-mail: 11jigen@mail.goo.ne.jp
>
>
>
>
>




Biochimica et Biophysica Acta誌からの返信メール

件名
Re: Allegations of fabrication and falsification
送信者
Dennis Vance
宛先
Juuichi Jigen <11jigen@mail.goo.ne.jp>
CC
Jeffrey Keller ; Adriaan FA (ELS-AMS) Klinkenberg
日時
2011年02月03日 01:35:29
添付
J Cardiovasc Pharmacol. 2004 43 209-13.pdf (583k)attach1 (1k)
Dear Dr. Jigen:
Thanks for your email. I have looked at the two figures and agree that the top panels in the two Figures seem to be identical but I am not so sure the bottom panels are the same. I shall write to Dr. Hattori and ask for an explanation. I will let you know his reply and any action we might take.
Sincerely yours,

Dennis Vance, PhD
Distinguished University Professor
Editor-in-Chief, BBA
Scientist of the Alberta Heritage Foundation for Medical Research
Chair, Board of Directors, Deuel Conference on Lipids

Department of Biochemistry and Group on the Molecular and Cell Biology of Lipids
School of Molecular and Systems Medicine
328 Heritage Medical Research Centre
University of Alberta
Edmonton, Alberta T6G 2S2 Canada

phone: 780-492-8286
Fax: 780-492-3383
email: dennis.vance@ualberta.ca





Journal of Cardiovascular Pharmacology誌からの返信メール

件名
Re: RE: Allegations of fabrication and falsification
送信者
Juuichi Jigen <11jigen@mail.goo.ne.jp>
宛先
Emily.Hurd@wolterskluwer.com
添付
BBA2004.pdf (613k)JCP2004.pdf (583k)
Dear Dr. Hurd,

I am sorry for your inconvenience.
Now, I send new attachments.
Please compare Figure 3's top panel of JCP2004 article and Figure 5's top panel of BBA2004 article.
Sincerely yours,


Juuichi Jigen




----- Original Message -----

> Dear Dr. Jigen:
>
> We are not able to open the files attached to this email either. Please
> send new attachments.
>
> Kind Regards,
> Emily Hurd
>
> Emily Hurd
> Managing Editor, Journal of Cardiovascular Pharmacology
> Wolters Kluwer Health Medical Research
>
> tel (978) 979-1111
> emily.hurd@wolterskluwer.com
>
> Confidentiality Notice: This email and its attachments (if any) contain
> confidential information of the sender. The information is intended only
> for the use by the direct addressees of the original sender of this
> email. If you are not an intended recipient of the original sender (or
> responsible for delivering the message to such person), you are hereby
> notified that any review, disclosure, copying, distribution or the
> taking of any action in reliance of the contents of and attachments to
> this email is strictly prohibited. If you have received this email in
> error, please immediately notify the sender at the address shown herein
> and permanently delete any copies of this email (digital or paper) in
> your possession.
>
>
> -----Original Message-----
> From: Juuichi Jigen [mailto:11jigen@mail.goo.ne.jp]
> Sent: Wednesday, February 02, 2011 9:28 AM
> To: Hurd, Emily; Sollenberger, Jennifer; Hee, Laurie
> Subject: Allegations of fabrication and falsification
>
> Please investigate fraudulent data of the article "Disruption of the
> actin cytoskeleton up-regulates iNOS expression in vascular smooth
> muscle cells." by Hattori Y, Kasai K. published in J Cardiovasc
> Pharmacol. (2004 Feb;43(2):209-13.). You can find the fabricated
> (falsified) Figure 3 : namely, Figure 3 of the above article [J
> Cardiovasc Pharmacol. (2004 Feb;43(2):209-13.)] is identical to Figure 5
> of another article [Biochim Biophys Acta. (2004 Aug 4;1689(3):267-72.)].
>
>
> References
> 1
> J Cardiovasc Pharmacol. 2004 Feb;43(2):209-13.
> Disruption of the actin cytoskeleton up-regulates iNOS expression in
> vascular smooth muscle cells.
> Hattori Y, Kasai K.
> http://www.ncbi.nlm.nih.gov/pubmed/14716207
>
> 2
> Biochim Biophys Acta. 2004 Aug 4;1689(3):267-72.
> Statin blocks Rho/Rho-kinase signalling and disrupts the actin
> cytoskeleton: relationship to enhancement of LPS-mediated nitric oxide
> synthesis in vascular smooth muscle cells.
> Kato T, Hashikabe H, Iwata C, Akimoto K, Hattori Y.
>







Diabetes, Obesity and Metabolism誌からの返信メール
件名
FW: Diab. Obes. Metab. 2009; 11: 143-149
送信者
Susan Lane
宛先
11jigen@mail.goo.ne.jp
日時
2011年02月03日 23:11:21
From: Richard Donnelly [mailto:Richard.Donnelly@nottingham.ac.uk]
Sent: 03 February 2011 11:04
To: 11jigen@mail.goo.n.ejp
Cc: Susan Lane
Subject: Diab. Obes. Metab. 2009; 11: 143-149

Dear Dr Jigen:

Thank you for your Email concerning a paper published by Jojima et al in Diab. Obes. Metab.

Research misconduct is something that concerns all of us, but the responsibility for investigating allegations of research misconduct lies with the university that employs the authors and any sponsor that funded the research. Most, if not all, universities have clear internal policies and procedures for investigating allegations of research misconduct.

You should, therefore, direct your concerns to the relevant Dean or principal of Dokkyo University School of Medicine. If the institution, as part of their investigation, requires information from the Journal, I will be happy to assist. Furthermore, the journal would take appropriate action only on the advice of an institutional committee or head, following the conclusion of their internal investigation.

Sincerely:


Prof. Richard Donnelly MD, PhD, FRCP, FRACP
Editor, Diabetes, Obesilty and Metabolism



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論文捏造についての科学雑誌編集者・出版社への申立て Part.3

2011年01月24日 | 科学雑誌編集者・出版社への申立て
・ 科学雑誌編集者・出版社への申立て
  申立てPart.1,  申立てPart.2,  申立てPart.3,  申立てPart.4
・ 申立てに対する、科学雑誌編集者・出版社からの返信メール
  返信Part.1返信Part.2返信Part.3



Cardiovasc Res誌への申立て
------------------------------------------------------------
Comments sent via CARDIOVASC RES Feedback Page

COMMENTS:
Dear Dr. Hans Michael Piper,


Please investigate fraudulent data of the article “Cilostazol inhibits cytokine-induced nuclear factor-kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells.” Hattori Y, Suzuki K, Tomizawa A, Hirama N, Okayasu T, Hattori S, Satoh H, Akimoto K, Kasai K., published in Cardiovasc Research (2009,81,133-9). You can find fabricated (falsified) Fig. 1(A),(B),(C),(D) and Fig.4(A),(B),(C) : namely,

(1)
The first, second and third bands from right of IkB-alpha image, top-panel in Fig. 4(A) of Ref.3 is similar to the second, third and fourth bands from left of pAMPK image in Fig. 1(A) of Ref.3.
Moreover, the first and second bands from left of IkB-alpha image, top-panel in Fig. 4(A) of Ref.3 is similar to both the fifth and sixth bands from left of pAMPK image in Fig. 1(A) of Ref.3
and the fifth and sixth bands from left of pAMPK image in Fig. 1(a) of Ref.7.
Furthermore, the pAMPK image (all 7 bands) in Fig. 1(A) of Ref.3 is similar to the pAMPK image (all 7 bands) in Fig. 1(a) of Ref.7
,and first to sixth bands from left of the above pAMPK image of Ref.3,9 are similar to the pAMPK image for cilostazol in Fig. 1(D) of Ref.3
and the pAMPK image in Fig. 2(A) of Ref.2
and the pAMPK image for Metformin in Fig. 3(b) of Ref.4.
In addition, the rightside 5 bands (2.5 min – 60 min) of the pAMPK imgae in Fig. 2(A) of Ref.2 are similar to upside-down and left-right reversal of the pAMPK image in Fig. 3(A) of Ref.2.

(2)
The AMPK image in Fig. 1(A) of Ref.3 is similar to the APMK image in Fig. 1(a) of Ref.7.
Moreover, the leftside 6 bands of these two APMK image are similar to the AMPK image in Fig. 2(A) of Ref.2.
Furthermore, rightside 5 bands of this AMPK image in Fig. 2(A) of Ref.2 are similar to the pAMPK image for Milrinone in Fig. 1(D) of Ref.3


(3)
The rightside 5 bands of the AMPK image in Fig. 1(B) of Ref.3 is similar to both the AMPK image in Fig. 2(B) of Ref.2 and the AMPK image in Fig. 1(b) of Ref.7.
Likewise, 5 bands (second to sixth bands from left) of pAMPK image in Fig. 1(B) of Ref.3 are similar to the pAMPK image in Fig. 2(B) of Ref.2 and the pAMPK image in Fig. 1(b) of Ref.7.

(4)
The ACC and pACC images in Fig. 1(A) of Ref.3 are similar to the ACC and pACC images in Fig. 1(a) of Ref.7, respectively.
Moreover, the leftside 6 bands of these two images are similar to the ACC and p-ACC images in Fig. 2(A) of Ref.2.

(5)
The Phospho-IkB-alpha image in Fig. 4(A) of Ref.3 is similar to
the Phospho-IkB-alpha image in Fig. 5(A) of Ref.6
and the Phospho-IkBa image in Fig. 3(A) of Ref.8
and the Phospho IkB-alpha image in Fig. 6(A) of Ref.9.

(6)
The IkB-alpha image in Fig. 4(B) of Ref.3 is similar to
the IKB-alpha image in Fig. 5(B) of Ref.6
and the IkBa image in Fig. 3(B) of Ref.8
and the leftside 4 bands of the ONOO-IkB-alpha image in Fig. 6(A) of Ref.9.

(7) The GST-Ikb-alpha image of top panel in Fig.4(C) of Ref.1 is similar to both GST-Ikb-alpha image of top panel in Fig.4(C) of Ref.3 and IkB-alpha image of top panel in Fig.5(C) of Ref.6

(8) The IKKalpha/beta image in Fig. 4(C) of Ref.3 is similar to both the ACC image in Fig. 1(A) of Ref.6 and the IKKalpha/beta image in Fig. 5(C) of Ref.6.

(9) The GST-Ikb-alpha image of bottom panel in Fig.4(C) of Ref.3 is similar to GST-Ikb-alpha image of bottom panel in Fig.4(C) of Ref.6. Moreover, these two images are similar to both the left-right reversal of the Akt image in Fig. 1(A) of Ref.1 and the upside-down + left-right reversal of the GST-Ikb-alpha image of bottom panel in Fig.4(C) of Ref.1

(10)
The GST-IkB-alpha image, bottom panel in Fig. 4(C) of Ref.3 is similar to the Akt image in Fig. 1(A) of Ref.6.

(11)
The left-side 4 bands (first to fourth bands from left) of the AMPK image in Fig. 1(C) of Ref.3 is similar to the left-side 4 bands (first to fourth bands from left) of the AMPK image in Fig. 2(A) of Ref.5.

(12)
The left-side 3 bands (first to third bands from left) of pAMPK image in Fig. 1(C) of Ref.3 is similar to the left-side 3 bands (firtst to third bands from left) of pAPMK image in Fig. 2(A) of Ref.5



__________________

References

1,
Metabolism. 2010 Jun 25. [Epub ahead of print]

2,
J Atheroscler Thromb. 2010;17(5):503-9.

3,
Cardiovasc Res. 2009 Jan 1;81(1):133-9.

4,
Hypertens Res. 2009 Sep;32(9):765-9.

5,
FEBS Lett. 2008 May 28;582(12):1719-24.

6,
Life Sci. 2008 Apr 9;82(15-16):884-91.

7,
Am J Hypertens. 2008 Apr;21(4):451-7.

8,
Hypertension. 2006 Jun;47(6):1183-8.

9,
Cardiovasc Res. 2004 Jul 1;63(1):31-40.






J Hypertension誌への申立て
件名
Allegations of fabrication and falsification [J Hypertens. 2005 Jul;23(7):1375-82]
宛先
Phil.Daly@wolterskluwer.com ; Magda.Lewandowska@wolterskluwer.com ; j.hypertension@centroipertensione.191.it ; alberto.zanchett


Please investigate fraudulent data of the article [Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress.
] by Kase H, Hashikabe Y, Uchida K, Nakanishi N, Hattori Y. published in J Hypertens. [2005 Jul;23(7):1375-82.]. You can find the fabricated (falsified) Fig. 5(a) : namely, eNOS Western blot image in Fig. 5(a) of the above article [J Hypertens. 2005 Jul;23(7):1375-82.] is identical to eNOS Western blot image in Fig. 4 of another article [Eur J Pharmacol. 2007 Jan 19;555(1):48-53.] and MCP-1 Wstern blot image (left-right reversal) in Fig. 4(B) of another article [Hypertension. 2006 Jun;47(6):1183-8.] .

Moreover, iNOS Protein Western blot images in Fig. 5 of the above article [J Hypertens. 2005 Jul;23(7):1375-82.] is identical to iNOS Western blot image in Fig. 4 of another article [Eur J Pharmacol. 2007 Jan 19;555(1):48-53.] and MCP-1 Western blot image in Fig. 3(C) of another article [Life Sci. 2007 Aug 23;81(11):939-43.].



References
1
J Hypertens. 2005 Jul;23(7):1375-82.

2
Hypertension. 2006 Jun;47(6):1183-8.

3
Eur J Pharmacol. 2007 Jan 19;555(1):48-53.

4
Life Sci. 2007 Aug 23;81(11):939-43.







Metabolism誌への申立て

件名
Allegations of fabrication and falsification [Metabolism. 2010 Jun 25. [Epub ahead of print]
宛先
metabolism@elsevier.com
CC
andrew.miller@elsevier.com


Dear Dr.Mantzoros,

Please investigate fraudulent data of the article “Fenofibrate suppresses microvascular inflammation and apoptosis through adenosine monophosphate-activated protein kinase activation.” by Tomizawa A, Hattori Y, Inoue T, Hattori S, Kasai K., published in


Metabolism Clinical and Experimental (2010 Jun 25. [Epub ahead of print]). You can find fabricated (falsified) Fig. 1(A) and 4(A),(B),(C) : namely,

(1) The GST-Ikb-alpha image of top panel in Fig.4(C) of the above article (Ref.1) is quite similar to both GST-Ikb-alpha image of top panel in Fig.4(C) of another article (Ref.2) and Ikb-alpha image of top panel in Fig.5(C) of another article (Ref.4)
(2) The GST-Ikb-alpha image of bottom panel in Fig.4(C) of Ref.2 is quite similar to GST-Ikb-alpha image of bottom panel in Fig.4(C) of Ref.4. Moreover, these two images are quite similar to both the left-right reversal of the Akt image in Fig. 1(A) of Ref.1 and the upside-down + left-right reversal of the GST-Ikb-alpha image of bottom panel in Fig.4(C) of Ref.1
(3) The AMPK image and pAMPK image in Fig.1(A) of Ref.1 are similar to the AMPK image and pAMPK image in Fig.1(A) of Ref.4, respectively.
(4) The p-Akt image in Fig.1(A) of Ref.1 is similar to the p-Akt image in Fig.1(A) of Ref.4.
(5) The eNOS image in Fig.1(A) of Ref.1 is similar to the left-right reversal of eNOS image in Fig.1(A) of Ref.4.
(6) The leftmost band (for 0 min) of IkB-alpha image, top-panel in Fig.4(A) of Ref.1 is similar to leftmost band of GST-IkB-alpha image, bottom-panel in Fig.4(C) of Ref.1.
(7) The second, third and forth bands from left (15,30,60 min) of IkB-alpha image, top-panel in Fig.4(A) of Ref.1 is similar to the second, third and forth bands from left (for 0, 30, 100 uM fenofibrate) of IkB-alpha image in Fig.4(B) of Ref.1. Moreover, these two images are similar to the first, second and third bands from left (for 0, 5, 15 min) of p-Akt image, top-panel in Fig.2(B) of Ref.3
(8) The leftmost band (for Cont) of IkB-alpha image in Fig.4(A) of Ref.1 is similar to the forth band (for 30 min) from left of pAkt image, top-panel in Fig.2(B) of Ref.3



References

1,
Metabolism. 2010 Jun 25. [Epub ahead of print]

2,
Cardiovasc Res. 2009 Jan 1;81(1):133-9.

3
Diabetes Obes Metab. 2009 Feb;11(2):143-9.

4
Life Sci. 2008 Apr 9;82(15-16):884-91.





Diabetes Obes Metab誌への申立て

件名
Allegations of fabrication and falsification (Diabetes Obes Metab. 2009 11:143-9)
宛先
susan.lane@nottingham.ac.uk
CC
jdom@bcm.tmc.edu



Dear Dr. Donnelly,

Please investigate fraudulent data of the article “Glimepiride upregulates eNOS activity and inhibits cytokine-induced NF-kappaB activation through a phosphoinoside 3-kinase-Akt-dependent pathway.” by Jojima T, Suzuki K, Hirama N, Uchida K, Hattori Y., published in
Diabetes, Obesity and Metabolism (2009 Feb;11(2):143-9). You can find fabricated (falsified) Figure 2(B) : namely,

(1) The first, second and third bands from left (for 0, 5, 15 min) of p-Akt image, top-panel in Figure2(B) of the above article (Ref.3) are similar to both the second, third and forth bands from left (15,30,60 min) of IkB-alpha image, top-panel in Figure4(A) of Ref.1 and the second, third and forth bands from left (for 0, 30, 100 uM fenofibrate) of IkB-alpha image in Figure4(B) of Ref.1.
(2) The forth band (for 30 min) from left of pAkt image, top-panel in Figure2(B) of the above article (Ref.3)is similar to The leftmost band (for Cont) of IkB-alpha image in Figure4(A) of Ref.1

________Other misconducts by these author_____________
(I) The GST-Ikb-alpha image of top panel in Figure4(C) of the above article (Ref.1) is quite similar to both GST-Ikb-alpha image of top panel in Figure4(C) of another article (Ref.2) and Ikb-alpha image of top panel in Figure5(C) of another article (Ref.4)

(II) The GST-Ikb-alpha image of bottom panel in Figure4(C) of Ref.2 is quite similar to GST-Ikb-alpha image of bottom panel in Figure4(C) of Ref.4. Moreover, these two images are quite similar to both the left-right reversal of the Akt image in Figure 1(A) of Ref.1 and the upside-down + left-right reversal of the GST-Ikb-alpha image of bottom panel in Figure4(C) of Ref.1

(III) The AMPK image and pAMPK image in Figure1(A) of Ref.1 are similar to the AMPK image and pAMPK image in Figure1(A) of Ref.4, respectively.

(IV) The p-Akt image in Figure1(A) of Ref.1 is similar to the p-Akt image in Figure1(A) of Ref.4.

(V) The eNOS image in Figure1(A) of Ref.1 is similar to the left-right reversal of eNOS image in Figure1(A) of Ref.4.

(VI) The leftmost band (for 0 min) of IkB-alpha image, top-panel in Figure4(A) of Ref.1 is similar to the leftmost band of GST-IkB-alpha image, bottom-panel in Figure4(C) of Ref.1.



References
1,
Metabolism. 2010 Jun 25. [Epub ahead of print]


2,
Cardiovasc Res. 2009 Jan 1;81(1):133-9. Epub 2008 Aug 14.


3
Diabetes Obes Metab. 2009 Feb;11(2):143-9. Epub 2008 Jun 16.


4
Life Sci. 2008 Apr 9;82(15-16):884-91. Epub 2008 Feb 16.



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論文捏造についての科学雑誌編集者・出版社への申立て Part.2

2011年01月24日 | 科学雑誌編集者・出版社への申立て
・ 科学雑誌編集者・出版社への申立て
  申立てPart.1,  申立てPart.2,  申立てPart.3,  申立てPart.4
・ 申立てに対する、科学雑誌編集者・出版社からの返信メール
  返信Part.1返信Part.2返信Part.3



Life Sciences誌への申立て

件名
Allegations of fabrication and falsification (Life Sciences 2008;82:884-91).
宛先
frankp@email.arizona.edu


Please investigate fraudulent data of the article “PPARalpha activators upregulate eNOS activity and inhibit cytokine-induced NF-kappaB activation through AMP-activated protein kinase activation.” Okayasu T, Tomizawa A, Suzuki K, Manaka K, Hattori Y., published in Life Sciences (2008;82,884-91). You can find fabricated (falsified) Fig. 1(A),(B) and Fig. 5(A),(B),(C) : namely,

(1)
The Phospho-IkB-alpha image in Fig. 4(A) of Ref.2 is similar to
the Phospho-IkB-alpha image in Fig. 5(A) of Ref.3
and the Phospho-IkBa image in Fig. 3(A) of Ref.4
and the Phospho IkB-alpha image in Fig. 6(A) of Ref.5.

(2)
The IkB-alpha image in Fig. 4(B) of Ref.2 is similar to
the IKB-alpha image in Fig. 5(B) of Ref.3
and the IkBa image in Fig. 3(B) of Ref.4
and the leftside 4 bands of the ONOO-IkB-alpha image in Fig. 6(A) of Ref.5.

(3)
The GST-Ikb-alpha image of top panel in Fig. 4(C) of Ref.1 is similar to both GST-Ikb-alpha image of top panel in Fig.4(C) of Ref.2 and IkB-alpha image of top panel in Fig. 5(C) of Ref.3


(4)
The IKKalpha/beta image in Fig. 4(C) of Ref.2 is similar to both the ACC image in Fig. 1(A) of Ref.3 and the IKKalpha/beta image in Fig. 5(C) of Ref.3.

(5)
The GST-Ikb-alpha image of bottom panel in Fig. 4(C) of Ref.2 is similar to GST-Ikb-alpha image of bottom panel in Fig.4(C) of Ref.3. Moreover, these two images are similar to both the left-right reversal of the Akt image in Fig. 1(A) of Ref.1 and the upside-down + left-right reversal of the GST-Ikb-alpha image of bottom panel in Fig.4(C) of Ref.1

(6)
The GST-IkB-alpha image, bottom panel in Fig. 4(C) of Ref.2 is similar to the Akt image in Fig. 1(A) of Ref.3.

(7)
The p-AKT image in Fig. 1(A) of Ref.3 is similar to the p-ACC image in Fig. 1(B) of Ref.3

(8)
The IkB-alpha image in Fig. 5(A) of Ref.3 is similar to both the IkB-a image in Fig. 3(A) of Ref.4 and the IkB-alpha image in Fig. 6(A) of Ref.5.

(9)
The AMPK and pAMPK images in Fig. 1(A) of Ref.1 are similar to the AMPK and pAMPK images in Fig. 1(A) of Ref.3.

(10)
The p-AKT image in Fig. 1(A) of Ref.1 is similar to the p-Akt image in Fig. 1(A) of Ref.3.

(11)
The eNOS image in Fig. 1(A) of Ref.1 is similar to the eNOS image in Fig. 1(A) of Ref.3.





References

1,
Metabolism. 2010 Jun 25. [Epub ahead of print]
Fenofibrate suppresses microvascular inflammation and apoptosis through adenosine monophosphate-activated protein kinase activation.
Tomizawa A, Hattori Y, Inoue T, Hattori S, Kasai K.

2,
Cardiovasc Res. 2009 Jan 1;81(1):133-9.

3,
Life Sci. 2008 Apr 9;82(15-16):884-91.

4,
Hypertension. 2006 Jun;47(6):1183-8.

5,
Cardiovasc Res. 2004 Jul 1;63(1):31-40.






Hypertension誌への申立て

件名
Allegations of fabrication and falsification (Hypertension 2006 Jun;47(6):1183-8.)
宛先
hypertension@physiology.umsmed.edu ; jehall@physiology.umsmed.edu
CC
hypertension@umc.edu


Dear Dr.John E. Hall, Editor-in-Chief of Hypertension,


Please investigate fraudulent data of the article “Metformin inhibits Cytokine-Induced NF-kB Activation via AMPK Activation in Vascular Endothelial Cells” Hattori Y, Suzuki K, Hattori S, Kasai K., published in Hypertension (2006 Jun;47(6):1183-8.). You can find fabricated (falsified) Fig. 3(A),(B),(C) and Fig. 4(B) : namely,

(1)
The Phospho-IkB-alpha image in Fig. 4(A) of Ref.1 is similar to
the Phospho-IkB-alpha image in Fig. 5(A) of Ref.2
and the Phospho-IkBa image in Fig. 3(A) of Ref.4
and the Phospho IkB-alpha image in Fig. 6(A) of Ref.6.

(2)
The IkB-alpha image in Fig. 4(B) of Ref.1 is similar to
the IKB-alpha image in Fig. 5(B) of Ref.2
and the IkBa image in Fig. 3(B) of Ref.4
and the leftside 4 bands of the ONOO-IkB-alpha image in Fig. 6(A) of Ref.6.

(3)
The IkB-alpha image in Fig. 5(A) of Ref.2 is similar to both the IkB-a image in Fig. 3(A) of Ref.4 and the IkB-alpha image in Fig. 6(A) of Ref.6.


(4)
The right-side 3 bands (second, third and fourth bands from left) of IkB-alpha image, top-panel in Fig. 3(C) of Ref.4 is similar to the middle 3 bands (second, third and fourth bands from left) of IkB-alpha image, top-panel in Fig. 6(B) of Ref.6.

(5)
The IKKa/b image in Fig. 3(C) of Ref.4 is similar to the left-side 4 bands (first to fourth bands from left) of the IKKalpha/beta image, fifth panel from bottom in Fig. 6(B) of Ref.6.
Moreover, the left-side 3 bands of these two images are similar to the IKKalpha/beta image, second panel from bottom in Fig. 6(B) of Ref.6.

(6)
The IkB-a image, bottom panel in Fig. 3(C) of Ref.4 is similar to the left-side 4 bands (first to fourth bands from left) of IkB-alpha image, fourth panel from bottom in Fig. 6(B) of Ref.6.
Moreover, the left-side 3 bands of these image are similar to the IkB-alpha image, bottom panel in Fig. 6(B) of Ref.6.

(7)
The eNOS image in Fig. 4(A) of Ref.3 is similar to the right-side 6 bands (for BH4 only, AngII, AngII/BH4) of eNOS Protein image in Fig. 5(a) of Ref.5.
Moreover, these two images are similar to the 6 bands (third to eighth bands from left) of the MCP-1 image in Fig. 4(B) of Ref.4.



References

1
Cardiovasc Res. 2009 Jan 1;81(1):133-9.

2,
Life Sci. 2008 Apr 9;82(15-16):884-91.

3,
Eur J Pharmacol. 2007 Jan 19;555(1):48-53.

4,
Hypertension. 2006 Jun;47(6):1183-8.

5
J Hypertens. 2005 Jul;23(7):1375-82.

6
Cardiovasc Res. 2004 Jul 1;63(1):31-40.






Cardiovasc Research誌への申立て
件名
Allegations of fabrication and falsification (Cardiovasc Research 2004 Jul 1;63(1):31-40)
宛先
CVR@physiologie.med.uni-giessen.de

Dear Dr. Hans Michael Piper,


Please investigate fraudulent data of the article “NO suppresses while peroxynitrite sustains NF-kB: A paradigm to rationalize cytoprotective and cytotoxic actions attributed to NO” Hattori Y, Kasai K, Gross SS, published in Cardiovascular Research. (2004 Jul 1;63(1):31-40.). You can find fabricated (falsified) Fig. 6(A),(B) : namely,

(1)
The Phospho-IkB-alpha image in Fig. 4(A) of Ref.1 is similar to
the Phospho-IkB-alpha image in Fig. 5(A) of Ref.2
and the Phospho-IkBa image in Fig. 3(A) of Ref.3
and the Phospho IkB-alpha image in Fig. 6(A) of Ref.4.

(2)
The IkB-alpha image in Fig. 4(B) of Ref.1 is similar to
the IKB-alpha image in Fig. 5(B) of Ref.2
and the IkBa image in Fig. 3(B) of Ref.3
and the leftside 4 bands of the ONOO-IkB-alpha image in Fig. 6(A) of Ref.4.

(3)
The IkB-alpha image in Fig. 5(A) of Ref.2 is similar to both the IkB-a image in Fig. 3(A) of Ref.3 and the IkB-alpha image in Fig. 6(A) of Ref.4.

(4)
The right-side 3 bands (second, third and fourth bands from left) of IkB-alpha image, top-panel in Fig. 3(C) of Ref.3 is similar to the middle 3 bands (second, third and fourth bands from left) of IkB-alpha image, top-panel in Fig. 6(B) of Ref.4.

(5)
The second band from left of IkB-alpha image, top-panel in Fig. 6(B) of Ref.4 is similar to the second band from left of IkB-alpha image, third panel from bottom in Fig. 6(B) of Ref.4.

(6)
The IKKa/b image in Fig. 3(C) of Ref.3 is similar to the left-side 4 bands (first to fourth bands from left) of the IKKalpha/beta image, fifth panel from bottom in Fig. 6(B) of Ref.4.
Moreover, the left-side 3 bands of these two images are similar to the IKKalpha/beta image, second panel from bottom in Fig. 6(B) of Ref.4.

(7)
The IkB-a image, bottom panel in Fig. 3(C) of Ref.3 is similar to the left-side 4 bands (first to fourth bands from left) of IkB-alpha image, fourth panel from bottom in Fig. 6(B) of Ref.4.
Moreover, the left-side 3 bands of these image are similar to the IkB-alpha image, bottom panel in Fig. 6(B) of Ref.4.

(8)
The left-side 3 bands (first, second and third bands from left) of NOR3 IkB-alpha image in Fig. 6(A) of Ref.4 is similar to the right-side 3 bands (third, fourth and fifth bands from left) of IKKalpha/beta image, fifth panel from bottom in Fig. 6(B) of Ref.4.




References

1
Cardiovasc Res. 2009 Jan 1;81(1):133-9.

2,
Life Sci. 2008 Apr 9;82(15-16):884-91.

3,
Hypertension. 2006 Jun;47(6):1183-8.

4,
Cardiovasc Res. 2004 Jul 1;63(1):31-40.








JAT誌への申立て
件名
Allegations of fabrication and falsification (JAT Vol. 17 (2010) , No. 5 503-509.).
宛先
shinichi@nms.ac.jp
CC
jas@kk-kyowa.co.jp


Please investigate fraudulent data of the article “Anti-inflammatory role of cilostazol in vascular smooth muscle cells in vitro and in vivo.” Aoki C, Hattori Y, Tomizawa A, Jojima T, Kasai K., published in Journal of Atherosclerosis and Thrombosis. (Vol. 17 (2010) , No. 5 503-509.). You can find fabricated (falsified) Fig. 2(A),(B) and 3(A) : namely,

(1)
The first, second and third bands from right of IkB-alpha image, top-panel in Fig. 4(A) of Ref.2 is similar to the second, third and fourth bands from left of pAMPK image in Fig. 1(A) of Ref.2.
Moreover, the first and second bands from left of IkB-alpha image, top-panel in Fig. 4(A) of Ref.2 is similar to both the fifth and sixth bands from left of pAMPK image in Fig. 1(A) of Ref.2
and the fifth and sixth bands from left of pAMPK image in Fig. 1(a) of Ref.4.
Furthermore, the pAMPK image (all 7 bands) in Fig. 1(A) of Ref.2 is similar to the pAMPK image (all 7 bands) in Fig. 1(a) of Ref.4
,and first to sixth bands from left of the above pAMPK image of Ref.2,9 are similar to the pAMPK image for cilostazol in Fig. 1(D) of Ref.2
and the pAMPK image in Fig. 2(A) of Ref.1
and the pAMPK image for Metformin in Fig. 3(b) of Ref.3.
In addition, the rightside 5 bands (2.5 min – 60 min) of the pAMPK imgae in Fig. 2(A) of Ref.1 are similar to upside-down and left-right reversal of the pAMPK image in Fig. 3(A) of Ref.1.

(2)
The AMPK image in Fig. 1(A) of Ref.2 is similar to the APMK image in Fig. 1(a) of Ref.4.
Moreover, the leftside 6 bands of these two APMK image are similar to the AMPK image in Fig. 2(A) of Ref.1.
Furthermore, rightside 5 bands of this AMPK image in Fig. 2(A) of Ref.1 are similar to the pAMPK image for Milrinone in Fig. 1(D) of Ref.2


(3)
The rightside 5 bands of the AMPK image in Fig. 1(B) of Ref.2 is similar to both the AMPK image in Fig. 2(B) of Ref.1 and the AMPK image in Fig. 1(b) of Ref.4.
Likewise, 5 bands (second to sixth bands from left) of pAMPK image in Fig. 1(B) of Ref.2 are similar to the pAMPK image in Fig. 2(B) of Ref.1 and the pAMPK image in Fig. 1(b) of Ref.4.


(4)
The ACC and pACC images in Fig. 1(A) of Ref.2 are similar to the ACC and pACC images in Fig. 1(a) of Ref.4, respectively.
Moreover, the leftside 6 bands of these two images are similar to the ACC and p-ACC images in Fig. 2(A) of Ref.1.




References

1,
J Atheroscler Thromb. 2010;17(5):503-9.

2,
Cardiovasc Res. 2009 Jan 1;81(1):133-9.

3,
Hypertens Res. 2009 Sep;32(9):765-9.

4.
Am J Hypertens. 2008 Apr;21(4):451-7.





Hypertension Res誌への申立て
件名
Allegations of fabrication and falsification (Hypertension Res 2009 ;32:765-9)
宛先
horiuchi@m.ehime-u.ac.jp
CC
kkario@jichi.ac.jp ; mmogi@m.ehime-u.ac.jp


Please investigate fraudulent data of the article “Telmisartan inhibits cytokine-induced nuclear factor-kappaB activation independently of the peroxisome proliferator-activated receptor-gamma. Nakano A, Hattori Y, Aoki C, Jojima T, Kasai K., published in Hypertens Research. (2009 Sep;32(9):765-9.). You can find fabricated (falsified) Fig. 3(b) : namely,

(1)
The right-side 3 bands (first, second and third bands from right) of IkB-alpha image, top-panel in Fig. 4(A) of Ref.2 are similar to the second, third and fourth bands from left of pAMPK image in Fig. 1(A) of Ref.2.
Moreover, the first and second bands from left of IkB-alpha image, top-panel in Fig. 4(A) of Ref.2 is similar to both the fifth and sixth bands from left of pAMPK image in Fig. 1(A) of Ref.2
and the fifth and sixth bands from left of pAMPK image in Fig. 1(a) of Ref.4.
Furthermore, the pAMPK image (all 7 bands) in Fig. 1(A) of Ref.2 is similar to the pAMPK image (all 7 bands) in Fig. 1(a) of Ref.4
,and first to sixth bands from left of the above pAMPK image of Ref.2,9 are similar to the pAMPK image for cilostazol in Fig. 1(D) of Ref.2
and the pAMPK image in Fig. 2(A) of Ref.1
and the pAMPK image for Metformin in Fig. 3(b) of Ref.3.
In addition, the rightside 5 bands (2.5 min – 60 min) of the pAMPK imgae in Fig. 2(A) of Ref.1 are similar to upside-down and left-right reversal of the pAMPK image in Fig. 3(A) of Ref.1.




References

1,
J Atheroscler Thromb. 2010;17(5):503-9.

2,
Cardiovasc Res. 2009 Jan 1;81(1):133-9.

3,
Hypertens Res. 2009 Sep;32(9):765-9.

4,
Am J Hypertens. 2008 Apr;21(4):451-7.








FEBS Letters誌への申立て
件名
Allegations of fabrication and falsification (FEBS Lett. 2008;582:1719-24)
宛先
febs.letters@bzh.uni-heidelberg.de
CC
felix.wieland@bzh.uni-heidelberg.de ;


Please investigate fraudulent data of the article “High molecular weight adiponectin activates AMPK and suppresses cytokine-induced NF-κB activation in vascular endothelial cells” Hattori Y, Nakano Y, Hattori S, Tomizawa A, Inukai K, Kasai K., published in FEBS Letters. ( 2008 May 28;582(12):1719-24.). You can find fabricated (falsified) Fig. 2(A) : namely,

指摘項目No.19
The left-side 4 bands (first to fourth bands from left) of the AMPK image in Fig. 1(C) of Ref.1 is similar to the left-side 4 bands (first to fourth bands from left) of the AMPK image in Fig. 2(A) of Ref.2.

指摘項目No.20
The left-side 3 bands (first to third bands from left) of pAMPK image in Fig. 1(C) of Ref.1 is similar to the left-side 3 bands (firtst to third bands from left) of pAPMK image in Fig. 2(A) of Ref.2.




References

1,
Cardiovasc Res. 2009 Jan 1;81(1):133-9.

2,
FEBS Lett. 2008 May 28;582(12):1719-24.


Sincerely yours,

Juuichi Jigen
E-mail: 11jigen@mail.goo.ne.jp





Am J Hypertens誌への申立て
件名
Allegations of fabrication and falsification (Am J Hypertens. 2008;21:451-7)
宛先
yvonne.raiford@einstein.yu.edu


Please investigate fraudulent data of the article “Cilostazol activates AMP-activated protein kinase and restores endothelial function in diabetes.” By Suzuki K, Uchida K, Nakanishi N, Hattori Y., published in American Journal of Hypertension (2008 Apr;21(4):451-7.). You can find fabricated (falsified) Fig. 1(a),(b) : namely,

(1)
The first, second and third bands from right of IkB-alpha image, top-panel in Fig. 4(A) of Ref.2 is similar to the second, third and fourth bands from left of pAMPK image in Fig. 1(A) of Ref.2.
Moreover, the first and second bands from left of IkB-alpha image, top-panel in Fig. 4(A) of Ref.2 is similar to both the fifth and sixth bands from left of pAMPK image in Fig. 1(A) of Ref.2
and the fifth and sixth bands from left of pAMPK image in Fig. 1(a) of Ref.4.
Furthermore, the pAMPK image (all 7 bands) in Fig. 1(A) of Ref.2 is similar to the pAMPK image (all 7 bands) in Fig. 1(a) of Ref.4
,and first to sixth bands from left of the above pAMPK image of Ref.2,9 are similar to the pAMPK image for cilostazol in Fig. 1(D) of Ref.2
and the pAMPK image in Fig. 2(A) of Ref.1
and the pAMPK image for Metformin in Fig. 3(b) of Ref.3.
In addition, the rightside 5 bands (2.5 min – 60 min) of the pAMPK imgae in Fig. 2(A) of Ref.1 are similar to upside-down and left-right reversal of the pAMPK image in Fig. 3(A) of Ref.1.

(2)
The AMPK image in Fig. 1(A) of Ref.2 is similar to the APMK image in Fig. 1(a) of Ref.4.
Moreover, the leftside 6 bands of these two APMK image are similar to the AMPK image in Fig. 2(A) of Ref.1.
Furthermore, rightside 5 bands of this AMPK image in Fig. 2(A) of Ref.1 are similar to the pAMPK image for Milrinone in Fig. 1(D) of Ref.2


(3)
The rightside 5 bands of the AMPK image in Fig. 1(B) of Ref.2 is similar to both the AMPK image in Fig. 2(B) of Ref.1 and the AMPK image in Fig. 1(b) of Ref.4.
Likewise, 5 bands (second to sixth bands from left) of pAMPK image in Fig. 1(B) of Ref.2 are similar to the pAMPK image in Fig. 2(B) of Ref.1 and the pAMPK image in Fig. 1(b) of Ref.4.


(4)
The ACC and pACC images in Fig. 1(A) of Ref.2 are similar to the ACC and pACC images in Fig. 1(a) of Ref.4, respectively.
Moreover, the leftside 6 bands of these two images are similar to the ACC and p-ACC images in Fig. 2(A) of Ref.1.




References

1,
J Atheroscler Thromb. 2010;17(5):503-9.

2,
Cardiovasc Res. 2009 Jan 1;81(1):133-9.

3,
Hypertens Res. 2009 Sep;32(9):765-9.

4.
Am J Hypertens. 2008 Apr;21(4):451-7.




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論文捏造についての科学雑誌編集者・出版社への申立て Part.1

2011年01月24日 | 科学雑誌編集者・出版社への申立て
・ 科学雑誌編集者・出版社への申立て
  申立てPart.1,  申立てPart.2,  申立てPart.3,  申立てPart.4
・ 申立てに対する、科学雑誌編集者・出版社からの返信メール
  返信Part.1返信Part.2返信Part.3



Journal of Atherosclerosis and Thrombosis誌への申立て

件名
JAT誌掲載の論文における捏造・改ざんにあたる研究不正行為に関する申立て
送信者
Juuichi Jigen <11jigen@mail.goo.ne.jp>
宛先
jas@kk-kyowa.co.jp
日時
2011年02月02日
_______________________________________

日本動脈硬化学会事務局 御中

Journal of Atherosclerosis and Thrombosis誌に掲載されている下記論文に関して捏造の可能性を確認しました。Figure 2(A)、2(B)、3(A)において、電気泳動画像の流用(捏造、改ざん)が認められます。詳細については、当論文の著者が所属する大学研究機関に送付するために当方が作成した告発文書をご覧下さい。私のホームページ(  http://blog.goo.ne.jp/11jigen_dokkyo_medical_univ_/c/79e83975d9623efb24a6415fe46d4130  )に掲載しています。今後の調査により、捏造などの研究不正行為が行われたと判断された場合、論文撤回の処置をお願いします。

↓ 捏造疑惑が持たれている論文
Anti-Inflammatory Role of Cilostazol in Vascular Smooth Muscle Cells In vitro and In vivo
Journal of Atherosclerosis and Thrombosis
Vol. 17 (2010) , No. 5 503-509
Chie Aoki1), Yoshiyuki Hattori1), Atsuko Tomizawa1), Teruo Jojima1) and Kikuo Kasai1)
1) Department of Endocrinology and Metabolism, Dokkyo University School of Medicine.
http://www.jstage.jst.go.jp/article/jat/17/5/17_503/_article




BBRC誌への申立て


First Name Sender: Juuichi
Last Name Sender: Jigen
Email Address: 11jigen@mail.goo.ne.jp
Subject: Allegation of fabrication and falsification
Journal ID: 622790
Journal Title: Biochemical and Biophysical Research Communications

Text of Email:
Please investigate fraudulent data of the article “Stimulated HSP90 binding to eNOS and activation of the PI3-Akt pathway contribute to globular adiponectin-induced NO production: Vasorelaxation in response to globular adiponectin” by Xi W, Satoh H, Kase H, Suzuki K, Hattori Y., published in
Biochem Biophys Res Common (2005 Jun 24;332(1):200-5.). You can find the falsified (fabricated) Figure 2 : namely, the HSP90 band for gAD(-)/GA(-) is quite similar to that for gAD(+)/GA(+).

References
1,
Biochem Biophys Res Common (2005 Jun 24;332(1):200-5.).
http://www.ncbi.nlm.nih.gov/pubmed/15896318






International Journal of Cardiology誌への申立て


Email Address: 11jigen@mail.goo.ne.jp
Subject: Allegations of fabrication and falsification
Journal ID: 506041
Journal Title: International Journal of Cardiology

Text of Email:

Please investigate fraudulent data of the article "Fluvastatin upregulates endothelial nitric oxide synthase activity via enhancement of its phosphorylation and expression and via an increase in tetrahydrobiopterin in vascular endothelial cells.” by Aoki C, Nakano A, Tanaka S, Yanagi K, Ohta S, Jojima T, Kasai K, Takekawa H, Hirata K, Hattori Y., published in
International Journal of Cardiology (Int J Cardiol. 2010 Nov 17." [Epub ahead of print]). You can find the fabricated (falsified) Figure 1(A) and 1(B) : namely, the p-Ser1177 eNOS (5,15,30,45,60) bands are quite similar to p-Ser633 eNOS (5,15,30,45,60) bands.

Reference
1,
Int J Cardiol. 2010 Nov 17. [Epub ahead of print]
Fluvastatin upregulates endothelial nitric oxide synthase activity via enhancement of its phosphorylation and expression and via an increase in tetrahydrobiopterin in vascular endothelial cells.
http://www.ncbi.nlm.nih.gov/pubmed/21093076







Cardiovasc Res誌への申立て
------------------------------------------------------------
Comments sent via CARDIOVASC RES Feedback Page
------------------------------------------------------------
NAME: Juuichi Jigen
EMAIL: 11jigen@mail.goo.ne.jp

------------------------------------------------------------
COMMENTS:
Please investigate fraudulent data of the article “Statin enhances cytokine-mediated induction of nitric oxide synthesis in vascular smooth muscle cells.” by Hattori Y, Nakanishi N, Kasai K., published in
Cardiovascular Research (2002 Jun;54(3):649-58.). You can find the falsified (fabricated) Figure 6 top panel : namely, the GTPCH band for BASE is quite similar to that for IL-1/IFN, and the GTPCH band for +Ceriva be similar to that for +Fluva.


References
1,
Cardiovascular Research (2002 Jun;54(3):649-58.)
http://cardiovascres.oxfordjournals.org/content/54/3/649.long





J Cardiovasc Pharmacol誌への申立て



From: Juuichi Jigen [mailto:11jigen@mail.goo.ne.jp]
To: Hurd, Emily; Sollenberger, Jennifer; Hee, Laurie
Subject: Allegations of fabrication and falsification

Please investigate fraudulent data of the article "Disruption of the
actin cytoskeleton up-regulates iNOS expression in vascular smooth
muscle cells." by Hattori Y, Kasai K. published in J Cardiovasc
Pharmacol. (2004 Feb;43(2):209-13.). You can find the fabricated
(falsified) Figure 3 : namely, Figure 3 of the above article [J
Cardiovasc Pharmacol. (2004 Feb;43(2):209-13.)] is identical to Figure 5
of another article [Biochim Biophys Acta. (2004 Aug 4;1689(3):267-72.)].


References
1
J Cardiovasc Pharmacol. 2004 Feb;43(2):209-13.
Disruption of the actin cytoskeleton up-regulates iNOS expression in
vascular smooth muscle cells.
Hattori Y, Kasai K.
http://www.ncbi.nlm.nih.gov/pubmed/14716207

2
Biochim Biophys Acta. 2004 Aug 4;1689(3):267-72.
Statin blocks Rho/Rho-kinase signalling and disrupts the actin
cytoskeleton: relationship to enhancement of LPS-mediated nitric oxide
synthesis in vascular smooth muscle cells.
Kato T, Hashikabe H, Iwata C, Akimoto K, Hattori Y.





BBA誌への申立て


Please investigate fraudulent data of the article "Statin blocks Rho/Rho-kinase signalling and disrupts the actin cytoskeleton:
relationship to enhancement of LPS-mediated nitric oxide synthesis in vascular smooth muscle cells”
by Kato T, Hashikabe H, Iwata C, Akimoto K, Hattori Y. published in
Biochim Biophys Acta. (2004 Aug 4;1689(3):267-72. ). You can find the fabricated (falsified) Figure 5 : namely,
Figure 5 of the above article [Biochim Biophys Acta. (2004 Aug 4;1689(3):267-72.)] is identical to
Figure 3 of another article [J Cardiovasc > Pharmacol. (2004 Feb;43(2):209-13.)]


References
1
Biochim Biophys Acta. 2004 Aug 4;1689(3):267-72.
Statin blocks Rho/Rho-kinase signalling and disrupts the actin cytoskeleton:
relationship to enhancement of LPS-mediated nitric > oxide synthesis in vascular smooth muscle cells.
Kato T, Hashikabe H, Iwata C, Akimoto K, Hattori Y.

2
J Cardiovasc Pharmacol. 2004 Feb;43(2):209-13.
Disruption of the actin cytoskeleton up-regulates iNOS expression in vascular smooth muscle cells.
Hattori Y, Kasai K.
http://www.ncbi.nlm.nih.gov/pubmed/14716207






Eur J Pharmacol誌への申立て


First Name Sender: Juuichi
Last Name Sender: Jigen
Email Address: 11jigen@mail.goo.ne.jp
Subject: Allegations of fabrication and falsification
Journal ID: 506087
Journal Title: European Journal of Pharmacology

Text of Email:
Please investigate fraudulent data of the article [Tetrahydrobiopterin prevents endothelial dysfunction and restores adiponectin levels in rats.] by Wang X, Hattori Y, Satoh H, Iwata C, Banba N, Monden T, Uchida K, Kamikawa Y, Kasai K.
published in Eur J Pharmacol [ 2007 Jan 19;555(1):48-53 ]. You can find the fabricated (falsified) Figure 4 : namely, iNOS Western blot image in Figure 4 of the above article [Eur J Pharmacol. 2007 Jan 19;555(1):48-53.] is identical to MCP-1 Western blot image in Figure 3(C) of another article [Life Sci. 2007 Aug 23;81(11):939-43.] and iNOS Protein Western blot images in Figure 5 of another article [J Hypertens. 2005 Jul;23(7):1375-82.].

Moreover, eNOS Western blot image in Figure 4 of the above article [Eur J Pharmacol. 2007 Jan 19;555(1):48-53.] is identical to eNOS Western blot image in Figure 5(a) of another article [J Hypertens. 2005 Jul;23(7):1375-82.] and MCP-1 Wstern blot image (left-right reversal) in Figure 4(B) of another article [Hypertension. 2006 Jun;47(6):1183-8.]



References
1
Eur J Pharmacol. 2007 Jan 19;555(1):48-53. Epub 2006 Oct 18.
Tetrahydrobiopterin prevents endothelial dysfunction and restores adiponectin levels in rats.
Wang X, Hattori Y, Satoh H, Iwata C, Banba N, Monden T, Uchida K, Kamikawa Y, Kasai K.

2
Life Sci. 2007 Aug 23;81(11):939-43. Epub 2007 Aug 17.
Globular adiponectin induces adhesion molecule expression through the sphingosine kinase pathway in vascular endothelial cells.
Kase H, Hattori Y, Jojima T, Okayasu T, Tomizawa A, Suzuki K, Banba N, Monden T, Satoh H, Akimoto K, Kasai K.

3
Hypertension. 2006 Jun;47(6):1183-8. Epub 2006 Apr 24.
Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells.
Hattori Y, Suzuki K, Hattori S, Kasai K.

4
J Hypertens. 2005 Jul;23(7):1375-82.
Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress.
Kase H, Hashikabe Y, Uchida K, Nakanishi N, Hattori Y.
Department of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi, Japan.







Life Sciences誌への申立て

件名
Allegations of fabrication and falsification [Life Sci. 2007 Aug 23;81(11):939-43.]
送信者
Juuichi Jigen <11jigen@mail.goo.ne.jp>
宛先
lifesci@elsevier.com


添付
Life Sci. 2007 81 939-43.pdf (402k)Eur J Pharmacol. 2007 555 48-53..pdf (445k)Hypertension. 2006 47 1183-8..pdf (355k)J Hypertens. 2005 23 1375-82..pdf (4,432k)
Please investigate fraudulent data of the article [Globular adiponectin induces adhesion molecule expression through the sphingosine kinase pathway in vascular endothelial cells.
] byKase H, Hattori Y, Jojima T, Okayasu T, Tomizawa A, Suzuki K, Banba N, Monden T, Satoh H, Akimoto K, Kasai K.
published in Life Sciences (2007 Aug 23;81(11):939-43.). You can find the fabricated (falsified) Figure 3(C) : namely, MCP-1 Western blot image in Figure 3(C) of the above article [Life Sci. 2007 Aug 23;81(11):939-43.] is identical to iNOS Western blot image in Figure 4 of another article [Eur J Pharmacol. 2007 Jan 19;555(1):48-53.] and iNOS Protein Western blot images in Figure 5 of another article [J Hypertens. 2005 Jul;23(7):1375-82.].

Moreover, eNOS Western blot image in Figure 4 of the above article [Eur J Pharmacol. 2007 Jan 19;555(1):48-53.] is identical to eNOS Western blot image in Figure 5(a) of another article [J Hypertens. 2005 Jul;23(7):1375-82.] and MCP-1 Wstern blot image (left-right reversal) in Figure 4(B) of another article [Hypertension. 2006 Jun;47(6):1183-8.]



References
1
Life Sci. 2007 Aug 23;81(11):939-43. Epub 2007 Aug 17.

2
Eur J Pharmacol. 2007 Jan 19;555(1):48-53. Epub 2006 Oct 18.

3
Hypertension. 2006 Jun;47(6):1183-8. Epub 2006 Apr 24.

4
J Hypertens. 2005 Jul;23(7):1375-82.








HYPERTENSION誌への申立て

------------------------------------------------------------
Comments sent via HYPERTENSION Feedback Page
------------------------------------------------------------
NAME: Juuichi Jigen
EMAIL: 11jigen@mail.goo.ne.jp

------------------------------------------------------------
COMMENTS:
Please investigate fraudulent data of the article
[Metformin inhibits cytokine-induced nuclear factor
kappaB activation via AMP-activated protein kinase
activation in vascular endothelial cells.] byHattori Y,
Suzuki K, Hattori S, Kasai K. published in
Hypertension. [ 2006 Jun;47(6):1183-8. ]. You can find
the fabricated (falsified) Figure 4(B) : namely, MCP-1
Wstern blot image in Figure 4(B) of the above article
[Hypertension. 2006 Jun;47(6):1183-8.] is identical to
eNOS Western blot image (left-right reversal) in Figure
4 of another article [Eur J Pharmacol. 2007 Jan
19;555(1):48-53.] eNOS Western blot image (left-right
reversal) in Figure 5(a) of another article [J
Hypertens. 2005 Jul;23(7):1375-82.] and

Moreover, iNOS Western blot image in Figure 4 of the
above article [Eur J Pharmacol. 2007 Jan 19;555(1):48-
53.] is identical to MCP-1 Western blot image in Figure
3(C) of another article [Life Sci. 2007 Aug
23;81(11):939-43.] and iNOS Protein Western blot images
in Figure 5 of another article [J Hypertens. 2005
Jul;23(7):1375-82.].



References
1
Hypertension. 2006 Jun;47(6):1183-8. Epub 2006 Apr 24.

2
Eur J Pharmacol. 2007 Jan 19;555(1):48-53. Epub 2006
Oct 18.

3
Life Sci. 2007 Aug 23;81(11):939-43. Epub 2007 Aug 17.

4
J Hypertens. 2005 Jul;23(7):1375-82.






J Hypertens誌への申立て

件名
Allegations of fabrication and falsification
送信者
Juuichi Jigen <11jigen@mail.goo.ne.jp>
宛先
Phil.Daly@wolterskluwer.com ; Magda.Lewandowska@wolterskluwer.com ; j.hypertension@centroipertensione.191.it ; alberto.zanchetti@unimi.it
CC
translationrights@w

J Hypertens. 2005 23 1375-82..pdf (4,432k)Hypertension. 2006 47 1183-8..pdf (355k)Eur J Pharmacol. 2007 555 48-53..pdf (445k)Life Sci. 2007 81 939-43.pdf (402k)



Please investigate fraudulent data of the article [Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress.
] by Kase H, Hashikabe Y, Uchida K, Nakanishi N, Hattori Y. published in J Hypertens. [2005 Jul;23(7):1375-82.]. You can find the fabricated (falsified) Figure 5(a) : namely, eNOS Western blot image in Figure 5(a) of another article [J Hypertens. 2005 Jul;23(7):1375-82.] is identical to eNOS Western blot image in Figure 4 of another article [Eur J Pharmacol. 2007 Jan 19;555(1):48-53.] and MCP-1 Wstern blot image (left-right reversal) in Figure 4(B) of another article [Hypertension. 2006 Jun;47(6):1183-8.] .

Moreover, iNOS Protein Western blot images in Figure 5 of the above article [J Hypertens. 2005 Jul;23(7):1375-82.] is identical to iNOS Western blot image in Figure 4 of another article [Eur J Pharmacol. 2007 Jan 19;555(1):48-53.] and MCP-1 Western blot image in Figure 3(C) of another article [Life Sci. 2007 Aug 23;81(11):939-43.] and.



References
1
J Hypertens. 2005 Jul;23(7):1375-82.

2
Hypertension. 2006 Jun;47(6):1183-8. Epub 2006 Apr 24.

3
Eur J Pharmacol. 2007 Jan 19;555(1):48-53. Epub 2006 Oct 18.

4
Life Sci. 2007 Aug 23;81(11):939-43. Epub 2007 Aug 17.






Metabolism誌への申立て
件名
Allegations of fabrication and falsification [Metabolism. 2005 Apr;54(4):482-7. ]
送信者
Juuichi Jigen <11jigen@mail.goo.ne.jp>
宛先
cmantzor@bidmc.harvard.edu
添付
Metabolism 2005 54 482-7 Hattori S.pdf (350k)
Diabetologia 2005 48 1066-74 HttoriY.pdf (398k)


Please investigate fraudulent data of the article "Hypoadiponectinemia is caused by chronic blockade of nitric oxide synthesis in rats.” by Hattori S, Hattori Y, Kasai K., published in
Metabolism (2005 Apr;54(4):482-7). You can find the fabricated (falsified) Figure 3(B) and 3(C) : namely,


(1) ・The Northern blot images of Figure 3(B) of [Diabetologia 2005 Jun;48(6):1066-74. ] are similar to those of Figure 2(B) of [Metabolism. 2005 Apr;54(4):482-7. ].
(2) ・The Northern blot images of Figure 3(C) of [Diabetologia 2005 Jun;48(6):1066-74. ] are similar to those of Figure 3(B) and 3(C) of [Metabolism. 2005 Apr;54(4):482-7. ].
(3) ・ The Northern blot images of L-NAME and L-NAME+Pio in Figure 3(B) are identical to those of L-NAME and L-NAME+All in Figure 3(C) [Metabolism. 2005 Apr;54(4):482-7. ].
(4) ・The Northern blot images of AngII and AngII+Tempol in Figure 3(C)’s top panel are identical to those of AngII and AngII+BH4 in Figure 3(C)’s bottom panel [Diabetologia 2005 Jun;48(6):1066-74. ].
(5) ・Three northern blot images of Adiponectin mRNA of Figure 3(B) (Diabetologia 2005 Jun;48(6):1066-74. ) resemble one another closely.



References

1
Metabolism. 2005 Apr;54(4):482-7.
Hypoadiponectinemia is caused by chronic blockade of nitric oxide synthesis in rats.
Hattori S, Hattori Y, Kasai K.
http://www.ncbi.nlm.nih.gov/pubmed/15798955

2
Diabetologia. 2005 Jun;48(6):1066-74. Epub 2005 Apr 30.
Angiotensin-II-induced oxidative stress elicits hypoadiponectinaemia in rats.
Hattori Y, Akimoto K, Gross SS, Hattori S, Kasai K.
http://www.ncbi.nlm.nih.gov/pubmed/15864528





Diabetologia誌への申立て


件名
Allegations of fabrication and falsification [Diabetologia 2005 Jun;48(6):1066-74. ]
送信者
Juuichi Jigen <11jigen@mail.goo.ne.jp>
宛先
diabetologia-j@bristol.ac.uk
添付
Diabetologia 2005 48 1066-74 HttoriY.pdf (398k)
Metabolism 2005 54 482-7 Hattori S.pdf (350k)


Please investigate fraudulent data of the article "Angiotensin-II-induced oxidative stress elicits hypoadiponectinaemia in rats” by Hattori Y, Akimoto K, Gross SS, Hattori S, Kasai K, published in
Diabetologia (2005 Jun;48(6):1066-74. ). You can find the fabricated (falsified) Figure 3(B) and 3(C) : namely,

(1) ・Three northern blot images of Adiponectin mRNA of Figure 3(B) (Diabetologia 2005 Jun;48(6):1066-74. ) resemble one another closely.
(2) ・The Northern blot images of Figure 3(B) of [Diabetologia 2005 Jun;48(6):1066-74. ] are identical to those of Figure 2(B) of [Metabolism. 2005 Apr;54(4):482-7. ].
(3) ・The Northern blot images of Figure 3(C) of [Diabetologia 2005 Jun;48(6):1066-74. ] are identical to those of Figure 3(B) and 3(C) of [Metabolism. 2005 Apr;54(4):482-7. ].
(4) ・The Northern blot images of AngII and AngII+Tempol in Figure 3(C)’s top panel are identical to those of AngII and AngII+BH4 in Figure 3(C)’s bottom panel [Diabetologia 2005 Jun;48(6):1066-74. ].



References

1
Diabetologia. 2005 Jun;48(6):1066-74. Epub 2005 Apr 30.

2
Metabolism. 2005 Apr;54(4):482-7.





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2011年01月24日 | 科学雑誌編集者・出版社への申立て
・ 科学雑誌編集者・出版社への申立て
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Arterioscler Thromb Vasc Biol.誌への申し立て #1
------------------------------------------------------------
Comments sent via AHA JOURNALS Feedback Page
------------------------------------------------------------
NAME: juuichi jigen
EMAIL: 11jigen@mail.goo.ne.jp

------------------------------------------------------------
COMMENTS:
The article “Oral administration of
tetrahydrobiopterin slows the progression of
atherosclerosis in apolipoprotein E-knockout mice” by
Hattori Y, Hattori S, Wang X, Satoh H, Nakanishi N,
Kasai K., published in
Arterioscler Thromb Vasc Biol. (2007 Apr;27(4):865-70)
is for the most part
identical to an article by Suzuki K, Hattori Y, Jojima
T, Tomizawa A, Okayasu T, Kase H, Kawagoe Y, Banba N,
Monden T, Nakanishi N, Kasai K, entitled
“Tetrahydrobiopterin Slows the Progression of
Atherosclerosis” published
in Pteridines (Vol. 18, 2007, pp. 115 - 121). The 2
papers belong to the category of duplicate publication,
therefore, they should be retracted.


References
1,
Arterioscler Thromb Vasc Biol. (2007 Apr;27(4):865-70)
http://atvb.ahajournals.org/cgi/content/full/27/4/865

2.
Pteridines (Vol. 18, 2007, pp. 115 - 121)
http://www.pteridines.sk/bild/2007/109/2007-04-01-
kunihiro.pdf




Arterioscler Thromb Vasc Biol.誌への申し立て #2
------------------------------------------------------------
Comments sent via AHA JOURNALS Feedback Page
------------------------------------------------------------
NAME: juuichi jigen
EMAIL: 11jigen@mail.goo.ne.jp

------------------------------------------------------------
COMMENTS:


The article “HMG-CoA Reductase Inhibitor Increases GTP
Cyclohydrolase I mRNA and Tetrahydrobiopterin in
Vascular Endothelial Cells” by Hattori Y, Nakanishi N,
Akimoto K, Yoshida M, Kasai K., published in
Arterioscler Thromb Vasc Biol. (2003 Feb 1;23(2):176-
82.) is for the most part
identical to an article by Hattori Y, Nakanishi N,
entitled “Statin Increases GTP Cyclohydrolase I mRNA
and 5,6,7,8-Tetrahydrobiopterin
in Vascular Endothelial Cells” published
in Pteridines (Vol. 17, 2006, pp. 65 - 68). The 2
papers belong to the category of duplicate publication,
therefore, they should be retracted.


References
1,
Arterioscler Thromb Vasc Biol. (2003 Feb 1;23(2):176-
82.)
http://atvb.ahajournals.org/cgi/content/full/23/2/176

2.
Pteridines (Vol. 17, 2006, pp. 65 - 68)
http://www.pteridines.sk/bild/2006/85/2006-03-01-
hattori.pdf





CARDIOVASC RES.誌への申し立て #1
------------------------------------------------------------
Comments sent via CARDIOVASC RES Feedback Page
------------------------------------------------------------
NAME: Juuichi Jigen
EMAIL: 11jigen@mail.goo.ne.jp

------------------------------------------------------------
COMMENTS:
The article “Statin enhances cytokine-mediated induction of nitric oxide synthesis in vascular smooth muscle cells.” by Hattori Y, Nakanishi N, Kasai K., published in
Cardiovascular Research (2002 Jun;54(3):649-58.) is for the most part
identical to an article by Hattori Y, Nakanishi N, Suzuki M, Yoshida M, Kasai K, entitled “3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitors Enhance
Cytokine-mediated Induction of Nitric Oxide Synthesis
in Vascular Smooth Muscle Cells” published
in Pteridines (Vol. 13, 2002, pp. 26 - 31.) The 2 papers belong to the category of duplicate publication, therefore, they should be retracted.


References
1,
Cardiovascular Research (2002 Jun;54(3):649-58.)
http://cardiovascres.oxfordjournals.org/content/54/3/649.long

2.
Pteridines (Vol. 13, 2002, pp. 26 - 31.) http://www.pteridines.sk/bild/2002/5/05012002_Yoshiyuki_Hattori.pdf







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